I have had several neurological conditions like Bells Palsy three times, double vision, paralysis of left side of tongue. I have a lot of relief whenever I have pain by taking an inflamattory drug etoshine90 mg. Presently I have started taking Steroids for my facial palsy. The various pains I was having on the left side of neck, below the left ear, dizziness, pain around the head have subsided immidiately after the first dose of prendisolone 60 mg.I have read that CBD hemp oil can be useful for my condition of neurological and inflammation issues. My question is what concentrate (mg) of the oil should I take and for how long. Any brand that you may suggest that are available in the UK. Thank you.
For profitable hemp farming, particularly deep, humus-rich, nutrient-rich soil with controlled water flow is preferable. Waterlogged acidic, compressed or extremely light (sandy) soils primarily affect the early development of plants. Steep and high altitudes of more than 400 m above sea level are best avoided. Hemp is relatively insensitive to cold temperatures and can withstand frost down to −5 °C. Seeds can germinate down to 1–3 °C. Hemp needs a lot of heat, so earlier varieties come to maturation. The water requirement is 300–500 l/kg dry matter. This is around 1/14th that of cotton, which takes between 7,000 and 29,000 l/kg, according to WWF. Roots can grow up to 3 feet into the soil and use water from deeper soil layers.
Whether the drug and non-drug, cultivated and wild types of Cannabis constitute a single, highly variable species, or the genus is polytypic with more than one species, has been a subject of debate for well over two centuries. This is a contentious issue because there is no universally accepted definition of a species. One widely applied criterion for species recognition is that species are "groups of actually or potentially interbreeding natural populations which are reproductively isolated from other such groups." Populations that are physiologically capable of interbreeding, but morphologically or genetically divergent and isolated by geography or ecology, are sometimes considered to be separate species. Physiological barriers to reproduction are not known to occur within Cannabis, and plants from widely divergent sources are interfertile. However, physical barriers to gene exchange (such as the Himalayan mountain range) might have enabled Cannabis gene pools to diverge before the onset of human intervention, resulting in speciation. It remains controversial whether sufficient morphological and genetic divergence occurs within the genus as a result of geographical or ecological isolation to justify recognition of more than one species.
Let's start with the most officially proven medical use of CBD. Earlier this year, the FDA approved the first-ever drug containing CBD, Epidiolex, to treat two rare forms of pediatric epilepsy. To get to that point, the drug's manufacturers had to do a whole lot of randomized, placebo-controlled trials on humans. They had to study how much children could take, what would happen in case of overdose, and any possible side effects that would occur.
Textile expert Elizabeth Wayland Barber summarizes the historical evidence that Cannabis sativa, "grew and was known in the Neolithic period all across the northern latitudes, from Europe (Germany, Switzerland, Austria, Romania, Ukraine) to East Asia (Tibet and China)," but, "textile use of Cannabis sativa does not surface for certain in the West until relatively late, namely the Iron Age." "I strongly suspect, however, that what catapulted hemp to sudden fame and fortune as a cultigen and caused it to spread rapidly westwards in the first millennium B.C. was the spread of the habit of pot-smoking from somewhere in south-central Asia, where the drug-bearing variety of the plant originally occurred. The linguistic evidence strongly supports this theory, both as to time and direction of spread and as to cause."
An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic mammary cells. Other studies have also shown the antitumor effect of cannabinoids (i.e., CBD and THC) in preclinical models of breast cancer.[19,20]
CBD is a safe, long-term aid which is why it has gained such momentum and why our customers are turning to it for relief. CBD, scientifically known as cannabidiol, is a non-psychoactive, organic compound found in the hemp plant. When it interacts with the body’s endocannabinoid system, CBD provides powerful health benefits without the side effects of conventional drugs.
Until 2017, products containing cannabidiol that are marketed for medical purposes were classed as medicines by the UK regulatory body, the Medicines and Healthcare products Regulatory Agency (MHRA) and could not be marketed without regulatory approval for the medical claims. CBD oil with THC content not exceeding 0.2% was legalized throughout the UK in 2017. Cannabis oil, however, remained illegal to possess, buy and sell.
