Its sturdy fibers have also been put to growing use in high-quality plastics and auto paneling, durable building materials, and other common industrial commodities. And when it comes to environmental impact, hemp is not only a low-fuss crop capable of flourishing in US farmland; it can also clean up tainted water and soil, bully weeds away, and be converted into biodiesel.
Cannabis for industrial uses is valuable in tens of thousands of commercial products, especially as fibre[106] ranging from paper, cordage, construction material and textiles in general, to clothing. Hemp is stronger and longer-lasting than cotton. It also is a useful source of foodstuffs (hemp milk, hemp seed, hemp oil) and biofuels. Hemp has been used by many civilizations, from China to Europe (and later North America) during the last 12,000 years.[106][107] In modern times novel applications and improvements have been explored with modest commercial success.[108][109]
Today, dozens of companies produce CBD in an array of forms. CBD can be inhaled through vape pens, applied in topical salves, ingested in edibles, or swallowed in oil-based tinctures. Oil has become the dominant CBD delivery method for kids with epilepsy, since it is easy to administer and ingest, and there is no shortage of it available for sale online. There are dozens of companies boasting names like Healthy Hemp Oil, Dose of Nature, and Natural Organic Solutions, each of them selling CBD products at prices ranging from trivial to dizzyingly steep. You don’t have to look hard to find them. If you have a PayPal account and $100 to spare, you could have a vial of hemp oil delivered to your doorstep.
Going forward, another emerging trend among recreational users are wellness lifestyles built around cannabis. This is certainly part of the influence of California’s new recreational marijuana market, which went online January 1, 2018. California is already an epicenter for health and wellness lifestyles and fads. Expect to see more of the same now that cannabis is completely legal.

In the end, companies like HempMedsPx are asking consumers simply to trust them. CBD oils are never subjected to systematic testing by any U.S. regulatory body. The FDA regulates all pharmaceutical labs in the country. But cannabis labs like the ones that HempMedsPx and others use are not, because cannabis is not federally recognized as a legal drug.
In the United States, non-FDA approved CBD products are classified as Schedule I drugs under the Controlled Substances Act.[63] This means that production, distribution, and possession of non-FDA approved CBD products is illegal under federal law. In addition, in 2016 the Drug Enforcement Administration added "marijuana extracts" to the list of Schedule I drugs, which it defined as "an extract containing one or more cannabinoids that has been derived from any plant of the genus Cannabis, other than the separated resin (whether crude or purified) obtained from the plant."[64] Previously, CBD had simply been considered "marijuana", which is a Schedule I drug.[63][65]
The more recently House-approved version, which introduced the well-publicized provision affecting up to two million Supplemental Nutrition Assistance Program (SNAP) recipients, doesn't take such steps to remove federal barriers around hemp. It also stipulates that anyone with a felony drug conviction would be barred indefinitely from participating in federal or state hemp programs.
When privacy isn’t a requirement, outdoor cannabis grows can provide many advantages over indoor operations. Sunlight is the single most important factor for successful outdoor marijuana growing. It’s important to choose a plot with total sunshine throughout the day. Therefore, cannabis growers in the northern hemisphere will want plots with southern exposure, exposing marijuana plants to the sun’s arc across the sky.
At least 38 states considered legislation related to industrial hemp in 2018. These bills ranged from clarifying existing laws to establishing new licensing requirements and programs. At least 5 states – Alaska, Arizona, Kansas, Missouri and Oklahoma – enacted legislation in 2018 establishing hemp research and industrial hemp pilot programs. Georgia adopted a resolution to create the House Study Committee on Industrial Hemp Production. States, already allowing for industrial hemp programs, continued to consider policies related to licensure, funding, seed certification, and other issues. For example, Tennessee amended its Commercial Feed Law to include hemp. 

No ongoing clinical trials of Cannabis as a treatment for cancer in humans were identified in a PubMed search. The only published trial of any cannabinoid in patients with cancer is a small pilot study of intratumoral injection of delta-9-THC in patients with recurrent glioblastoma multiforme, which demonstrated no significant clinical benefit.[19,20] In a trial (NCT02255292) conducted in Israel, oral cannabidiol (CBD) was investigated as a single salvage agent for recurrent solid tumors. The study was projected to be completed in 2015; however, no results have been published. A small exploratory phase II study (GWCA1208 Part A [NCT01812603]) was conducted in the United Kingdom that used nabiximols, a 1:1 ratio of THC:CBD in a Cannabis-based medicinal extract oromucosal spray, in conjunction with temozolomide in treating patients with recurrent glioblastoma multiforme. The study enrolled 21 patients. Final results have not been published.
