An absence of such fiber-strain traits as tallness, limited branching, long internodes, and very hollow stems, is characteristic of narcotic strains. Drug forms have historically been grown in areas south of the north-temperate zone, often close to the equator, and are photoperiodically adapted to a long season. When grown in north-temperate climates maturation is much-delayed until late fall, or the plants succumb to cold weather before they are able to produce seeds. Unlike fiber strains that have been selected to grow well at extremely high densities, drug strains tend to be less persistent when grown in high concentration (de Meijer 1994). Drug strains can be very similar in appearance to fiber strains. However, a characteristic type of narcotic plant was selected in southern Asia, particularly in India and neighboring countries. This is dioecious, short (about a meter in height), highly branched, with large leaves (i.e. wide leaflets), and it is slow to mature. The appearance is rather like a short, conical Christmas tree.
About half of the world market for hemp oil is currently used for food and food supplements (de Guzman 2001). For edible purposes, hempseed oil is extracted by cold pressing. Quality is improved by using only the first pressing, and minimizing the number of green seeds present. The oil varies in color from off-yellow to dark green. The taste is pleasantly nutty, sometimes with a touch of bitterness. Hemp oil is high in unsaturated fatty acids (of the order of 75%), which can easily oxidize, so it is unsuitable for frying or baking. The high degree of unsaturation is responsible for the extreme sensitivity to oxidative rancidity. The oil has a relatively short shelf life. It should be extracted under nitrogen (to prevent oxidation), protected from light by being kept in dark bottles, and from heat by refrigeration. Addition of anti-oxidants prolongs the longevity of the oil. Steam sterilization of the seeds, often required by law, allows air to penetrate and so stimulates rancidity. Accordingly, sterilized or roasted hemp seeds, and products made from hemp seed that have been subjected to cooking, should be fresh. The value of hemp oil from the point of view of the primary components is discussed below. In addition, it has been suggested that other components, including trace amounts of terpenes and cannabinoids, could have health benefits (Leizer et al. 2000). According to an ancient legend (Abel 1980), Buddha, the founder of Buddhism, survived a 6-year interval of asceticism by eating nothing but one hemp seed daily. This apocryphal story holds a germ of truth—hemp seed is astonishingly nutritional.
All this means that scientists can still only obtain marijuana-derived CBD from farms licensed by the National Institute on Drug Abuse (which until this year meant only one farm owned by the University of Mississippi). As for whether you should have a preference for CBD that comes from hemp, marijuana, or a pure synthetically produced version, there are some theories that THC—and even the smell and taste of cannabis—might make CBD more effective, but Bonn-Miller says these ideas have yet to be proven.
In the past few years, just such a cure has seemingly presented itself. Amid the less common remedies that can be found on the internet—special diets, meditation, biofeedback, surgical implants—a new product has recently gained prominence: CBD oil (sometimes known simply as “hemp oil”), so named for its chief chemical compound, cannabidiol, which occurs naturally in cannabis plants. In online forums and news articles, CBD has been hailed as a new frontier in epilepsy treatment, with parents testifying that it managed to stop their children’s seizures when nothing else could.
Cultivated industrial hemp plants usually consist of a spindly main stalk covered with leaves. Considered a low-maintenance crop, hemp plants typically reach between 6 to 15 feet in height. Depending on the purpose, variety and climatic conditions, the period between planting and harvesting ranges from 70 to 140 days. One acre of hemp can yield an average of 700 pounds of grain, which in turn can be pressed into about 22 gallons of oil and 530 pounds of meal. The same acre will also produce an average of 5,300 pounds of straw, which can be transformed into approximately 1,300 pounds of fiber.