States have passed laws creating or allowing for the establishment of industrial hemp research or pilot programs. State agencies and institutions of higher education administer these programs in order to study the cultivation, processing, and economics of industrial hemp. Pilot programs may be limited to a certain period of time and may require periodic reporting from participants and state agencies. Some states establish specific regulatory agencies or committees, rules, and goals to oversee the research programs. States may also require coordination between specific colleges or universities and the programs, in other states coordination is optional. From 2015 to 2016, seven states enacted legislation to create hemp research or pilot programs, including Pennsylvania (H.B. 976) and Hawaii (S.B. 2659).
Applications and registration for an industrial hemp grower license and processor registration must be submitted during the open application period. The next application period will open on November 15th and will close February 15th. Your application must be complete, you must submit an aerial photograph of the growing area and payment. License fees for an industrial hemp growers license is $250-$350 depending on the size of the growing area. There is no fee for processor registration.
A combination of global overproduction of milk and increasing demand for non-dairy alternatives have crippled farmers whose livelihoods are often built on familial farms, passed down between generations. For many red-blooded farmers living in America's heartlands, agribusinesses are not just a means of putting food on the table. The legacy of farming runs through their veins, and the devastation happening within the industry is just as much a personal blow as it is a financial one.
The CBD utilized in our tinctures is extracted from industrial hemp cultivated in the United States. To further ensure quality and purity, our industrial hemp goes through a supercritical CO2 extraction process to obtain the best possible CBD solution. This solution is then formulated by our board-certified pharmacists into finished products and sent out for third-party testing. Our CBD oil is made with high-quality CBD extracted from organic hemp that is abundant in naturally produced terpenes, oils, vitamins, omega fatty acids, and other components.
Ten years ago hemp cultivation was illegal in Germany, England, Canada, Australia, and other countries. Essential to overcoming governmental reluctance in each country was the presentation of an image that was business-oriented, and conservative. The merits of environmentalism have acquired some political support, but unless there is a reasonable possibility that hemp cultivation is perceived as potentially economically viable, there is limited prospect of having anti-hemp laws changed. Strong support from business and farm groups is indispensable; support from pro-marijuana interests and what are perceived of as fringe groups is generally counterproductive. It is a combination of prospective economic benefit coupled with assurance that hemp cultivation will not detrimentally affect the enforcement of marijuana legislation that has led most industrially advanced countries to reverse prohibitions against growing hemp. Should the US permit commercial hemp cultivation to resume, it will likely be for the same reasons.
The objectivity of scientific evaluation of the medicinal value of marijuana to date has been questioned. In the words of Hirst et al. (1998): “The ...status of cannabis has made modern clinical research almost impossible. This is primarily because of the legal, ethical and bureaucratic difficulties in conducting trials with patients. Additionally, the general attitude towards cannabis, in which it is seen only as a drug of abuse and addiction, has not helped.” In a recent editorial, the respected journal Nature (2001) stated: “Governments, including the US federal government, have until recently refused to sanction the medical use of marijuana, and have also done what they can to prevent its clinical testing. They have defended their inaction by claiming that either step would signal to the public a softening of the so-called ‘war on drugs.’... The pharmacology of cannabinoids is a valid field of scientific investigation. Pharmacologists have the tools and the methodologies to realize its considerable potential, provided the political climate permits them to do so.” Given these current demands for research on medicinal marijuana, it will be necessary to produce crops of drug types of C. sativa.
Concrete-like blocks made with hemp and lime have been used as an insulating material for construction. Such blocks are not strong enough to be used for structural elements; they must be supported by a brick, wood, or steel frame. However, hemp fibres are extremely strong and durable, and have been shown to be usable as a replacement for wood for many jobs, including creating very durable and breathable homes. The most common use of hemp lime in building is by casting the hemp and lime mix while wet around a timber frame with temporary shuttering, and tamping the mix to form a firm mass; after the removal of the temporary shuttering, the solidified hemp mix is then ready to be plastered with a lime plaster.
