The United Kingdom and Germany resumed commercial production in the 1990s. British production is mostly used as bedding for horses; other uses are under development. Companies in Canada, the UK, the United States, and Germany, among many others, process hemp seed into a growing range of food products and cosmetics; many traditional growing countries still continue to produce textile-grade fibre.
State legislatures have taken action to promote industrial hemp as an agricultural commodity in recent years. A wide range of products, including fibers, textiles, paper, construction and insulation materials, cosmetic products, animal feed, food, and beverages all may use hemp. The plant is estimated to be used in more than 25,000 products spanning nine markets: agriculture, textiles, recycling, automotive, furniture, food/nutrition/beverages, paper, construction materials and personal care.
Cannabis is mostly used for recreation or as a medicinal drug, although it may also be used for spiritual purposes. In 2013, between 128 and 232 million people used cannabis (2.7% to 4.9% of the global population between the ages of 15 and 65). It is the most commonly used illegal drug both in the world and the United States. The countries with the highest use among adults as of 2018 are Zambia, the United States, Canada, and Nigeria. In 2016, 51% of people in the United States had ever used cannabis. About 12% had used it in the past year, and 7.3% had used it in the past month.
That leaves those touting CBD’s effectiveness pointing primarily to research in mice and petri dishes. There, CBD (sometimes combined with small amounts of THC) has shown promise for helping pain, neurological conditions like anxiety and PTSD, and the immune system—and therefore potentially arthritis, diabetes, multiple sclerosis, cancer, and more.
Cannabis use generally makes psychotic symptoms worse and lowers the person’s chances of recovery from a psychotic episode. People with a psychotic illness who use drugs experience more delusions, hallucinations and other symptoms. They have a higher rate of hospitalisation for psychosis, and treatment is generally less effective for them. People with a psychotic illness should not use cannabis.
For centuries, industrial hemp (plant species Cannabis sativa) has been a source of fiber and oilseed used worldwide to produce a variety of industrial and consumer products. Currently, more than 30 nations grow industrial hemp as an agricultural commodity, which is sold on the world market. In the United States, however, production is strictly controlled under existing drug enforcement laws. Currently there is no large-scale commercial production in the United States and the U.S. market depends on imports.
One of the most curious uses of hemp is as a fence to prevent pollen transfer in commercial production of seeds. Isolation distances for ensuring that seeds produced are pure are considerable for many plants, and often impractical. At one point in the 1980s, the only permitted use of hemp in Germany was as a fence or hedge to prevent plots of beets being used for seed production from being contaminated by pollen from ruderal beets. The high and rather inpenetrable hedge that hemp can produce was considered unsurpassed by any other species for the purpose. As well, the sticky leaves of hemp were thought to trap pollen. However, Saeglitz et al. (2000) demonstrated that the spread of beet pollen is not effectively prevented by hemp hedges. Fiber (i.e. tall) cultivars of hemp were also once used in Europe as wind-breaks, protecting vulnerable crops against wind damage. Although hemp plants can lodge, on the whole very tall hemp is remarkably resistant against wind.
In the UK, the Department for Environment, Food and Rural Affairs treats hemp as a purely non-food crop, but with proper licensing and proof of less than 0.2% THC concentration, hemp seeds can be imported for sowing or for sale as a food or food ingredient. In the U.S., imported hemp can be used legally in food products and, as of 2000, was typically sold in health food stores or through mail order.
Epidiolex is the first FDA-approved treatment in the U.S. that contains a purified drug substance derived from marijuana -- CBD -- and the first treatment for Dravet syndrome. In September 2018 the FDA rescheduled cannabidiol from a C-I controlled substance to a C-V controlled substance, meaning it has a proven medical use but a low risk of abuse. This change allows Epidiolex to be marketed in the U.S.
An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic mammary cells. Other studies have also shown the antitumor effect of cannabinoids (i.e., CBD and THC) in preclinical models of breast cancer.[19,20]
Finding cultivars suited to local conditions is a key to success. Hemp prefers warm growing conditions, and the best European fiber strains are photoperiodically adapted to flowering in southern Europe, which provides seasons of at least 4 months for fiber, and 5.5 months for seed production. Asian land races are similarly adapted to long seasons. In Canada, many of the available cultivars flower too late in the season for fiber production, and the same may be predicted for the northern US. Fiber production should also be governed by availability of moisture throughout the season, and the need for high humidity in the late summer and fall for retting, so that large areas of the interior and west of North America are not adapted to growing fiber hemp. The US Corn Belt has traditionally been considered to be best for fiber hemp. There are very few cultivars dedicated to oilseed production (such as ‘Finola’ and ‘Anka’) or that at least are known to produce good oilseed crops (such as ‘Fasamo’ and ‘Uniko-B’). Oilseed production was a specialty of the USSR, and there is some likelihood that northern regions of North America may find short-season, short-stature oilseed cultivars ideal.