CBD’s potential usefulness in treating certain conditions is yet another argument in favor of legalizing the entire cannabis plant. Removing cannabis from the federal list of Schedule I narcotics that are illegal under the Controlled Substances Act would allow scientists to research its full medical potential and pharmaceutical companies in the United States to develop marijuana-based drugs and submit them for FDA approval. Government-regulated labs could test products like CBD oil to ensure safety and quality. Doctors could prescribe marijuana- based medicines with full knowledge of potential side effects and drug interactions, and without fear of losing their medical licenses or being thrown in jail.
Given the uncertainties and handicaps associated with hemp, it is fortunate that there are compensating factors. As noted, as a crop hemp offers some real environmental advantages, particularly with regard to the limited needs for herbicides and pesticides. Hemp is therefore pre-adapted to organic agriculture, and accordingly to the growing market for products associated with environmentally-friendly, sustainable production. Hemp products are an advertiser’s dream, lending themselves to hyperbole (“healthiest salad oil in the world,” “toughest jeans on the market”). While the narcotics image of C. sativa is often disadvantageous, advertisers who choose to play up this association do so knowing that it will attract a segment of the consuming population. In general, the novelty of hemp means that many consumers are willing to pay a premium price. It might also be said that those who have entered the hemp industry have tended to be very highly motivated, resourceful, and industrious, qualities that have been needed in the face of rather formidable obstacles to progress.
Not until the end of the 20th century was the specific mechanism of action of THC at the neuronal level studied.[citation needed] Researchers have subsequently confirmed that THC exerts its most prominent effects via its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor, both of which are G protein-coupled receptors.[133] The CB1 receptor is found primarily in the brain as well as in some peripheral tissues, and the CB2 receptor is found primarily in peripheral tissues, but is also expressed in neuroglial cells.[134] THC appears to alter mood and cognition through its agonist actions on the CB1 receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose-dependent manner. These actions can be blocked by the selective CB1 receptor antagonist rimonabant (SR141716), which has been shown in clinical trials to be an effective treatment for smoking cessation, weight loss, and as a means of controlling or reducing metabolic syndrome risk factors.[135] However, due to the dysphoric effect of CB1 receptor antagonists, this drug is often discontinued due to these side effects.[136]
The exploding recreational market for marijuana has rapidly popularized many methods of consuming cannabis that was decidedly part of the fringe just a few short years ago. Smoking marijuana remains the most widely embraced method, due to the greater accessibility of marijuana flower. But legal recreational cannabis is introducing many marijuana users to new forms of the drug, especially concentrates and edibles. Here’s a brief overview of the major methods for consuming marijuana.
And without high-quality trials, experts don’t know how much is best for a given purpose. The staff at Roth’s dispensary told her, “Try some once or twice a day and see what happens.” (Half a dropper’s worth was a good amount for her.) One thing scientists feel confident about is that CBD is not dangerous. It won’t damage vital organs even at doses as high as 5,000 mg a day, Marcu says, and nobody has died from simply overdosing on a cannabis product.
^ Jump up to: a b Batalla A, Bhattacharyya S, Yücel M, Fusar-Poli P, Crippa JA, Nogué S, Torrens M, Pujol J, Farré M, Martin-Santos R (2013). "Structural and functional imaging studies in chronic cannabis users: a systematic review of adolescent and adult findings". PLOS One. 8 (2): e55821. doi:10.1371/journal.pone.0055821. PMC 3563634. PMID 23390554. The most consistently reported brain alteration was reduced hippocampal volume which was shown to persist even after several months of abstinence in one study and also to be related to the amount of cannabis use Other frequently reported morphological brain alterations related to chronic cannabis use were reported in the amygdala the cerebellum and the frontal cortex...These findings may be interpreted as reflecting neuroadaptation, perhaps indicating the recruitment of additional regions as a compensatory mechanism to maintain normal cognitive performance in response to chronic cannabis exposure, particularly within the prefrontal cortex area.