I have lower back pain with some arthritis and arthritis in my hands.ive recently tried CBD Oil. It really does work. I have the drops and ointment. They both work. Because of the back pain I never would have been able to go on a hike with my family. We had a lot of fun. And "No Pain", all day. I'm also Type 2 diabetic. Anxious to see what my A1C is next month. I'm a believer.
Hemp is a multi-purpose agricultural crop delivering seeds, fibers and bio-active chemicals for a number of uses and markets. Industrial hemp is defined in federal and Montana statute as Cannabis sativa L. that contains no more than 0.3% delta-9 tetrahydrocannabinol (THC). Industrial hemp is authorized as an alternative agricultural crop by the Montana Legislature, Section 80-18-101 through 80-18-111 of Montana Code Annotated.
Despite advanced analytical techniques, much of the cannabis used recreationally is inaccurately classified. One laboratory at the University of British Columbia found that Jamaican Lamb’s Bread, claimed to be 100% sativa, was in fact almost 100% indica (the opposite strain). Legalization of cannabis in Canada (as of October 17, 2018) may help spur private-sector research, especially in terms of diversification of strains. It should also improve classification accuracy for cannabis used recreationally. Legalization coupled with Canadian government (Health Canada) oversight of production and labelling will likely result in more -- and more accurate -- testing to determine exact strains and content. Furthermore, the rise of craft cannabis growers in Canada should ensure quality, experimentation/research, and diversification of strains among private-sector producers.
In 2013, BMW announced its newest electric car, the i3. Using low-weight hemp in its interior, the i3 weighs 800 pounds less than its market competitors. The Kestrel, created by Canadian Motive Industries, uses polymer resin-infused hemp stalks to replace fiberglass in the body of the vehicle. From this replacement, consumers can expect a dramatic reduction in weight, improved efficiency and the appeal of an ecologically sustainable vehicle.
Despite advances in pharmacologic and nonpharmacologic management, nausea and vomiting (N/V) remain distressing side effects for cancer patients and their families. Dronabinol, a synthetically produced delta-9-THC, was approved in the United States in 1986 as an antiemetic to be used in cancer chemotherapy. Nabilone, a synthetic derivative of delta-9-THC, was first approved in Canada in 1982 and is now also available in the United States. Both dronabinol and nabilone have been approved by the U.S. Food and Drug Administration (FDA)for the treatment of N/V associated with cancer chemotherapy in patients who have failed to respond to conventional antiemetic therapy. Numerous clinical trials and meta-analyses have shown that dronabinol and nabilone are effective in the treatment of N/V induced by chemotherapy.[25-28] The National Comprehensive Cancer Network Guidelines recommend cannabinoids as breakthrough treatment for chemotherapy-related N/V. The American Society for Clinical Oncology (ASCO) antiemetic guidelines updated in 2017 recommends that the FDA-approved cannabinoids, dronabinol or nabilone, be used to treat N/V that is resistant to standard antiemetic therapies.
Scientists in Europe and North America concluded that hemp seed is an excellent source of nutrition. Numerous anecdotal incidences cited improvements in a wide range of acute and chronic conditions such as rapid healing of skin lesions and relief from flu, inflammation, and allergies. The benefits were attributed to the presence of rich source of the EFAs linoleic and alpha-linolenic acid, and their respective biologic metabolites, GLA and stearidonic acid.9
There are new CBD companies coming online every week – these span the range from truly awful to really great. So how to choose the best? The quality of the CBD oil itself is obviously the most important factor – and many companies do take the quality of their products seriously. To reward those companies, we gave more weight to the quality of the product than any other category.
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The question of whether heteromorphic sex chromosomes are indeed present is most conveniently answered if such chromosomes were clearly visible in a karyotype. Cannabis was one of the first plant species to be karyotyped; however, this was in a period when karyotype preparation was primitive by modern standards (see History of Cytogenetics). Heteromorphic sex chromosomes were reported to occur in staminate individuals of dioecious "Kentucky" hemp, but were not found in pistillate individuals of the same variety. Dioecious "Kentucky" hemp was assumed to use an XY mechanism. Heterosomes were not observed in analyzed individuals of monoecious "Kentucky" hemp, nor in an unidentified German cultivar. These varieties were assumed to have sex chromosome composition XX. According to other researchers, no modern karyotype of Cannabis had been published as of 1996. Proponents of the XY system state that Y chromosome is slightly larger than the X, but difficult to differentiate cytologically.
