CBD has also been demonstrated to exert a chemopreventive effect in a mouse model of colon cancer.[21] In this experimental system, azoxymethane increased premalignant and malignant lesions in the mouse colon. Animals treated with azoxymethane and CBD concurrently were protected from developing premalignant and malignant lesions. In in vitro experiments involving colorectal cancer cell lines, the investigators found that CBD protected DNA from oxidative damage, increased endocannabinoid levels, and reduced cell proliferation. In a subsequent study, the investigators found that the antiproliferative effect of CBD was counteracted by selective CB1 but not CB2 receptor antagonists, suggesting an involvement of CB1 receptors.[22]


In the U.S., we live in a culture where more is often perceived as being better.  And it’s easy, without even thinking about it, to apply that approach to CBD dosing. But when it comes to CBD, more is not necessarily better. In fact, for many, less CBD is more effective. One way to determine your optimal dosage is to start with a small amount of CBD for a couple weeks and then slowly increase your dosage, carefully taking note of symptoms, until you’re seeing the results you want.

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There’s no definite amount that’s appropriate for everyone, but the ratio of CBD to THC will indicate how psychoactive the product is and if it’s legal in your state. The more CBD compared with THC, the less of a high, and vice versa. “Managing psychoactivity is key to successful cannabis therapy,” says Lee. “Amounts should be made clear on the label and lab-certified so people know what’s helping them and what’s not.”
Another Israeli group postulated that the anti-inflammatory and immunosuppressive effects of CBD might make it a valuable adjunct in the treatment of acute graft-versus-host disease (GVHD) in patients who have undergone allogeneic hematopoietic stem cell transplantation. The authors investigated CBD 300 mg/d in addition to standard GVHD prophylaxis in 48 adult patients who had undergone transplantation predominantly for acute leukemia or myelodysplastic syndrome (NCT01385124 and NCT01596075).[21] The combination of CBD with standard GVHD prophylaxis was found to be safe. Compared with 101 historical controls treated with standard prophylaxis, patients who received CBD appeared to have a lower incidence of grade II to grade IV GVHD, suggesting that a randomized controlled trial (RCT) is warranted.
Some jurisdictions use free voluntary treatment programs and/or mandatory treatment programs for frequent known users. Simple possession can carry long prison terms in some countries, particularly in East Asia, where the sale of cannabis may lead to a sentence of life in prison or even execution. Political parties, non-profit organizations, and causes based on the legalization of medical cannabis and/or legalizing the plant entirely (with some restrictions) have emerged in such countries as China and Thailand.[213][214]

There’s also been a lot of talk lately about “microdosing” CBD. This refers to an incremental process of finding your minimum effective dose. You can do this with any concentration of CBD oil, but lower concentrations will take longer. In a 2017 article in Rolling Stone, Dr. Dustan Sulak outlines his protocol for microdosing. You can begin this process by asking yourself three questions:
A USDA analysis of hemp, “Industrial hemp in the United States: Status and market potential,” was issued in 2000, and is available at www.ers.usda.gov/publications/ages001e/index.htm. This is anonymously-authored, therefore presumably represents a corporate or “official” evaluation. The conclusion was that “US markets for hemp fiber (specialty textiles, paper, and composites) and seed (in food or crushed for oil) are, and will likely remain, small, thin markets. Uncertainty about longrun demand for hemp products and the potential for oversupply discounts the prospects for hemp as an economically viable alternative crop for American farmers.” Noting the oversupply of hempseeds associated with Canada’s 12,000 ha in 1999, the report concluded that the long term demand for hemp products is uncertain, and predicts that the hemp market in the US will likely remain small and limited. With respect to textiles, the report noted the lack of a thriving textile flax (linen) US industry (despite lack of legal barriers), so that it would seem unlikely that hemp could achieve a better market status. With respect to hemp oil, the report noted that hemp oil in food markets is limited by its short shelf life, the fact that it can not be used for frying, and the lack of US Food and Drug Administration approval as GRAS (“generally recognized as safe”). Moreover, summarizing four state analyses of hemp production (McNulty 1995, Ehrensing 1998, Kraenzel et al. 1998, Thompson et al. 1998), profitability seemed doubtful.