My husband has RSD and we are considering CBD oil -= I would ask at Hempmed because the spray won't have enough in it. Our dgt';s friend has ovarian cancer and it is shrinking her tumors but the spray would never have been enough. I would get CBD oil and check with Hempmeds to see what they suggest. It isn't cheap but it does work. LOW dose Naltrexone about 4.5 mg is very helpful for RSD and is usually used for getting people off of drugs but is working on turning off the glial cells that surround the nerve that is causing the nerve to scream in pain. We are also using PeaPure that is out of the Netherlands and we are seeing a response, even though small. His other leg touched the painful leg without causing more severe pain. That is progress. We also are using Poison Ivy Cream through Meadowlake Farms that has helped the burning surface pain. Change your diet and get rid of Gluten and Sugar, anything that causes inflammation. This is to allow your own body to work. Absolutely do not use any pain killers as it will turn up your pain. all the Hydrocodone, etc causes neural inflammation and so it will keep cascading higher your pain. Hope this is helpful. Mary
In the meantime, some physicians are forging ahead — and cashing in. Joe Cohen is a doctor at Holos Health, a medical marijuana clinic in Boulder. I asked him what CBD is good for, and he read me a long list of conditions: pain, inflammation, nausea, vomiting, intestinal cramping, anxiety, psychosis, muscle spasms, hyperactive immune systems, nervous system degeneration, elevated blood sugar and more. He also claimed that CBD has anti-cancer properties and can regenerate brain cells and reduce the brain’s levels of amyloid beta — a kind of protein that’s been linked to Alzheimer’s disease. I asked for references, noting that most of these weren’t listed in the Academies report or a similar review published in the Journal of the American Medical Association. “I think you just have to Google search it,” he said. It’s true that a preliminary study found hints that cannabinoids might reduce beta amyloid proteins in human brain cells, but the study was done in cells grown in a lab, not in people. As for cancer, the FDA sent warning letters last year to four companies that were selling products that claimed to “prevent, diagnose, treat or cure” cancer.
Cannabinoids are known to interact with the hepatic cytochrome P450 enzyme system.[3,4] In one study, 24 cancer patients were treated with intravenous irinotecan (600 mg, n = 12) or docetaxel (180 mg, n = 12), followed 3 weeks later by the same drugs concomitant with medicinal Cannabis taken in the form of an herbal tea for 15 consecutive days, starting 12 days before the second treatment.[4] The administration of Cannabis did not significantly influence exposure to and clearance of irinotecan or docetaxel, although the herbal tea route of administration may not reproduce the effects of inhalation or oral ingestion of fat-soluble cannabinoids.
Plastic composites for automobiles are the second most important component of the hemp industry of the EU. Natural fibers in automobile composites are used primarily in press-molded parts (Fig. 18). There are two widespread technologies. In thermoplastic production, natural fibers are blended with polypropylene fibers and formed into a mat, which is pressed under heat into the desired form. In thermoset production the natural fibers are soaked with binders such as epoxy resin or polyurethane, placed in the desired form, and allowed to harden through polymerization. Hemp has also been used in other types of thermoplastic applications, including injection molding. The characteristics of hemp fibers have proven to be superior for production of molded composites. In European manufacturing of cars, natural fibers are used to reinforce door panels, passenger rear decks, trunk linings, and pillars. In 1999 over 20,000 t of natural fiber were used for these purposes in Europe, including about, 2,000 t of hemp. It has been estimated that 5–10 kg of natural fibers can be used in the molded portions of an average automobile (excluding upholstery). The demand for automobile applications of hemp is expected to increase considerably, depending on the development of new technologies (Karus et al. 2000).
CBD interacts with the body through the endogenous cannabinoid system (ECS) or endocannabinoid system. First discovered in the late 1980’s, the endocannabinoid system regulates the body’s homeostasis, or general state of balance, impacting such functions as mood, sleep, appetite, hormone regulation, and pain and immune response. Like an acrobat on a highwire, as the environment around us impacts our normal balance, the endocannabinoid system “corrects” by mediating our body’s reaction to keep us level.

Let's start with the most officially proven medical use of CBD. Earlier this year, the FDA approved the first-ever drug containing CBD, Epidiolex, to treat two rare forms of pediatric epilepsy. To get to that point, the drug's manufacturers had to do a whole lot of randomized, placebo-controlled trials on humans. They had to study how much children could take, what would happen in case of overdose, and any possible side effects that would occur.

Disclaimer: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.