A limited number of studies have examined the effects of cannabis smoking on the respiratory system. Chronic heavy marijuana smoking is associated with coughing, production of sputum, wheezing, and other symptoms of chronic bronchitis. The available evidence does not support a causal relationship between cannabis use and chronic obstructive pulmonary disease. Short-term use of cannabis is associated with bronchodilation.
Various strains of "medical marijuana" are found to have a significant variation in the ratios of CBD-to-THC, and are known to contain other non-psychotropic cannabinoids. Any psychoactive marijuana, regardless of its CBD content, is derived from the flower (or bud) of the genus Cannabis. Non-psychoactive hemp (also commonly-termed industrial hemp), regardless of its CBD content, is any part of the cannabis plant, whether growing or not, containing a ∆-9 tetrahydrocannabinol concentration of no more than three-tenths of one percent (0.3%) on a dry weight basis. Certain standards are required for legal growing, cultivating and producing the hemp plant. The Colorado Industrial Hemp Program registers growers of industrial hemp and samples crops to verify that the THC concentration does not exceed 0.3% on a dry weight basis.
I had come to meet Dr. Angel Hernandez, the director of the hospital’s pediatric epilepsy program. A trail of wall-mounted signs led me to the pediatric neurology ward, a bright and airy space with flat-screen TVs running cartoons nonstop. Decorative kites were strung up in the corridors, and rainbow curtains lined the windows. Some of the kids in the waiting area that morning were alert and awake, others groggy. Some were strapped into special strollers designed for children with mobility problems, and some had shaven heads and healing scars. Hernandez came out to greet me, and I was surprised he recognized me after what felt like a very long time. He had diagnosed me with epilepsy in 2004 and treated me for several years.
It often takes 10 to 15 years for the industry associated with a new agricultural crop to mature. While it is true that foreign imports have been the basis for hemp products in North America for at least a decade, North American production is only 4 years of age in Canada, and farming of hemp in the US has not even begun. Viewed from this perspective, the hemp industry in North America is still very much in its infancy. Varieties of hemp specifically suited to given products and regions have only started to be developed in North America. There is considerable uncertainty regarding yields, costs of production, harvesting and processing equipment, product characteristics, foreign competition, governmental support, and the vagaries of the regulatory environment. Hemp is not presently a standard crop, and is likely to continue experiencing the risks inherent in a small niche market for some time. Hemp is currently a most uncertain crop, but has such a diversity of possible uses, is being promoted by extremely enthusiastic market developers, and attracts so much attention that it is likely to carve out a much larger share of the North American marketplace than its detractors are willing to concede.
Soil characteristics, latitude and climatic stresses have been found to have significant effects on THC concentrations, and there are seasonal and even diurnal variations (Small 1979; Pate 1998b). However, the range of THC concentrations developed by low-THC cultivars (those typically with £0.3% THC) under different circumstances on the whole is limited, for the most part generally not varying more than 0.2 percentage points when grown in a range of circumstances, and usually less (note information in Scheifle et al. 1999; Scheifle 2000, Scheifle and Dragla 2000). Practically, this has meant in Canadian experience that a few cultivars have been eliminated from further commercial cultivation because they sometimes exceed the 0.3% level (‘Fedora 19’ and ‘Futura,’ authorized in 2000, have now been removed because some test results in several years exceeded 0.3%; ‘Finola’ and ‘Uniko B’ are under probation because of elevated levels), but on the whole most of the permitted cultivars have maintained highly consistent development of quite low levels of THC.