An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic mammary cells.[18] Other studies have also shown the antitumor effect of cannabinoids (i.e., CBD and THC) in preclinical models of breast cancer.[19,20]

Hernandez said interactions between FDA-approved pharmaceuticals and CBD oils are a serious concern. “What we’ve found so far is that [CBD] can actually affect the levels of some of your epilepsy medications,” Hernandez told me. The diarrhea and vomiting associated with CBD oil ingestion can lower the levels of other drugs in patients’ bloodstreams, while the way the body absorbs CBD can raise the levels of certain medications.
On October 17, 2018, Canada legalized cannabis for recreational adult use[54] making it the second country in the world to do so after Uruguay and the first G7 nation.[55] The Canadian Licensed Producer system may become the Gold Standard in the world for safe and secure cannabis production,[56] including provisions for a robust craft cannabis industry where many expect opportunities for experimenting with different strains.[57] Laws around use vary from province to province including age limits, retail structure, and growing at home.[58]
It’s easy to see why vaping has become such a popular method for consuming marijuana. The method is remarkably discrete and produces none of the telltale “weed smells” that often betray cannabis users. Vape pens and other hand-held devices are portable and convenient. They’re free of many of the harsh marijuana plant compounds that can harm your lung health, like tars. And companies are getting better at crafting high-quality, flavorful vape cartridges with a wide array of cannabinoid profiles.
Not until the end of the 20th century was the specific mechanism of action of THC at the neuronal level studied.[citation needed] Researchers have subsequently confirmed that THC exerts its most prominent effects via its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor, both of which are G protein-coupled receptors.[133] The CB1 receptor is found primarily in the brain as well as in some peripheral tissues, and the CB2 receptor is found primarily in peripheral tissues, but is also expressed in neuroglial cells.[134] THC appears to alter mood and cognition through its agonist actions on the CB1 receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose-dependent manner. These actions can be blocked by the selective CB1 receptor antagonist rimonabant (SR141716), which has been shown in clinical trials to be an effective treatment for smoking cessation, weight loss, and as a means of controlling or reducing metabolic syndrome risk factors.[135] However, due to the dysphoric effect of CB1 receptor antagonists, this drug is often discontinued due to these side effects.[136]
There are ways to strain dangerous contaminants out of raw hemp paste. And most companies stand behind their quality and safety procedures. “We continuously test all our products ... to ensure our consumers get the levels of natural constituents they expect from the quality hemp stalk oil they purchase,” HempMedsPx states on its web site. “Additionally, all our products are tested for safety, to ensure there are no solvents, heavy metals, or other potentially harmful materials in our oil. Because we take these steps, we are always confident in our products, and you can be too.”

My mother has dementia/Alzheimers along with a broken knee that they will not repair do to her mental status. She is currently in a nursing home. I firmly believe her mental situation began with the over use of hydrocodone for over 30 years and was acerbated by the trauma of breaking and disconnecting her knee cap. Since weaning her off of her meds (still in progress) we have regained much of her consciousness. I want to try CBD to help in her recovery or to help slow down the disease. I cannot find a dosage recommendation plus the nursing home/doctor does not recommend it. I would need to give it to her when I am there visiting (about 3 - 4 times per week). Is there a recommended dosage for dementia/Alzheimers?
It has been contended that hemp is notably superior to most crops in terms of biomass production, but van der Werf (1994b) noted that the annual dry matter yield of hemp (rarely approaching 20 t/ha) is not exceptional compared to maize, beet, or potato. Nevertheless, hemp has been rated on a variety of criteria as one of the best crops available to produce energy in Europe (Biewinga and van der Bijl 1996). Hemp, especially the hurds, can be burned as is or processed into charcoal, methanol, methane, or gasoline through pyrolysis (destructive distillation). As with maize, hemp can also be used to create ethanol. However, hemp for such biomass purposes is a doubtful venture in North America. Conversion of hemp biomass into fuel or alcohol is impractical on this continent, where there are abundant supplies of wood, and energy can be produced relatively cheaply from a variety of sources. Mallik et al. (1990) studied the possibility of using hemp for “biogas” (i.e. methane) production, and concluded that it was unsuitable for this purpose. Pinfold Consulting (1998) concluded that while there may be some potential for hemp biomass fuel near areas where hemp is cultivated, “a fuel ethanol industry is not expected to develop based on hemp.”
Support for legalization has steadily grown over the last several years. Today, medical marijuana is legal in 23 states and the District of Columbia. And even federal officials have begun to soften their stances. Last fall, outgoing Attorney General Eric Holder signaled his support for removing marijuana from the list of Schedule I narcotics. “I think it’s certainly a question we need to ask ourselves, whether or not marijuana is as serious of a drug as heroin,” Holder said. This summer, Chuck Rosenberg, the acting administrator of the U.S. Drug Enforcement Administration, acknowledged that marijuana is not as dangerous as other Schedule I drugs and announced his agents would not be prioritizing marijuana enforcement. Still, as long as marijuana remains illegal under federal law, the haphazard system in which it is studied, produced, and distributed will remain, and Americans will not be able to take full advantage of its medicinal properties.