Cannabis is predominantly dioecious,[12][14] having imperfect flowers, with staminate "male" and pistillate "female" flowers occurring on separate plants.[15] "At a very early period the Chinese recognized the Cannabis plant as dioecious",[16] and the (c. 3rd century BCE) Erya dictionary defined xi 枲 "male Cannabis" and fu 莩 (or ju 苴) "female Cannabis".[17] Male flowers are normally borne on loose panicles, and female flowers are borne on racemes.[18]
Cannabidiol is insoluble in water but soluble in organic solvents such as pentane. At room temperature, it is a colorless crystalline solid.[45] In strongly basic media and the presence of air, it is oxidized to a quinone.[46] Under acidic conditions it cyclizes to THC.[47] The synthesis of cannabidiol has been accomplished by several research groups.[48][49][50]
In Japan, hemp was historically used as paper and a fiber crop. There is archaeological evidence cannabis was used for clothing and the seeds were eaten in Japan back to the Jōmon period (10,000 to 300 BC). Many Kimono designs portray hemp, or asa (Japanese: 麻), as a beautiful plant. In 1948, marijuana was restricted as a narcotic drug. The ban on marijuana imposed by the United States authorities was alien to Japanese culture, as the drug had never been widely used in Japan before. Though these laws against marijuana are some of the world's strictest, allowing five years imprisonment for possession of the drug, they exempt hemp growers, whose crop is used to make robes for Buddhist monks and loincloths for Sumo wrestlers. Because marijuana use in Japan has doubled in the past decade, these exemptions have recently been called into question.[143]
Though use of marijuana among Washington state youth has remained relatively stable over the last several years (see Healthy Youth Survey), youth perception of harm from use of marijuana has been steadily decreasing (meaning: fewer adolescents believe marijuana use is harmful). Marijuana is the second most-commonly used substance among 12th graders (alcohol is the first), with 27% of high school seniors reporting current (past 30-day) use.
This summary is written and maintained by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® - NCI's Comprehensive Cancer Database pages.
Cannabis, also referred to as marijuana, has been an integral part of human civilizations for millennia. Both as a medicine and as a recreational substance, cannabis is the most popular illicit drug in the world. Today, the legal landscape that has prohibited marijuana for much of the twentieth century is giving way to decriminalization and full legalization. Legal, commercial cannabis businesses are already making an enormous economic impact.
For profitable hemp farming, particularly deep, humus-rich, nutrient-rich soil with controlled water flow is preferable. Waterlogged acidic, compressed or extremely light (sandy) soils primarily affect the early development of plants.[citation needed] Steep and high altitudes of more than 400 m above sea level are best avoided. Hemp is relatively insensitive to cold temperatures and can withstand frost down to −5 °C.[citation needed] Seeds can germinate down to 1–3 °C.[citation needed] Hemp needs a lot of heat, so earlier varieties come to maturation. The water requirement is 300–500 l/kg dry matter.[citation needed] This is around 1/14th that of cotton, which takes between 7,000 and 29,000 l/kg, according to WWF.[citation needed] Roots can grow up to 3 feet into the soil and use water from deeper soil layers.
It's the Wild West out there. Without any federal regulatory body checking labels, consumers have very little way of knowing what they're buying when they purchase CBD oil. Bonn-Miller co-authored a study that found that 26 percent of CBD products on the market contained less CBD than their label claimed. So the amount you need for an effective dose could vary drastically, not just from product to product, but from bottle to bottle of the same product.
Cannabis has mental and physical effects such as creating a "high" or "stoned" feeling, a general change in perception, heightened mood, and an increase in appetite.[21][22] Onset of effects is within minutes when smoked, and about 30 to 60 minutes when cooked and eaten.[21][23] They last for between two and six hours.[23] Short-term side effects may include a decrease in short-term memory, dry mouth, impaired motor skills, red eyes, and feelings of paranoia or anxiety.[21][24][25] Long-term side effects may include addiction, decreased mental ability in those who started as teenagers, and behavioral problems in children whose mothers used cannabis during pregnancy.[21] Studies have found a strong relation between cannabis use and the risk of psychosis,[26] though the cause-and-effect relationship is debated.[27]
Jump up ^ Juliet Eilperin (February 11, 2013), "'Good seed' versus 'evil weed': Hemp activists eye legalization", The Washington Post – via The Japan Times Online, [A] couple of factors — the high taxes the federal government imposed on growing hemp in the late 1930s and again in the early '50s, and then the DEA's interpretation of the 1970 law — made producing hemp nearly impossible. Since the DEA only grants permits in rare instances and demands costly, elaborate security precautions, large-scale hemp growing in the United States is not viable.