^ Jump up to: a b Weinstein A, Livny A, Weizman A (2016). "Brain Imaging Studies on the Cognitive, Pharmacological and Neurobiological Effects of Cannabis in Humans: Evidence from Studies of Adult Users". Current Pharmaceutical Design. 22 (42): 6366–6379. doi:10.2174/1381612822666160822151323. PMID 27549374. 1)The studies reviewed so far demonstrated that chronic cannabis use has been associated with a volume reduction of the hippocampus...3)The overall conclusion arising from these studies is that recent cannabis users may experience subtle neurophysiological deficits while performing on working memory tasks, and that they compensate for these deficits by "working harder" by using additional brain regions to meet the demands of the task.
In 1976, Canadian botanist Ernest Small and American taxonomist Arthur Cronquist published a taxonomic revision that recognizes a single species of Cannabis with two subspecies: C. sativa L. subsp. sativa, and C. sativa L. subsp. indica (Lam.) Small & Cronq. The authors hypothesized that the two subspecies diverged primarily as a result of human selection; C. sativa subsp. sativa was presumably selected for traits that enhance fiber or seed production, whereas C. sativa subsp. indica was primarily selected for drug production. Within these two subspecies, Small and Cronquist described C. sativa L. subsp. sativa var. spontanea Vav. as a wild or escaped variety of low-intoxicant Cannabis, and C. sativa subsp. indica var. kafiristanica (Vav.) Small & Cronq. as a wild or escaped variety of the high-intoxicant type. This classification was based on several factors including interfertility, chromosome uniformity, chemotype, and numerical analysis of phenotypic characters.
The most widespread claim for environmental friendliness of hemp is that it has the potential to save trees that otherwise would be harvested for production of lumber and pulp. Earlier, the limitations of hemp as a pulp substitute were examined. With respect to wood products, several factors appear to favor increased use of wood substitutes, especially agricultural fibers such as hemp. Deforestation, particularly the destruction of old growth forests, and the world’s decreasing supply of wild timber resources are today major ecological concerns. Agroforestry using tree species is one useful response, but nevertheless sacrifices wild lands and biodiversity, and is less preferable than sustainable wildland forestry. The use of agricultural residues (e.g. straw bales in house construction) is an especially environmentally friendly solution to sparing trees, but material limitations restrict use. Another chief advantage of several annual fiber crops over forestry crops is relative productivity, annual fiber crops sometimes producing of the order of four times as much per unit of land. Still another important advantage is the precise control over production quantities and schedule that is possible with annual crops. In many parts of the world, tree crops are simply not a viable alternative. “By the turn of the century 3 billion people may live in areas where wood is cut faster than it grows or where fuelwood is extremely scarce” (World Commission on Environment and Development 1987). “Since mid-century, lumber use has tripled, paper use has increased six-fold, and firewood use has soared as Third World populations have multiplied” (Brown et al. 1998). Insofar as hemp reduces the need to harvest trees for building materials or other products, its use as a wood substitute will tend to contribute to preserving biodiversity. Hemp may also enhance forestry management by responding to short-term fiber demand while trees reach their ideal maturation. In developing countries where fuelwood is becoming increasingly scarce and food security is a concern, the introduction of a dual-purpose crop such as hemp to meet food, shelter, and fuel needs may contribute significantly to preserving biodiversity.
Fig. 6. ‘Finola,’ the first cultivar of Cannabis sativa bred exclusively for grain. (Courtesy of the breeder, J.C. Callaway, Univ. Kuopio, Finland.) Fig. 7. ‘Anka,’ the first registered North American bred cultivar of Cannabis sativa. This variety is best suited for grain production. (Courtesy of the breeder, P. Dragla, and of the Industrial Hemp Seed Development Company, Chatham, Ontario.)
CBD’s potential usefulness in treating certain conditions is yet another argument in favor of legalizing the entire cannabis plant. Removing cannabis from the federal list of Schedule I narcotics that are illegal under the Controlled Substances Act would allow scientists to research its full medical potential and pharmaceutical companies in the United States to develop marijuana-based drugs and submit them for FDA approval. Government-regulated labs could test products like CBD oil to ensure safety and quality. Doctors could prescribe marijuana- based medicines with full knowledge of potential side effects and drug interactions, and without fear of losing their medical licenses or being thrown in jail.