In 1976, Canadian botanist Ernest Small[65] and American taxonomist Arthur Cronquist published a taxonomic revision that recognizes a single species of Cannabis with two subspecies: C. sativa L. subsp. sativa, and C. sativa L. subsp. indica (Lam.) Small & Cronq.[61] The authors hypothesized that the two subspecies diverged primarily as a result of human selection; C. sativa subsp. sativa was presumably selected for traits that enhance fiber or seed production, whereas C. sativa subsp. indica was primarily selected for drug production. Within these two subspecies, Small and Cronquist described C. sativa L. subsp. sativa var. spontanea Vav. as a wild or escaped variety of low-intoxicant Cannabis, and C. sativa subsp. indica var. kafiristanica (Vav.) Small & Cronq. as a wild or escaped variety of the high-intoxicant type. This classification was based on several factors including interfertility, chromosome uniformity, chemotype, and numerical analysis of phenotypic characters.[51][61][66]
Cannabis, especially the cannabinoid CBD, has also demonstrated its abilities as a powerful anti-convulsant. This property is what accounts for cannabis’ ability to reduce the severity and frequency of seizures, especially for people with epilepsy. In the United States, epilepsy is the most widely adopted qualifying condition for medical cannabis use, especially for children.

Over the past two years, 17 states have passed laws legalizing CBD so that patients can obtain the drug without fear of prosecution from local authorities. For intractable childhood epilepsies—the sorts of seizure disorders that for centuries have ruined lives and shattered families, the ones even specialists like Hernandez dread—CBD could be a miracle cure.
Cannabis is by far the most widely cultivated, trafficked and abused illicit drug. Half of all drug seizures worldwide are cannabis seizures. The geographical spread of those seizures is also global, covering practically every country of the world. About 147 million people, 2.5% of the world population, consume cannabis (annual prevalence) compared with 0.2% consuming cocaine and 0.2% consuming opiates. In the present decade, cannabis abuse has grown more rapidly than cocaine and opiate abuse. The most rapid growth in cannabis abuse since the 1960s has been in developed countries in North America, Western Europe and Australia. Cannabis has become more closely linked to youth culture and the age of initiation is usually lower than for other drugs. An analysis of cannabis markets shows that low prices coincide with high levels of abuse, and vice versa. Cannabis appears to be price-inelastic in the short term, but fairly elastic over the longer term. Though the number of cannabis consumers is greater than opiate and cocaine consumers, the lower prices of cannabis mean that, in economic terms, the cannabis market is much smaller than the opiate or cocaine market.

"The dairy industry is really in trouble, and so, one of the things that I find really important is finding value-added products," Gilbert Jenkins said. "I am not an et. al scientist, I am not a dairy farmer, but I know about the crops that they grow. Having an opportunity to grow a crop -- even on just a portion of the acres -- that could bring in new income."
Cannabis , also known as marijuana, originated in Central Asia but is grown worldwide today. In the United States, it is a controlled substance and is classified as a Schedule I agent (a drug with a high potential for abuse, and no currently accepted medical use). The Cannabis plant produces a resin containing psychoactive compounds called cannabinoids, in addition to other compounds found in plants, such as terpenes and flavonoids. The highest concentration of cannabinoids is found in the female flowers of the plant.[1] Clinical trials conducted on medicinal Cannabis are limited. The U.S. Food and Drug Administration (FDA) has not approved the use of Cannabis as a treatment for any medical condition. To conduct clinical drug research with Cannabis in the United States, researchers must file an Investigational New Drug (IND) application with the FDA, obtain a Schedule I license from the U.S. Drug Enforcement Administration, and obtain approval from the National Institute on Drug Abuse.
Perhaps the most important difference between hemp and marijuana is that marijuana – no pun intended – has a high delta-9 tetrahydrocannabinol content, or THC, which supplies the sought-after psychotropic effect, but it’s low in cannabidiol content, or CBD, which has medicinal properties. Hemp is just the opposite, being typically high in CBD and low in THC, meaning it’s not going to get anybody stoned. In fact, clinical studies show that CBD blocks the effect of THC in the nervous system. Both THC and CBD contain cannabinoid, but it’s the amount that needs to examined, because CBD is currently a Schedule 1 controlled substance. That means that at present, there’s currently no permissible medical protocol in the US.

