At least 50% of patients who receive moderately emetogenic chemotherapy may experience delayed chemotherapy-induced N/V. Although selective neurokinin 1 antagonists that inhibit substance P have been approved for delayed N/V, a study was conducted before their availability to assess dronabinol, ondansetron, or their combination in preventing delayed-onset chemotherapy-induced N/V.[34] Ondansetron, a serotonin 5-hydroxytryptamine 3 (5-HT3) receptor antagonist, is one of the mainstay agents in the current antiemetic armamentarium. In this trial, the primary objective was to assess the response 2 to 5 days after moderately to severely emetogenic chemotherapy. Sixty-one patients were analyzed for efficacy. The total response–a composite endpoint–including nausea intensity, vomiting/retching, and use of rescue medications, was similar with dronabinol (54%), ondansetron (58%), and combination therapy (47%) when compared with placebo (20%). Nausea absence was greater in the active treatment groups (dronabinol 71%, ondansetron 64%, combination therapy 53%) when compared with placebo (15%; P < .05 vs. placebo for all). Occurrence rates for nausea intensity and vomiting/retching episodes were the lowest in patients treated with dronabinol, suggesting that dronabinol compares favorably with ondansetron in this situation where a substance P inhibitor would currently be the drug of choice.
This law provides a framework for commercial industrial hemp production in Montana following approval by the federal government. Provisions added to the 2014 Farm Bill (Section 7606) defined industrial hemp under federal law and recognized state agricultural departments' authority to develop research pilot programs to study the growth, cultivation, and/or marketing of industrial hemp.
In December 2012, the U.S. state of Washington became the first state to officially legalize cannabis in a state law (Washington Initiative 502) (but still illegal by federal law),[215] with the state of Colorado following close behind (Colorado Amendment 64).[216] On January 1, 2013, the first marijuana "club" for private marijuana smoking (no buying or selling, however) was allowed for the first time in Colorado.[217] The California Supreme Court decided in May 2013 that local governments can ban medical marijuana dispensaries despite a state law in California that permits the use of cannabis for medical purposes. At least 180 cities across California have enacted bans in recent years.[218]
To illustrate how hemp programs can wither without proper support, she pointed to California, where regulators continue struggling to keep up with rules and infrastructure for the more potent (and popular) marijuana industry, from lab tests to license approvals; the state's hemp operators, meanwhile, are still waiting for their official license application to come out.
Hemp has been grown for millennia in Asia and the Middle East for its fibre. Commercial production of hemp in the West took off in the eighteenth century, but was grown in the sixteenth century in eastern England.[140] Because of colonial and naval expansion of the era, economies needed large quantities of hemp for rope and oakum. In the early 1940s, world production of hemp fiber ranged from 250 000 to 350 000 metric tonnes, Russia was the biggest producer.[125]
A mixture of fiberglass, hemp fiber, kenaf, and flax has been used since 2002 to make composite panels for automobiles.[34] The choice of which bast fiber to use is primarily based on cost and availability. Various car makers are beginning to use hemp in their cars, including Audi, BMW, Ford, GM, Chrysler, Honda, Iveco, Lotus, Mercedes, Mitsubishi, Porsche, Saturn, Volkswagen[35] and Volvo. For example, the Lotus Eco Elise[36] and the Mercedes C-Class both contain hemp (up to 20 kg in each car in the case of the latter).[37]
Royal Queen Seeds CBD Oil offers a convenient, discreet and quick way to dose yourself with a bit of CBD, no matter your situation or where you are. All of our CBD oil is created using organically grown hemp sourced from right here in Europe, extracted using the latest CO² techniques. It means our oil is 100% natural, offering pure and strong CBD. All you need to do as drop you dose under your tongue or in your food, and away you go!
