Still, as the saying goes, absence of evidence isn’t necessarily evidence of absence, and there’s a reason we don’t have a ton of solid research on CBDs yet — “to study it, we need a good source, ” said Ziva Cooper, who is an associate professor at Columbia University and was on the National Academies committee. CBD is hard to get because it’s still technically a Schedule I drug, which limits its availability, Cooper said.
It was the seizures that tipped Penny off that something wasn’t right with Harper after she and her husband Dustin brought her home from the hospital as a newborn. Several months later, having tried a battery of epilepsy medications and still without a diagnosis, Penny and Dustin flew to Boston with Harper to see an expert in infant seizures. It was there they first heard of CDKL5. “This is the point where life changed significantly,” Penny said, “because now we had this diagnosis. You know, this abnormality in our family that we cannot fix.”
The applicant, including all corporate officers, must be fingerprinted at a law enforcement agency. The law enforcement agency, not the applicant, must send the fingerprint sheet to the Department (80-18-103, MCA). Most local law enforcement offices provide fingerprinting services. The completed application and copy of the law enforcement submitted fingerprints will be submitted for DEA review and approval. The DEA may place additional requirements on the Department or the applicant for participation or continuation of the program. At the end of the licensure, program participants must submit an agricultural/agronomic report regarding their experience with their hemp crop. The report shall include the approximate yield in pounds per acre and the method used to devitalize the seed. All seed must be devitalized after harvest and no seed production for future planting is allowed under the Montana Industrial Hemp Pilot Program.
Another clinical trial that involved 139 patients with HIV or AIDS and weight loss found that, compared with placebo, oral dronabinol was associated with a statistically significant increase in appetite after 4 to 6 weeks of treatment. Patients receiving dronabinol tended to have weight stabilization, whereas patients receiving placebo continued to lose weight.
Despite its designation as having no medicinal use, Cannabis was distributed by the U.S. government to patients on a case-by-case basis under the Compassionate Use Investigational New Drug program established in 1978. Distribution of Cannabis through this program was closed to new patients in 1992.[1-4] Although federal law prohibits the use of Cannabis, Figure 1 below shows the states and territories that have legalized Cannabis use for medical purposes. Additional states have legalized only one ingredient in Cannabis, such as cannabidiol (CBD), and are not included in the map. Some medical marijuana laws are broader than others, and there is state-to-state variation in the types of medical conditions for which treatment is allowed.
Hemp is grown in temperate zones as an annual cultivated from seed and can reach a height of up to 5 metres (16 feet). Crops grow best in sandy loam with good drainage and require average monthly rainfall of at least 65 mm (2.5 inches) throughout the growing season. Crops cultivated for fibre are densely sowed and produce plants averaging 2–3 metres (6–10 feet) tall with almost no branching. Plants grown for oilseed are planted farther apart and are shorter and many-branched. The slender stalks are hollow except at the tip and base. The leaves are compound with palmate shape, and the flowers are small and greenish yellow. Seed-producing flowers form elongate, spikelike clusters growing on the pistillate, or female, plants. Pollen-producing flowers form many-branched clusters on staminate, or male, plants. Maximum yield and quality are obtained by harvesting soon after the plants reach maturity, indicated by the full blossoms and freely shedding pollen of the male plants. Although sometimes pulled up by hand, plants are more often cut off about 2.5 cm (1 inch) above the ground.
Not until the end of the 20th century was the specific mechanism of action of THC at the neuronal level studied. Researchers have subsequently confirmed that THC exerts its most prominent effects via its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor, both of which are G protein-coupled receptors. The CB1 receptor is found primarily in the brain as well as in some peripheral tissues, and the CB2 receptor is found primarily in peripheral tissues, but is also expressed in neuroglial cells. THC appears to alter mood and cognition through its agonist actions on the CB1 receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose-dependent manner. These actions can be blocked by the selective CB1 receptor antagonist rimonabant (SR141716), which has been shown in clinical trials to be an effective treatment for smoking cessation, weight loss, and as a means of controlling or reducing metabolic syndrome risk factors. However, due to the dysphoric effect of CB1 receptor antagonists, this drug is often discontinued due to these side effects.
In addition to providing useful fibers, hemp seed also has high nutritional value. and the plant can be used to make biodegradable plastics, some fuels, and a variety of other things. Hemp foods including but not limited to hemp energy bars, hemp salad dressing,hemp milk, hemp protein shakes, hemp oil gel caps and hemp protein powder are among some of the health products being produced today. Visit the Hemp Education pages to learn more!
Unlike other Cannabis sativa varieties and hybrids, which are mostly grown for their chemically potent flowers (or 'buds'), hemp is also legally distinguished from marijuana in the US as containing less than 0.3% of the cannabinoid chemical THC — considered to be the most intoxicating, psychoactive component in cannabis plants, as well as a treatment option for certain serious illnesses.