In 2012, voters in Colorado and Washington state passed initiatives legalizing cannabis for adults 21 and older under state law. In November 2014, Oregon, Alaska, and Washington D.C also approved recreational use of marijuana. In November 2016, four more states - California, Massachusetts, Maine, and Nevada - voted in recreational marijuana. It is important to note that the federal government still considers cannabis a dangerous drug and that the illegal distribution and sale of marijuana is a serious crime. Under the Controlled Substances Act (CSA), marijuana is still considered a Schedule 1 drug. Cultivation and distribution of marijuana are felonies; possession for personal use is a misdemeanor; possession of “paraphernalia” is also illegal. Cultivating 100 plants or more carries a mandatory minimum sentence of five years according to federal statutes.
The leaves have a peculiar and diagnostic venation pattern that enables persons poorly familiar with the plant to distinguish a cannabis leaf from unrelated species that have confusingly similar leaves (see illustration). As is common in serrated leaves, each serration has a central vein extending to its tip. However, the serration vein originates from lower down the central vein of the leaflet, typically opposite to the position of, not the first notch down, but the next notch. This means that on its way from the midrib of the leaflet to the point of the serration, the vein serving the tip of the serration passes close by the intervening notch. Sometimes the vein will actually pass tangent to the notch, but often it will pass by at a small distance, and when that happens a spur vein (occasionally a pair of such spur veins) branches off and joins the leaf margin at the deepest point of the notch. This venation pattern varies slightly among varieties, but in general it enables one to tell Cannabis leaves from superficially similar leaves without difficulty and without special equipment. Tiny samples of Cannabis plants also can be identified with precision by microscopic examination of leaf cells and similar features, but that requires special expertise and equipment.
The endocannabinoid system is believed to be centrally involved in the regulation of mood and the extinction of aversive memories. Animal studies have shown CBD to have anxiolytic properties. It was shown in rats that these anxiolytic properties are mediated through unknown mechanisms. Anxiolytic effects of CBD have been shown in several animal models.[53,54]
The most valid claims to environmental friendliness of hemp are with respect to agricultural biocides (pesticides, fungicides, herbicides). Cannabis sativa is known to be exceptionally resistant to pests (Fig. 51), although, the degree of immunity to attacking organisms has been greatly exaggerated, with several insects and fungi specializing on hemp. Despite this, use of pesticides and fungicides on hemp is usually unnecessary, although introduction of hemp to regions should be expected to generate local problems. Cannabis sativa is also relatively resistant to weeds, and so usually requires relatively little herbicide. Fields intended for hemp use are still frequently normally cleared of weeds using herbicides, but so long as hemp is thickly seeded (as is always done when hemp is grown for fiber), the rapidly developing young plants normally shade out competing weeds.
When oral Cannabis is ingested, there is a low (6%–20%) and variable oral bioavailability.[1,2] Peak plasma concentrations of delta-9-tetrahydrocannabinol (THC) occur after 1 to 6 hours and remain elevated with a terminal half-life of 20 to 30 hours. Taken by mouth, delta-9-THC is initially metabolized in the liver to 11-OH-THC, a potent psychoactive metabolite. Inhaled cannabinoids are rapidly absorbed into the bloodstream with a peak concentration in 2 to 10 minutes, declining rapidly for a period of 30 minutes and with less generation of the psychoactive 11-OH metabolite.
There is a general inverse relationship in the resin of Cannabis between the amounts of THC present and the amount of the other principal cannabinoid, CBD. Whereas most drug strains contain primarily THC and little or no CBD, fiber and oilseed strains primarily contain CBD and very little THC. CBD can be converted to THC by acid catalyzed cyclization, and so could serve as a starting material for manufacturing THC. In theory, therefore, low-THC cultivars do not completely solve the problem of drug abuse potential. In practice, however, the illicit drug trade has access to easier methods of synthesizing THC or its analogues than by first extracting CBD from non-drug hemp strains.
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