Short-term use of the drug impairs thinking and coordination. In long-term studies, teens who smoke marijuana have lower IQs later on, as well as structural differences in their brains, though scientists debate whether this is an effect of the drug or a result of habitual pot smokers seeking out less intellectually stimulating pursuits. A 2016 study on almost 300 students by the University of Montreal published in the journal Development and Psychopathology found that teens who start smoking around age 14 do worse on some cognitive tests by age 20 than non-smokers. They also have a higher school dropout rate. If they wait until age 17 to start, though, the smokers do not seem to have the same impairments, according to the study. 
With your seed or plant acquisition request, you must submit a copy of your industrial hemp growers license, the industrial hemp license for the firm providing the seed and third party test results showing the variety is below the .3%THC threshold. If you want to grow and sell clones, you must provide documentation of permission from the source that allows for replication of those genetics. All seed and clones being brought into the state or leaving the state must be shipped or brought DIRECTLY to the Tennessee Department of agriculture for inventory. Movement permits are required to track the purchase or movement of industrial hemp seed, seedling and clones (viable material).
The pulp and paper industry based on wood has considered the use of hemp for pulp, but only on an experimental basis. Hemp’s long fibers could make paper more recyclable. Since virgin pulp is required for added strength in the recycling of paper, hemp pulp would allow for at least twice as many cycles as wood pulp. However, various analyses have concluded that the use of hemp for conventional paper pulp is not profitable (Fertig 1996).

Medical marijuana can soothe nausea and increase appetite, quiet pain, soothe anxiety and even reduce epileptic seizures. Other research on the healing effects of cannabis is being examined. For example, research suggests that THC may be able to improve memory according to a 2016 study on mice. More than half of the United States has legalized marijuana for medical use.
Last year, the Hemp Industries Association (HIA) estimated the total retail value of all hemp products sold in the U.S. at $620 million. Sadly, all of the raw hemp materials were imported from other countries. (More on that later.) Hemp is an attractive rotation crop for farmers. As it grows, hemp breathes in CO2, detoxifies the soil, and prevents soil erosion. What’s left after harvest breaks down into the soil, providing valuable nutrients.