Cannabis is believed to be an aggravating factor in rare cases of arteritis, a serious condition that in some cases leads to amputation. Because 97% of case-reports also smoked tobacco, a formal association with cannabis could not be made. If cannabis arteritis turns out to be a distinct clinical entity, it might be the consequence of vasoconstrictor activity observed from delta-8-THC and delta-9-THC.[100] Other serious cardiovascular events including myocardial infarction, stroke,[101] sudden cardiac death, and cardiomyopathy have been reported to be temporally associated with cannabis use. Research in these events is complicated because cannabis is often used in conjunction with tobacco, and drugs such as alcohol and cocaine.[102] These putative effects can be taken in context of a wide range of cardiovascular phenomena regulated by the endocannabinoid system and an overall role of cannabis in causing decreased peripheral resistance and increased cardiac output, which potentially could pose a threat to those with cardiovascular disease.[103] There is some evidence from case reports that cannabis use may provoke fatal cardiovascular events in young people who have not been diagnosed with cardiovascular disease.[78] Smoking cannabis has also been shown to increase the risk of myocardial infarction by 4.8 times for the 60 minutes after consumption.[104]
Hemp is completely different from marijuana in its function, cultivation and application. But these differences didn’t stop our political leaders from getting confused and accidentally grouping all Cannabis species as a Schedule I Drug and banning it in 1970 under the Controlled Substances Act. Even after 45 years, the government still seems to have some confusion in distinguishing the two plants. Although legislation is being made, progress has been slow.In its application, hemp and marijuana serve completely different purposes. Marijuana, as it is widely known, is used for medicinal or recreational purposes. Hemp is used in variety of other applications that marijuana couldn’t possibly be used in. These include healthy dietary supplements, skin products, clothing, and accessories. Overall, hemp is known to have over 25,000 possible applications.
Edible cannabis, however, is quickly making up ground as a go-to method for consuming medical marijuana. Indeed, some states with legal medical marijuana laws still forbid smoking marijuana. Instead, medical forms of the drug are only available in pill or capsule form. Oils and tinctures, which are made from extracting cannabinoids from herbaceous material, are also commonly prescribed in the form of cannabis edibles.
The “re-“growth of industrial hemp in the United States is heavily regulated, although the neighbouring nation of Canada successfully grows hemp commercially.  Since becoming legal to grow again in Canada, the crop has taken off and has become a booming multi-million dollar export.  Hemp building materials are another growing segment of the hemp industry.  Canada is now a leader in the global hemp food/health marketplace.  Canadian hemp products can be found in many hemp markets now in the United States and the world over.
THC and its major (inactive) metabolite, THC-COOH, can be measured in blood, urine, hair, oral fluid or sweat using chromatographic techniques as part of a drug use testing program or a forensic investigation of a traffic or other criminal offense.[52] The concentrations obtained from such analyses can often be helpful in distinguishing active use from passive exposure, elapsed time since use, and extent or duration of use. These tests cannot, however, distinguish authorized cannabis smoking for medical purposes from unauthorized recreational smoking.[141] Commercial cannabinoid immunoassays, often employed as the initial screening method when testing physiological specimens for marijuana presence, have different degrees of cross-reactivity with THC and its metabolites.[142] Urine contains predominantly THC-COOH, while hair, oral fluid and sweat contain primarily THC.[52] Blood may contain both substances, with the relative amounts dependent on the recency and extent of usage.[52]
Pain management improves a patient’s quality of life throughout all stages of cancer. Through the study of cannabinoid receptors, endocannabinoids, and synthetic agonists and antagonists, the mechanisms of cannabinoid-induced analgesia have been analyzed.[46][Level of evidence:1iC] The CB1 receptor is found in the central nervous system (CNS) and in peripheral nerve terminals.[47] CB2 receptors are located mainly in peripheral tissue and are expressed in only low amounts in the CNS. Whereas only CB1 agonists exert analgesic activity in the CNS, both CB1 and CB2 agonists have analgesic activity in peripheral tissue.[48,49]
As the range of Tweed and CraftGrow brands and products will change in the Shop over time, we recommend the Spectrum Cannabis brand when consistent access to the same product is important to you and your condition. If you have been taking a Tweed product that is no longer carried or available in our store, we have created a comprehensive table for you to explore alternative options. The goal of this table is to support treatment decisions with products most similar to what you have been taking, when a change is necessary.  Learn More
I have idiopathic peripheral neuropathy ... the only thing they found that would work is lyrica. I picked up some CBD oil yesterday morning. I am prescribed to take 75 mg of lyrica 3x per day. I took one yesterday morning and have only used the CBD oil since. I bought the Koi brand, flavored, 250 MG. I used a full dropper yesterday late morning and a full dropper yesterday late afternoon. I used it once today (one full dropper) and I am amazingly pain free.