Medical cannabis (or medical marijuana) refers to the use of cannabis and its constituent cannabinoids, to treat disease or improve symptoms. Cannabis is used to reduce nausea and vomiting during chemotherapy, to improve appetite in people with HIV/AIDS, and to treat chronic pain and muscle spasms.[102][103] Cannabinoids are under preliminary research for their potential to affect stroke.[104]
Hashish (also spelled hasheesh, hashisha, or simply hash) is a concentrated resin cake or ball produced from pressed kief, the detached trichomes and fine material that falls off cannabis flowers and leaves.[169] or from scraping the resin from the surface of the plants and rolling it into balls. It varies in color from black to golden brown depending upon purity and variety of cultivar it was obtained from.[170] It can be consumed orally or smoked, and is also vaporised, or 'vaped'.[171] The term "rosin hash" refers to a high quality solventless product obtained through heat and pressure.[172]
In some areas where cannabis use had been historically tolerated, new restrictions were instituted, such as the closing of cannabis coffee shops near the borders of the Netherlands,[210] and closing of coffee shops near secondary schools in the Netherlands.[211] In Copenhagen, Denmark in 2014, mayor Frank Jensen discussed possibilities for the city to legalize cannabis production and commerce.[212]
In Europe and Asia, hemp farming has been conducted for millennia. Although most countries ceased growing hemp after the second word war, some didn’t, including France, China, Russia, and Hungary, so that essential knowledge of how to grow and process hemp was maintained. When commercial hemp cultivation resumed in Canada in 1997, many farmers undertook to grow the crop without appreciating its suitability for their situation, or for the hazards of an undeveloped market. Hemp was often grown on farms with marginal incomes in the hopes that it was a savior from a downward financial spiral. The myth that hemp is a wonder crop that can be grown on any soil led some to cultivate on soils with a history of producing poor crops; of course, a poor crop was the result.
Yet, even with this progress, hemp businesses seem to face difficulty expanding in the US as they face challenges in traditional marketing and sales approaches. According to a case study done by Forbes, hemp businesses and startups have had difficulty marketing and selling non-psychoactive hemp products, as some online advertising platforms and financial institutions do not distinguish between hemp and marijuana.[100]
CBD has also been demonstrated to exert a chemopreventive effect in a mouse model of colon cancer.[21] In this experimental system, azoxymethane increased premalignant and malignant lesions in the mouse colon. Animals treated with azoxymethane and CBD concurrently were protected from developing premalignant and malignant lesions. In in vitro experiments involving colorectal cancer cell lines, the investigators found that CBD protected DNA from oxidative damage, increased endocannabinoid levels, and reduced cell proliferation. In a subsequent study, the investigators found that the antiproliferative effect of CBD was counteracted by selective CB1 but not CB2 receptor antagonists, suggesting an involvement of CB1 receptors.[22]
The United Kingdom and Germany resumed commercial production in the 1990s. British production is mostly used as bedding for horses; other uses are under development. Companies in Canada, the UK, the United States, and Germany, among many others, process hemp seed into a growing range of food products and cosmetics; many traditional growing countries still continue to produce textile-grade fibre.
The importation and movement of hemp seeds and plants is restricted under federal law. According to the Statement of Principles on Industrial Hemp (81 Federal Register (FR) 53395) issued by the U.S. Department of Agriculture, U.S. Drug Enforcement Administration, and U.S. Food and Drug Administration, "industrial hemp plants and seeds may not be transported across State lines." For more information, contact the U.S. Drug Enforcement Administration.
Hemp crops are tall, have thick foliage, and can be planted densely, and thus can be grown as a smother crop to kill tough weeds.[45] Using hemp this way can help farmers avoid the use of herbicides, gain organic certification, and gain the benefits of crop rotation. However, due to the plant's rapid and dense growth characteristics, some jurisdictions consider hemp a prohibited and noxious weed, much like Scotch Broom.[citation needed]

Cannabis is frequently used among Sufis[131] – the mystical interpretation of Islam that exerts strong influence over local Muslim practices in Bangladesh, India, Indonesia, Turkey, and Pakistan. Cannabis preparations are frequently used at Sufi festivals in those countries.[131] Pakistan's Shrine of Lal Shahbaz Qalandar in Sindh province is particularly renowned for the widespread use of cannabis at the shrine's celebrations, especially its annual Urs festival and Thursday evening dhamaal sessions - or meditative dancing sessions.[132][133]


Another field in which CBD is creating a buzz is in the area of mood disorders like anxiety and depression. Both conditions have been treated with a variety of medications, courtesy of Big Pharma, that have had varying levels of success. Again, the long list of side effects can be off-putting to someone who just wants to get through the day without the sweaty tension of anxiety or the gray haze of depression.