Karl W. Hillig, a graduate student in the laboratory of long-time Cannabis researcher Paul G. Mahlberg[77] at Indiana University, conducted a systematic investigation of genetic, morphological, and chemotaxonomic variation among 157 Cannabis accessions of known geographic origin, including fiber, drug, and feral populations. In 2004, Hillig and Mahlberg published a chemotaxonomic analysis of cannabinoid variation in their Cannabis germplasm collection. They used gas chromatography to determine cannabinoid content and to infer allele frequencies of the gene that controls CBD and THC production within the studied populations, and concluded that the patterns of cannabinoid variation support recognition of C. sativa and C. indica as separate species, but not C. ruderalis.[52] The authors assigned fiber/seed landraces and feral populations from Europe, Central Asia, and Turkey to C. sativa. Narrow-leaflet and wide-leaflet drug accessions, southern and eastern Asian hemp accessions, and feral Himalayan populations were assigned to C. indica. In 2005, Hillig published a genetic analysis of the same set of accessions (this paper was the first in the series, but was delayed in publication), and proposed a three-species classification, recognizing C. sativa, C. indica, and (tentatively) C. ruderalis.[55] In his doctoral dissertation published the same year, Hillig stated that principal components analysis of phenotypic (morphological) traits failed to differentiate the putative species, but that canonical variates analysis resulted in a high degree of discrimination of the putative species and infraspecific taxa.[78] Another paper in the series on chemotaxonomic variation in the terpenoid content of the essential oil of Cannabis revealed that several wide-leaflet drug strains in the collection had relatively high levels of certain sesquiterpene alcohols, including guaiol and isomers of eudesmol, that set them apart from the other putative taxa.[79] Hillig concluded that the patterns of genetic, morphological, and chemotaxonomic variation support recognition of C. sativa and C. indica as separate species. He also concluded there is little support to treat C. ruderalis as a separate species from C. sativa at this time, but more research on wild and weedy populations is needed because they were underrepresented in their collection.
In the United States, the legality of medical marijuana varies in substantial ways from state to state. There are currently 29 US states with legal medical cannabis laws, as well as the District of Columbia. That leaves 21 states where medical marijuana is entirely prohibited. Marijuana cultivation, possession, and use in any form is illegal at the federal level.
An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic mammary cells.[18] Other studies have also shown the antitumor effect of cannabinoids (i.e., CBD and THC) in preclinical models of breast cancer.[19,20]

Also high in fiber, hemp seeds are more digestible than any other high-protein food, including meat, cheese, eggs, human milk, or cows’ milk. They’re high in antioxidants, and minerals like iron, zinc and copper as well as calcium, magnesium, potassium, carotene, thiamin (vitamin B1), riboflavin (vitamin B2), vitamin B6 and vitamin E. If that’s not enough, there’s also chlorophyll, sulfur, phosphorus, phospholipids, and phytosterols.


CBD has been producing a whole lot of buzz in the health community of late – but perhaps not the kind of buzz you might expect from a cannabinoid. Since you’re reading this, you’ve probably heard of CBD and its many touted benefits. From chronic pain to mental health, CBD has the potential to alleviate an astonishing number of ailments. But like many, you might be fuzzy on the details. Consider this your primer on all things CBD.
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Concerned about Mykayla’s stomach cramps, Krenzler, who lives in Portland, Oregon, sent a sample of the oil off to Going Green Labs in Albany, Oregon. Like most labs catering to the cannabis industry, Going Green mainly performs THC potency tests. According to Krenzler, when the lab tested his sample, it found that the Real Scientific Hemp Oil contained much more THC than HempMedsPx had claimed—3.8 percent, instead of roughly 1 percent. Krenzler said he was “disturbed” by the finding, and also by the implications it had for other parents of sick children. Medical marijuana is legal in Oregon, but Krenzler noted that in other states that have not legalized pot, anyone purchasing a product with more than a trace amount of THC could find themselves in legal jeopardy. “I feel that HempMeds had misrepresented their product,” Krenzler said.
The first example of the use of hempcrete was in 1986 in France with the renovation of the Maison de la Turquie in Nogent-sur-Seine by the innovator Charles Rasetti.[27] In the UK hemp lime was first used in 2000 for the construction of two test dwellings in Haverhill.[28] Designed by Modece Architects,[29] who pioneered hemp's use in UK construction, the hemp houses were monitored in comparison with other standard dwellings by BRE. Completed in 2009, the Renewable House is one of the most technologically advanced made from hemp-based materials.[30] The first US home made of hemp-based materials was completed in August 2010 in Asheville, North Carolina.[31]
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