Given the uncertainties and handicaps associated with hemp, it is fortunate that there are compensating factors. As noted, as a crop hemp offers some real environmental advantages, particularly with regard to the limited needs for herbicides and pesticides. Hemp is therefore pre-adapted to organic agriculture, and accordingly to the growing market for products associated with environmentally-friendly, sustainable production. Hemp products are an advertiser’s dream, lending themselves to hyperbole (“healthiest salad oil in the world,” “toughest jeans on the market”). While the narcotics image of C. sativa is often disadvantageous, advertisers who choose to play up this association do so knowing that it will attract a segment of the consuming population. In general, the novelty of hemp means that many consumers are willing to pay a premium price. It might also be said that those who have entered the hemp industry have tended to be very highly motivated, resourceful, and industrious, qualities that have been needed in the face of rather formidable obstacles to progress.

The potential benefits of medicinal Cannabis for people living with cancer include antiemetic effects, appetite stimulation, pain relief, and improved sleep.[2] Although few relevant surveys of practice patterns exist, it appears that physicians caring for cancer patients in the United States who recommend medicinal Cannabis do so predominantly for symptom management.[3] A growing number of pediatric patients are seeking symptom relief with Cannabis or cannabinoid treatment, although studies are limited.[4] The American Academy of Pediatrics has not endorsed Cannabis and cannabinoid use because of concerns about brain development.
As provided in Sec. 7606 of the 2014 Farm Bill industrial hemp may only be grown as part of a research or pilot project.  The 108th General Assembly enacted Public Chapter 916 regarding the growing of industrial hemp in Tennessee. The Act removes industrial hemp from the definition of marijuana in the criminal code. The cultivation of industrial hemp is now available as an option for Tennessee farmers on a limited basis. The Commissioner of the Tennessee Department of Agriculture has promulgated regulations establishing a program of licensing authorized hemp producers.

38 states and Puerto Rico considered legislation related to industrial hemp in 2017. These bills ranged from clarifying existing laws to establishing new licensing requirements and programs.  At least 15 states enacted legislation in 2017 — Arkansas, Colorado, Florida, Hawaii, North Dakota, Nevada, New York, Oregon, South Carolina, Tennessee, Virginia, Washington, West Virginia, Wisconsin and Wyoming. Florida, Wisconsin and Nevada authorized new research or pilot programs. The governors of Arizona and New Mexico vetoed legislation, which would have established new research programs. 


In the end, companies like HempMedsPx are asking consumers simply to trust them. CBD oils are never subjected to systematic testing by any U.S. regulatory body. The FDA regulates all pharmaceutical labs in the country. But cannabis labs like the ones that HempMedsPx and others use are not, because cannabis is not federally recognized as a legal drug.
Liquid CBD Oil/Tinctures/Extracts: Drops or tinctures should have a “suggested serving size” and the total milligrams of CBD listed on their packaging. From there, you can determine the amount of CBD you would like to ingest. Simply place the correct quantity of drops under your tongue using the dropper and hold the CBD oil in place for a minimum of 60 seconds. The 60 second hold allows for absorption via the blood vessels underneath your tongue – efficiently bypassing first-pass metabolism. Once 60 seconds has passed, swallow the CBD oil.
Put simply, “indica” strains are those associated with a strong body-high, feelings of sedation and relaxation. For this reason, indicas are often thought of as the “heavier” strains of cannabis, offering stronger highs that impact the whole body. They’re popular among marijuana users as pain relieving and sleep-inducing strains. Indicas are especially popular among medical cannabis patients.
Environmental sex determination is known to occur in a variety of species.[38] Many researchers have suggested that sex in Cannabis is determined or strongly influenced by environmental factors.[26] Ainsworth reviews that treatment with auxin and ethylene have feminizing effects, and that treatment with cytokinins and gibberellins have masculinizing effects.[14] It has been reported that sex can be reversed in Cannabis using chemical treatment.[39] A PCR-based method for the detection of female-associated DNA polymorphisms by genotyping has been developed.[40]
Cannabis is indigenous to Central Asia and Indian subcontinent,[183] and its use for fabric and rope dates back to the Neolithic age in China and Japan.[184][185] It is unclear when cannabis first became known for its psychoactive properties; some scholars suggest that the ancient Indian drug soma, mentioned in the Vedas, was cannabis, although this theory is disputed.[186]

Cannabis use for medicinal purposes dates back at least 3,000 years.[1-5] It was introduced into Western medicine in 1839 by W.B. O’Shaughnessy, a surgeon who learned of its medicinal properties while working in India for the British East India Company. Its use was promoted for reported analgesic, sedative, anti-inflammatory, antispasmodic, and anticonvulsant effects.