In the meantime, some physicians are forging ahead — and cashing in. Joe Cohen is a doctor at Holos Health, a medical marijuana clinic in Boulder. I asked him what CBD is good for, and he read me a long list of conditions: pain, inflammation, nausea, vomiting, intestinal cramping, anxiety, psychosis, muscle spasms, hyperactive immune systems, nervous system degeneration, elevated blood sugar and more. He also claimed that CBD has anti-cancer properties and can regenerate brain cells and reduce the brain’s levels of amyloid beta — a kind of protein that’s been linked to Alzheimer’s disease. I asked for references, noting that most of these weren’t listed in the Academies report or a similar review published in the Journal of the American Medical Association. “I think you just have to Google search it,” he said. It’s true that a preliminary study found hints that cannabinoids might reduce beta amyloid proteins in human brain cells, but the study was done in cells grown in a lab, not in people. As for cancer, the FDA sent warning letters last year to four companies that were selling products that claimed to “prevent, diagnose, treat or cure” cancer.
I discovered in my research that hemp is really legal in all 50 states so I guess this must be a very complicated thing. It may be likely some states are allowed to grow it and others aren’t, I don’t know but all I know is somewhere in my research it said it was legal in all 50 states. Anyway, I got my oil on auto delivery, I really need to start using it in my food a little more often to help with certain health issues including but not limited to arthritis pain 😇👍
An observational study assessed the effectiveness of nabilone in advanced cancer patients who were experiencing pain and other symptoms (anorexia, depression, and anxiety). The researchers reported that patients who used nabilone experienced improved management of pain, nausea, anxiety, and distress when compared with untreated patients. Nabilone was also associated with a decreased use of opioids, nonsteroidal anti-inflammatory drugs, tricyclic antidepressants, gabapentin, dexamethasone, metoclopramide, and ondansetron.[56]
Some users may experience an episode of acute psychosis, which usually abates after six hours, but in rare instances, heavy users may find the symptoms continuing for many days.[52] A reduced quality of life is associated with heavy cannabis use, although the relationship is inconsistent and weaker than for tobacco and other substances.[53] It is unclear, however, if the relationship is cause and effect.[53]
Over the past two years, 17 states have passed laws legalizing CBD so that patients can obtain the drug without fear of prosecution from local authorities. For intractable childhood epilepsies—the sorts of seizure disorders that for centuries have ruined lives and shattered families, the ones even specialists like Hernandez dread—CBD could be a miracle cure.
Pinfold Consulting. 1998. (G. Pinfold Consulting Economists Ltd. and J. White, InfoResults Ltd.). A maritime industrial hemp product marketing study. Prepared for Nova Scotia Agriculture and Marketing (Marketing and Food Industry Development), and New Brunswick Agriculture & Rural Development (Marketing and Business Development). agri.gov.ns.ca/pt/agron/hemp/hempms.htm
Another Israeli group postulated that the anti-inflammatory and immunosuppressive effects of CBD might make it a valuable adjunct in the treatment of acute graft-versus-host disease (GVHD) in patients who have undergone allogeneic hematopoietic stem cell transplantation. The authors investigated CBD 300 mg/d in addition to standard GVHD prophylaxis in 48 adult patients who had undergone transplantation predominantly for acute leukemia or myelodysplastic syndrome (NCT01385124 and NCT01596075).[21] The combination of CBD with standard GVHD prophylaxis was found to be safe. Compared with 101 historical controls treated with standard prophylaxis, patients who received CBD appeared to have a lower incidence of grade II to grade IV GVHD, suggesting that a randomized controlled trial (RCT) is warranted.
On Oct. 22 and 23, KDA participated in four informational meetings about Industrial Hemp in Manhattan, Salina, Colby and Garden City hosted by Kansas Farmers Union. The presentation shared by KDA at those meetings can be seen here: KDA Industrial Hemp Presentation. Information on the event, including the video of the guest presenter, can be found on the Kansas Farmers Union website. 
Some users may experience an episode of acute psychosis, which usually abates after six hours, but in rare instances, heavy users may find the symptoms continuing for many days.[52] A reduced quality of life is associated with heavy cannabis use, although the relationship is inconsistent and weaker than for tobacco and other substances.[53] It is unclear, however, if the relationship is cause and effect.[53]
Tammy et al, Through trial and error you will find a correct dosage. Try 50 mg daily....25 each 2x daily....if no results up the dosage until it works for you. Remember, there has never been a death from marijuana or CBD use. You might want to try a tincture or rub with CBD and THC. You won't get the psych high from it. Helps my friend with PArkinsons tremors. She takes 50mg of tincture and uses the rub morning and night. It is a miracle for arthritis. Good luck
Selection for fiber has resulted in strains that have much more bark fiber tissues and much less woody core than encountered in narcotic strains, oilseed strains, and wild plants (Fig. 12). In non-fiber strains of Cannabis, bark can be less than one quarter of the stem tissues (i.e. more than three quarters can be woody core). By contrast, in fiber strains half of the stem tissues can be bark, and more than half of this can be the desirable long primary fibers (de Meijer 1995). Non-fiber strains rarely have as much as 15% fiber in the bark.

The first example of the use of hempcrete was in 1986 in France with the renovation of the Maison de la Turquie in Nogent-sur-Seine by the innovator Charles Rasetti.[27] In the UK hemp lime was first used in 2000 for the construction of two test dwellings in Haverhill.[28] Designed by Modece Architects,[29] who pioneered hemp's use in UK construction, the hemp houses were monitored in comparison with other standard dwellings by BRE. Completed in 2009, the Renewable House is one of the most technologically advanced made from hemp-based materials.[30] The first US home made of hemp-based materials was completed in August 2010 in Asheville, North Carolina.[31]
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