At least 50% of patients who receive moderately emetogenic chemotherapy may experience delayed chemotherapy-induced N/V. Although selective neurokinin 1 antagonists that inhibit substance P have been approved for delayed N/V, a study was conducted before their availability to assess dronabinol, ondansetron, or their combination in preventing delayed-onset chemotherapy-induced N/V.[34] Ondansetron, a serotonin 5-hydroxytryptamine 3 (5-HT3) receptor antagonist, is one of the mainstay agents in the current antiemetic armamentarium. In this trial, the primary objective was to assess the response 2 to 5 days after moderately to severely emetogenic chemotherapy. Sixty-one patients were analyzed for efficacy. The total response–a composite endpoint–including nausea intensity, vomiting/retching, and use of rescue medications, was similar with dronabinol (54%), ondansetron (58%), and combination therapy (47%) when compared with placebo (20%). Nausea absence was greater in the active treatment groups (dronabinol 71%, ondansetron 64%, combination therapy 53%) when compared with placebo (15%; P < .05 vs. placebo for all). Occurrence rates for nausea intensity and vomiting/retching episodes were the lowest in patients treated with dronabinol, suggesting that dronabinol compares favorably with ondansetron in this situation where a substance P inhibitor would currently be the drug of choice.

Jump up ^ Russo, E. B.; Jiang, H.-E.; Li, X.; Sutton, A.; Carboni, A.; Del Bianco, F.; Mandolino, G.; Potter, D. J.; Zhao, Y.-X.; Bera, S.; Zhang, Y.-B.; Lü, E.-G.; Ferguson, D. K.; Hueber, F.; Zhao, L.-C.; Liu, C.-J.; Wang, Y.-F.; Li, C.-S. (2008). "Phytochemical and genetic analyses of ancient cannabis from Central Asia". Journal of Experimental Botany. 59 (15): 4171–82. doi:10.1093/jxb/ern260. PMC 2639026. PMID 19036842.
If you haven’t been bombarded with CBD marketing or raves about it from friends, get ready. This extract—which comes from either marijuana or its industrial cousin, hemp—is popping up everywhere. There are CBD capsules, tinctures, and liquids for vaping plus CBD-infused lotions, beauty products, snacks, coffee, and even vaginal suppositories. Already some 1,000 brands of CBD products are available in stores—and online in states that don’t have lenient cannabis laws. This is a tiny fraction of what’s to come: The CBD market is poised to exceed $1 billion by 2020, per the Chicago-based research firm Brightfield Group.
Fatty Acids. The quality of an oil or fat is most importantly determined by its fatty acid composition. Hemp is of high nutritional quality because it contains high amounts of unsaturated fatty acids, mostly oleic acid (C18:1, 10%–16%), linoleic acid (C18:2, 50%–60%), alpha-linolenic acid (C18:3, 20%–25%), and gamma-linolenic acid (C18:3, 2%–5%) (Fig. 37). Linoleic acid and alpha-linolenic acid are the only two fatty acids that must be ingested and are considered essential to human health (Callaway 1998). In contrast to shorter-chain and more saturated fatty acids, these essential fatty acids do not serve as energy sources, but as raw materials for cell structure and as precursors for biosynthesis for many of the body’s regulatory biochemicals. The essential fatty acids are available in other oils, particularly fish and flaxseed, but these tend to have unpleasant flavors compared to the mellow, slightly nutty flavor of hempseed oil. While the value of unsaturated fats is generally appreciated, it is much less well known that the North American diet is serious nutritionally unbalanced by an excess of linoleic over alpha-linonenic acid. In hempseed, linoleic and alpha-linolenic occur in a ratio of about 3:1, considered optimal in healthy human adipose tissue, and apparently unique among common plant oils (Deferne and Pate 1996). Gamma-linolenic acid or GLA is another significant component of hemp oil (1%–6%, depending on cultivar). GLA is a widely consumed supplement known to affect vital metabolic roles in humans, ranging from control of inflammation and vascular tone to initiation of contractions during childbirth. GLA has been found to alleviate psoriasis, atopic eczema, and mastalgia, and may also benefit cardiovascular, psychiatric, and immunological disorders. Ageing and pathology (diabetes, hypertension, etc.) may impair