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Cannabis is believed to be an aggravating factor in rare cases of arteritis, a serious condition that in some cases leads to amputation. Because 97% of case-reports also smoked tobacco, a formal association with cannabis could not be made. If cannabis arteritis turns out to be a distinct clinical entity, it might be the consequence of vasoconstrictor activity observed from delta-8-THC and delta-9-THC. Other serious cardiovascular events including myocardial infarction, stroke, sudden cardiac death, and cardiomyopathy have been reported to be temporally associated with cannabis use. Research in these events is complicated because cannabis is often used in conjunction with tobacco, and drugs such as alcohol and cocaine. These putative effects can be taken in context of a wide range of cardiovascular phenomena regulated by the endocannabinoid system and an overall role of cannabis in causing decreased peripheral resistance and increased cardiac output, which potentially could pose a threat to those with cardiovascular disease. There is some evidence from case reports that cannabis use may provoke fatal cardiovascular events in young people who have not been diagnosed with cardiovascular disease. Smoking cannabis has also been shown to increase the risk of myocardial infarction by 4.8 times for the 60 minutes after consumption.
It sounds like the title of a children’s book, but like so much else that you learned in kindergarten, it’s true. Everyone’s body is different – but everyone’s endocannabinoid system is really unique. For reasons we don’t fully understand, receptors in the endocannabinoid system don’t respond predictably to cannabinoids from person to person. This lack of a predictable response makes standard dosing tricky.
Its sturdy fibers have also been put to growing use in high-quality plastics and auto paneling, durable building materials, and other common industrial commodities. And when it comes to environmental impact, hemp is not only a low-fuss crop capable of flourishing in US farmland; it can also clean up tainted water and soil, bully weeds away, and be converted into biodiesel.
Marijuana has in fact been grown for medicinal research in North America by both the Canadian (Fig. 40) and American governments, and this will likely continue. The possibility of marijuana becoming a legal commercial crop in North America is, to say the least, unlikely in the foreseeable future. Nevertheless the private sector is currently producing medicinal marijuana in Europe and Canada, so the following orientation to marijuana as a potential authorized crop is not merely academic.
There are hundreds of compounds in marijuana, but scientists believe the one responsible for the drugs' psychoactive effects is tetrahydrocannbinol, or THC. THC binds to cannabinoid receptors throughout the body, and marijuana's "high" comes from THC's binding to brain regions responsible for pleasure, time perception and pain, according to the National Institute on Drug Abuse (NIDA).
I can’t disagree more with attacking “Big Pharma” or Trump with regards to fixing this problem! Screw the political affiliations for now, let’s change the whole Schedule 1 nightmare. We’re steeped in technology and we have insanely archaic drug laws. Worse, our gov then pressures the countries we give money to (which is all of them) to follow suit by adopting our effed up way. Schedule 1 needs to be dismantled. The research can’t be done on anything listed with very few exceptions. There’s other Sched.1 drugs that need to be available for research by legitimate people, there’s lots of exciting research in psychedelics that’s stalled by archaic laws. That part might just require big pharma to help.
The genus Cannabis was formerly placed in the nettle (Urticaceae) or mulberry (Moraceae) family, and later, along with the genus Humulus (hops), in a separate family, the hemp family (Cannabaceae sensu stricto). Recent phylogenetic studies based on cpDNA restriction site analysis and gene sequencing strongly suggest that the Cannabaceae sensu stricto arose from within the former family Celtidaceae, and that the two families should be merged to form a single monophyletic family, the Cannabaceae sensu lato.
The effects of delta-9-THC and a synthetic agonist of the CB2 receptor were investigated in HCC. Both agents reduced the viability of HCC cells in vitro and demonstrated antitumor effects in HCC subcutaneous xenografts in nude mice. The investigations documented that the anti-HCC effects are mediated by way of the CB2 receptor. Similar to findings in glioma cells, the cannabinoids were shown to trigger cell death through stimulation of an endoplasmic reticulum stress pathway that activates autophagy and promotes apoptosis. Other investigations have confirmed that CB1 and CB2 receptors may be potential targets in non-small cell lung carcinoma  and breast cancer.
Earliest reference to euphoric use of C. sativa appears to date to China of 5 millennia ago, but it was in India over the last millennium that drug consumption became more firmly entrenched than anywhere else in the world. Not surprisingly, the most highly domesticated drug strains were selected in India. While C. sativa has been used as a euphoriant in India, the Near East, parts of Africa, and other Old World areas for thousands of years, such use simply did not develop in temperate countries where hemp was raised. The use of C. sativa as a recreational inebriant in sophisticated, largely urban settings is substantially a 20th century phenomenon.