Karl W. Hillig, a graduate student in the laboratory of long-time Cannabis researcher Paul G. Mahlberg[77] at Indiana University, conducted a systematic investigation of genetic, morphological, and chemotaxonomic variation among 157 Cannabis accessions of known geographic origin, including fiber, drug, and feral populations. In 2004, Hillig and Mahlberg published a chemotaxonomic analysis of cannabinoid variation in their Cannabis germplasm collection. They used gas chromatography to determine cannabinoid content and to infer allele frequencies of the gene that controls CBD and THC production within the studied populations, and concluded that the patterns of cannabinoid variation support recognition of C. sativa and C. indica as separate species, but not C. ruderalis.[52] The authors assigned fiber/seed landraces and feral populations from Europe, Central Asia, and Turkey to C. sativa. Narrow-leaflet and wide-leaflet drug accessions, southern and eastern Asian hemp accessions, and feral Himalayan populations were assigned to C. indica. In 2005, Hillig published a genetic analysis of the same set of accessions (this paper was the first in the series, but was delayed in publication), and proposed a three-species classification, recognizing C. sativa, C. indica, and (tentatively) C. ruderalis.[55] In his doctoral dissertation published the same year, Hillig stated that principal components analysis of phenotypic (morphological) traits failed to differentiate the putative species, but that canonical variates analysis resulted in a high degree of discrimination of the putative species and infraspecific taxa.[78] Another paper in the series on chemotaxonomic variation in the terpenoid content of the essential oil of Cannabis revealed that several wide-leaflet drug strains in the collection had relatively high levels of certain sesquiterpene alcohols, including guaiol and isomers of eudesmol, that set them apart from the other putative taxa.[79] Hillig concluded that the patterns of genetic, morphological, and chemotaxonomic variation support recognition of C. sativa and C. indica as separate species. He also concluded there is little support to treat C. ruderalis as a separate species from C. sativa at this time, but more research on wild and weedy populations is needed because they were underrepresented in their collection.
Not until the end of the 20th century was the specific mechanism of action of THC at the neuronal level studied.[citation needed] Researchers have subsequently confirmed that THC exerts its most prominent effects via its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor, both of which are G protein-coupled receptors.[133] The CB1 receptor is found primarily in the brain as well as in some peripheral tissues, and the CB2 receptor is found primarily in peripheral tissues, but is also expressed in neuroglial cells.[134] THC appears to alter mood and cognition through its agonist actions on the CB1 receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose-dependent manner. These actions can be blocked by the selective CB1 receptor antagonist rimonabant (SR141716), which has been shown in clinical trials to be an effective treatment for smoking cessation, weight loss, and as a means of controlling or reducing metabolic syndrome risk factors.[135] However, due to the dysphoric effect of CB1 receptor antagonists, this drug is often discontinued due to these side effects.[136]

The “re-“growth of industrial hemp in the United States is heavily regulated, although the neighbouring nation of Canada successfully grows hemp commercially.  Since becoming legal to grow again in Canada, the crop has taken off and has become a booming multi-million dollar export.  Hemp building materials are another growing segment of the hemp industry.  Canada is now a leader in the global hemp food/health marketplace.  Canadian hemp products can be found in many hemp markets now in the United States and the world over.

In late 2017, researchers with the University of Guelph in Canada published the first-ever study to document the ideal growing conditions for cannabis. Using liquid organic fertilizer with a PKN ratio of 1.3P–1.7K-4.0N, the experiment tested five increasing rates of fertilization. They also tested two coir-based soil-less growing media, or “substrates.”
Understanding the mechanism of cannabinoid-induced analgesia has been increased through the study of cannabinoid receptors, endocannabinoids, and synthetic agonists and antagonists. Cannabinoids produce analgesia through supraspinal, spinal, and peripheral modes of action, acting on both ascending and descending pain pathways.[41] The CB1 receptor is found in both the central nervous system (CNS) and in peripheral nerve terminals. Similar to opioid receptors, increased levels of the CB1 receptor are found in regions of the brain that regulate nociceptive processing.[42] CB2 receptors, located predominantly in peripheral tissue, exist at very low levels in the CNS. With the development of receptor-specific antagonists, additional information about the roles of the receptors and endogenous cannabinoids in the modulation of pain has been obtained.[43,44]
Foreign sources, China in particular, can produce hemp seed cheaply, but imported seed must be sterilized, and the delays this usually requires are detrimental. Seed that has been sterilized tends to go rancid quickly, and so it is imperative that fresh seed be available, a great advantage for domestic production. An additional extremely significant advantage that domestic producers have over foreign sources is organic production, which is important for the image desired by the hemp food market. Organic certification is much more reliable in North America than in the foreign countries that offer cheap seeds. Whereas China used to supply most of the hempseed used for food in North America, Canadian-grown seeds have taken over this market.