The US Office of National Drug control Policy issued a statement on industrial hemp in 1997 (www.whitehousedrugpolicy.gov/policy/hemp%5Fold.html) which included the following: “Our primary concern about the legalization of the cultivation of industrial hemp (Cannabis sativa) is the message it would send to the public at large, especially to our youth at a time when adolescent drug use is rising rapidly... The second major concern is that legalizing hemp production may mean the de facto legalization of marijuana cultivation. Industrial hemp and marijuana are the product of the same plant, Cannabis sativa... Supporters of the hemp legalization effort claim hemp cultivation could be profitable for US farmers. However, according to the USDA and the US Department of Commerce, the profitability of industrial hemp is highly uncertain and probably unlikely. Hemp is a novelty product with limited sustainable development value even in a novelty market... For every proposed use of industrial hemp, there already exists an available product, or raw material, which is cheaper to manufacture and provides better market results.... Countries with low labor costs such as the Philippines and China have a competitive advantage over any US hemp producer.”
Market considerations also heavily determine the wisdom of investing in hemp. Growing hemp unfortunately has a magnetic attraction to many, so there is danger of overproduction. A marketing board could be useful to prevent unrestrained competition and price fluctuations, but is difficult to establish when the industry is still very small. As noted above, unwise investment in Canada produced a glut of seeds that resulted in price dumping and unprofitable levels for the majority. Cultural and production costs of hemp have been said to be comparable to those for corn, and while the truth of this remains to be confirmed, the legislative burden that accompanies hemp puts the crop at a unique disadvantage. Among the problems that Canadian farmers have faced are the challenge of government licensing (some delays, and a large learning curve), very expensive and sometime poor seed (farmers are not allowed to generate their own seed), teenagers raiding fields in the mistaken belief that marijuana is being grown, and great difficulties in exportation because of the necessity of convincing authorities that hemp is not a narcotic. Unless the producer participates in sharing of value-added income, large profits are unlikely. The industry widely recognizes that value added to the crop is the chief potential source of profit, as indeed for most other crops.
Nabiximols (Sativex), a Cannabis extract with a 1:1 ratio of THC:CBD, is approved in Canada (under the Notice of Compliance with Conditions) for symptomatic relief of pain in advanced cancer and multiple sclerosis. Canada, New Zealand, and some countries in Europe also approve nabiximols for spasticity of multiple sclerosis, a common symptom that may include muscle stiffness, reduced mobility, and pain, and for which existing therapy is unsatisfactory.
Essential (volatile) oil in hemp is quite different from hempseed oil. Examples of commercial essential oil product products are shown in Fig. 42. The essential oil is a mixture of volatile compounds, including monoterpenes, sesquiterpenes, and other terpenoid-like compounds that are manufactured in the same epidermal glands in which the resin of Cannabis is synthesized (Meier and Mediavilla 1998). Yields are very small—about 10 L/ha (Mediavilla and Steinemann 1997), so essential oil of C. sativa is expensive, and today is simply a novelty. Essential oil of different strains varies considerably in odor, and this may have economic importance in imparting a scent to cosmetics, shampoos, soaps, creams, oils, perfumes, and foodstuffs. Switzerland has been a center for the production of essential oil for the commercial market. Narcotic strains tend to be more attractive in odor than fiber strains, and because they produce much higher numbers of flowers than fiber strains, and the (female) floral parts provide most of the essential oil, narcotic strains are naturally adapted to essential oil production. Switzerland has permitted strains with higher THC content to be grown than is allowed in other parts of the world, giving the country an advantage with respect to the essential oil market. However, essential oil in the marketplace has often been produced from low-THC Cannabis, and the THC content of essential oil obtained by steam distillation can be quite low, producing a product satisfying the needs for very low THC levels in food and other commercial goods. The composition of extracted essential oil is quite different from the volatiles released around the fresh plant (particularly limonene and alpha-pinene), so that a pleasant odor of the living plant is not necessarily indicative of a pleasant-smelling essential oil. Essential oil has been produced in Canada by Gen-X Research Inc., Regina. The world market for hemp essential oil is very limited at present, and probably also has limited growth potential.
Cannabis is first referred to in Hindu Vedas between 2000 and 1400 BCE, in the Atharvaveda. By the 10th century CE, it has been suggested that it was referred to by some in India as "food of the gods". Cannabis use eventually became a ritual part of the Hindu festival of Holi. One of the earliest to use this plant in medical purposes was Korakkar, one of the 18 Siddhas. The plant is called Korakkar Mooli in the Tamil language, meaning Korakkar's herb.
Hemp is used to make a variety of commercial and industrial products including rope, textiles, clothing, shoes, food, paper, bioplastics, insulation, and biofuel. The bast fibers can be used to make textiles that are 100% hemp, but they are commonly blended with other fibers, such as flax, cotton or silk, as well as virgin and recycled polyester, to make woven fabrics for apparel and furnishings. The inner two fibers of the plant are more woody and typically have industrial applications, such as mulch, animal bedding and litter. When oxidized (often erroneously referred to as "drying"), hemp oil from the seeds becomes solid and can be used in the manufacture of oil-based paints, in creams as a moisturizing agent, for cooking, and in plastics. Hemp seeds have been used in bird feed mix as well. A survey in 2003 showed that more than 95% of hemp seed sold in the European Union was used in animal and bird feed.