The CBD oil needs to be taken twice a day everyday. The dosage depends on symptoms and it takes 30 days to awken your natural cannabis system after you begin taking the oil. I personally use Hemp works CBD oil in the 750 strength and only need 5 drops sublingual 2 times daily and results are many. Problem with oil and alz.patients is getting them to hold oil under tongue for 60 seconds. We have just began to get my dad on it. He too is in a nursing home in the state of florida and they cannot deny him any medication my mom has requested that he receive. If she is not their they are supposed to administer and she will call them to make sure he gets it. He is not 30 days into dosing yet so I don't have any results to speak of. I do know that since he has started he has had no more bladder infection and has not fallen in 3 weeks. That's a record for him so we will continue to monitor. Best of luck to you and a lot is going to depend on the state your mom is in and what the state laws are concerning her rights or the rights of whom has her medical power of attorney
CBD may also enhance uptake of cytotoxic drugs into malignant cells. Activation of the transient receptor potential vanilloid type 2 (TRPV2) has been shown to inhibit proliferation of human glioblastoma multiforme cells and overcome resistance to the chemotherapy agent carmustine.  One study showed that coadministration of THC and CBD over single-agent usage had greater antiproliferative activity in an in vitro study with multiple human glioblastoma multiforme cell lines. In an in vitro model, CBD increased TRPV2 activation and increased uptake of cytotoxic drugs, leading to apoptosis of glioma cells without affecting normal human astrocytes. This suggests that coadministration of CBD with cytotoxic agents may increase drug uptake and potentiate cell death in human glioma cells. Also, CBD together with THC may enhance the antitumor activity of classic chemotherapeutic drugs such as temozolomide in some mouse models of cancer.[13,33] A meta-analysis of 34 in vitro and in vivo studies of cannabinoids in glioma reported that all but one study confirmed that cannabinoids selectively kill tumor cells.
The endocannabinoid system is believed to be centrally involved in the regulation of mood and the extinction of aversive memories. Animal studies have shown CBD to have anxiolytic properties. It was shown in rats that these anxiolytic properties are mediated through unknown mechanisms. Anxiolytic effects of CBD have been shown in several animal models.[53,54]
It is not surprising that male-associated markers are relatively abundant. In dioecious plants where sex chromosomes have not been identified, markers for maleness indicate either the presence of sex chromosomes which have not been distinguished by cytological methods or that the marker is tightly linked to a gene involved in sex determination.
The term kief refers to the sticky, bulbous crystalline formations on the tip of a gland called a “trichome.” Trichomes are external resin glands packed with the chemicals that give marijuana its flavors and smells, called “terpenes.” They also contain high concentrations of cannabinoids. These chemicals which interact with our body to produce marijuana’s signature effects.
In early June, I met with Penny Pennington Howard, a mother of three, who lives in Carrollton, Texas, about 25 minutes outside of Dallas. Posted in the glass of her front door are two signs you can’t quite make out from the sidewalk: one asking visitors not to smoke, as oxygen treatments are in use; the other a yellow diamond informing guests this is the home of a special needs child. Penny welcomed me inside, out of the glare of the sun, and led me through her living room into her kitchen, where her kids were gathered for lunch. Seth, then eight months old, was plucking cereal off the tray of his highchair, while Lily, seven, was darting back and forth between the countertop and table. Harper, a blond five-year-old with hot pink toenails, was reclining in her “tomato chair,” a molded plastic seat with straps to help keep her steady.
Tocopherols. Tocopherols are major antioxidants in human serum. Alpha- beta-, gamma- and delta-tocopherol represent the vitamin E group. These fat-soluble vitamins are essential for human nutrition, especially the alpha-form, which is commonly called vitamin E. About 80% of the tocopherols of hempseed oil is the alpha form. The vitamin E content of hempseed is comparatively high. Antioxidants in hempseed oil are believed to stabilize the highly polyunsaturated oil, tending to keep it from going rancid. Sterols in the seeds probably serve the same function, and like the tocopherols are also desirable from a human health viewpoint.
Prescription medicine (Schedule 4) for therapeutic use containing 2 per cent (2.0%) or less of other cannabinoids commonly found in cannabis (such as ∆9-THC). A schedule 4 drug under the SUSMP is Prescription Only Medicine, or Prescription Animal Remedy – Substances, the use or supply of which should be by or on the order of persons permitted by State or Territory legislation to prescribe and should be available from a pharmacist on prescription.