Hash oil is a resinous matrix of cannabinoids obtained from the Cannabis plant by solvent extraction,[175] formed into a hardened or viscous mass.[176] Hash oil can be the most potent of the main cannabis products because of its high level of psychoactive compound per its volume, which can vary depending on the plant's mix of essential oils and psychoactive compounds.[177] Butane and supercritical carbon dioxide hash oil have become popular in recent years.[178]

It was the seizures that tipped Penny off that something wasn’t right with Harper after she and her husband Dustin brought her home from the hospital as a newborn. Several months later, having tried a battery of epilepsy medications and still without a diagnosis, Penny and Dustin flew to Boston with Harper to see an expert in infant seizures. It was there they first heard of CDKL5. “This is the point where life changed significantly,” Penny said, “because now we had this diagnosis. You know, this abnormality in our family that we cannot fix.”
Jump up ^ Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Kitamura Y, Uchida N, Nishimura R, Egashira N, Iwasaki K, Fujiwara M (January 2008). "Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism". Brain Research. 1188: 157–64. doi:10.1016/j.brainres.2007.09.090. PMID 18021759.
Some users may experience an episode of acute psychosis, which usually abates after six hours, but in rare instances, heavy users may find the symptoms continuing for many days.[52] A reduced quality of life is associated with heavy cannabis use, although the relationship is inconsistent and weaker than for tobacco and other substances.[53] It is unclear, however, if the relationship is cause and effect.[53]
Former President Barack Obama defined industrial hemp as a distinct crop from marijuana in the 2014 U.S. Farm Bill, authorizing higher education institutions and state agricultural departments to give the green light to "regulate and conduct research and pilot programs." But with its classification as a Schedule 1 drug still in effect, the path toward cultivating industrial hemp hasn't been an easy one.
The 2014 Farm Bill included a section to allow for universities and state departments of agriculture to begin cultivating industrial hemp for purposes of research, provided that the growing and cultivating of industrial hemp is allowed under state law. Industrial hemp is defined by SB 263 as all parts and varieties of the plant cannabis sativa L that contain a delta-9 tetrahydrocannabinol (THC) concentration of no more than 0.3 percent on a dry weight basis.
Of course, parents who desperately want to find something—anything—that will help their sick children, don’t have the luxury of caring whether CBD is classified as a drug or a supplement, or whether they get it from a doctor or an online retailer. One reason why people are willing to trust companies like HempMedsPx is that, for some, CBD oil does seem to work.
Cannabis impairs psychomotor performance in a wide variety of tasks, such as motor coordination, divided attention, and operative tasks of many types; human performance on complex machinery can be impaired for as long as 24 hours after smoking as little as 20 mg of THC in cannabis; there is an increased risk of motor vehicle accidents among persons who drive when intoxicated by cannabis.
"Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia.
It is clear that there is a culture of idealistic believers in hemp in North America, and that there is great determination to establish the industry. As history has demonstrated, unbridled enthusiasm for largely untested new crops touted as gold mines sometimes leads to disaster. The attempt to raise silk in the US is probably the most egregious example. In 1826 a Congressional report that recommended the preparation of a practical manual on the industry resulted in a contagious desire to plant mulberries for silk production, with the eventual collapse of the industry, the loss of fortunes, and a legacy of “Mulberry Streets” in the US (Chapter 2, Bailey 1898). In the early 1980s in Minnesota, Jerusalem artichoke was touted as a fuel, a feed, a food, and a sugar crop. Unfortunately there was no market for the new “wonder crop” and hundreds of farmers lost about $20 million (Paarlberg 1990). The level of “hype” associated with industrial hemp is far more than has been observed before for other new crops (Pinfold Consulting 1998). Probably more so than any plant in living memory, hemp attracts people to attempt its cultivation without first acquiring a realistic appreciation of the possible pitfalls. American presidents George Washington and Thomas Jefferson encouraged the cultivation of hemp, but both lost money trying to grow it. Sadly in Canada in 1999 numerous farmers contracted to grow half of Canada’s crop area for hemp for the American-based Consolidated Growers and Processors, and with the collapse of the firm were left holding very large amounts of unmarketable grain and baled hemp straw. This has represented a most untimely setback for a fledgling industry, but at least has had a sobering effect on investing in hemp. In this section we emphasize why producers should exercise caution before getting into hemp.
That leaves those touting CBD’s effectiveness pointing primarily to research in mice and petri dishes. There, CBD (sometimes combined with small amounts of THC) has shown promise for helping pain, neurological conditions like anxiety and PTSD, and the immune system—and therefore potentially arthritis, diabetes, multiple sclerosis, cancer, and more.
It sounds like the title of a children’s book, but like so much else that you learned in kindergarten, it’s true. Everyone’s body is different – but everyone’s endocannabinoid system is really unique. For reasons we don’t fully understand, receptors in the endocannabinoid system don’t respond predictably to cannabinoids from person to person. This lack of a predictable response makes standard dosing tricky.
CBD concentrates typically contain the strongest dosage of CBD compared to any other CBD products. It can contain up to 10 times the average CBD products. Concentrates are also convenient in that it only takes a few seconds to consume. Overall, CBD concentrates seem to be most popular among customers who are extremely busy, yet seek high potency CBD.
Cannabis, (genus Cannabis), plant belonging to the family Cannabaceae of the nettle order (Urticales). By some classifications, the genus Cannabis comprises a single species, hemp (Cannabis sativa), a stout, aromatic, erect annual herb that originated in Central Asia and is now cultivated worldwide, including in Europe, southern Asia, the Middle East, India, Africa, and the Americas. A tall canelike variety is raised for the production of hemp fibre, while the female plant of a short branchier variety is prized as the more abundant source of the psychoactive substance tetrahydrocannabinol (THC), the active ingredient of marijuana.
My mom is late stage dementia. We have tried coconut oil/black pepper/curcumin combo for years. Gives only tine bit of help, and is not something that reverses dementia. Maybe in someone who can score better than a 14 on the mme it could be of help. But cannabinoid is a different story. Cannabinoids produce better results in less time. Can't say yet that they will reverse anything though.
Essential (volatile) oil in hemp is quite different from hempseed oil. Examples of commercial essential oil product products are shown in Fig. 42. The essential oil is a mixture of volatile compounds, including monoterpenes, sesquiterpenes, and other terpenoid-like compounds that are manufactured in the same epidermal glands in which the resin of Cannabis is synthesized (Meier and Mediavilla 1998). Yields are very small—about 10 L/ha (Mediavilla and Steinemann 1997), so essential oil of C. sativa is expensive, and today is simply a novelty. Essential oil of different strains varies considerably in odor, and this may have economic importance in imparting a scent to cosmetics, shampoos, soaps, creams, oils, perfumes, and foodstuffs. Switzerland has been a center for the production of essential oil for the commercial market. Narcotic strains tend to be more attractive in odor than fiber strains, and because they produce much higher numbers of flowers than fiber strains, and the (female) floral parts provide most of the essential oil, narcotic strains are naturally adapted to essential oil production. Switzerland has permitted strains with higher THC content to be grown than is allowed in other parts of the world, giving the country an advantage with respect to the essential oil market. However, essential oil in the marketplace has often been produced from low-THC Cannabis, and the THC content of essential oil obtained by steam distillation can be quite low, producing a product satisfying the needs for very low THC levels in food and other commercial goods. The composition of extracted essential oil is quite different from the volatiles released around the fresh plant (particularly limonene and alpha-pinene), so that a pleasant odor of the living plant is not necessarily indicative of a pleasant-smelling essential oil. Essential oil has been produced in Canada by Gen-X Research Inc., Regina. The world market for hemp essential oil is very limited at present, and probably also has limited growth potential.
Synthetic cannabis is illegal in New Zealand. It is designed to imitate the effects of cannabis and is usually dried plant material sprayed with chemicals known as synthetic cannabinoids. It is also available in liquid form. Little is known about the chemicals used in synthetic cannabis and the effects can be unpredictable, especially when mixed with other substances.

Content updates feature essential information related to the state’s commercial cannabis regulations and guidelines, the licensing application process, and announcements from the state’s three cannabis licensing authorities and business partners. Links to each state agency’s cannabis information are listed towards to the bottom of the homepage under the “Collaborating State Agencies” header. 
A mixture of fiberglass, hemp fiber, kenaf, and flax has been used since 2002 to make composite panels for automobiles.[34] The choice of which bast fiber to use is primarily based on cost and availability. Various car makers are beginning to use hemp in their cars, including Audi, BMW, Ford, GM, Chrysler, Honda, Iveco, Lotus, Mercedes, Mitsubishi, Porsche, Saturn, Volkswagen[35] and Volvo. For example, the Lotus Eco Elise[36] and the Mercedes C-Class both contain hemp (up to 20 kg in each car in the case of the latter).[37]
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