GLA metabolism, making supplementation desirable. As much as 15% of the human population may benefit from addition of GLA to their diet. At present, GLA is available in health food shops and pharmacies primarily as soft gelatin capsules of borage or evening primrose oil, but hemp is almost certainly a much more economic source. Although the content of GLA in the seeds is lower, hemp is far easier to cultivate and higher-yielding. It is important to note that hemp is the only current natural food source of GLA, i.e. not requiring the consumption of extracted dietary supplements. There are other fatty acids in small concentrations in hemp seed that have some dietary significance, including stearidonic acid (Callaway et al. 1996) and eicosenoic acid (Mölleken and Theimer 1997). Because of the extremely desirable fatty acid constitution of hemp oil, it is now being marketed as a dietary supplement in capsule form (Fig. 38).

No, as long as the plant is used correctly then no it’s not a bad thing. I’m sure there’s probably more good capability about that plant that people know or don’t know. No matter how it’s administered, as long as used properly it’s a good thing. It probably has more healing capabilities than people know about and since big Pharma or whoever it is out there discovered this, that’s probably why they made it illegal for all we know. Yes, I know there’s no money in cure which would hurt big Pharma but oh well! If they want to keep us away from the cure and keep us all sick, I say go for it anyway and go for the cure.
As of March 2016, more than half of the 50 states have laws that allow for some hemp production, according to this chart. Yet, many states, such as California, where Jungmaven is based, will only allow for industrial hemp cultivation when federal law coincides with state law. That is, when Congress passes a bill permitting industrial hemp across the US. Currently, Jungmann imports his hemp from China, but he’s confident Congress will pass the bill legalizing industrial farming of hemp in July.
CDFA's Commercial Feed Regulatory Program (CFRP) is responsible for the enforcement of California state law and regulations pertinent to the manufacturing, distribution and labeling of commercial livestock feed while preventing adulterated feed from being consumed by livestock and poultry. For more information regarding livestock feed, contact CDFA's CFRP.
Another claim is that Mellon, Secretary of the Treasury and the wealthiest man in America at that time, had invested heavily in DuPont's new synthetic fiber, nylon, and believed[dubious – discuss] that the replacement of the traditional resource, hemp, was integral to the new product's success.[121][126][127][128][129][130][131][132] The company DuPont and many industrial historians dispute a link between nylon and hemp, nylon became immediately a scarce commodity.[clarification needed] Nylon had characteristics that could be used for toothbrushes (sold from 1938) and very thin nylon fiber could compete with silk and rayon in various textiles normally not produced from hemp fiber, such as very thin stockings for women.[125][133][134][135][136]
The world-leading producer of hemp is China, which produces more than 70% of the world output. France ranks second with about a quarter of the world production. Smaller production occurs in the rest of Europe, Chile, and North Korea. Over 30 countries produce industrial hemp, including Australia, Austria, Canada, Chile, China, Denmark, Egypt, Finland, Great Britain, Germany, Greece,[64] Hungary, India, Italy, Japan, Korea, Netherlands, New Zealand, Poland, Portugal, Romania, Russia, Slovenia, Spain, Sweden, Switzerland, Thailand, Turkey and Ukraine.[65][66]
I totally agree. The greed of the pharmaceutical with their lobbyist to stop the government from making it a schedule III drug so much more research can be done. They do not care about the people, just money. We the people must rise up and let our government know, we care more about our friends and family than the money they give, to you congress men/women and senators get, and we VOTE. The only power we have is writing or calling congress men/women and senators, huge rallies and each and every ones VOTE. They would rather stay in office, than even receive big monies from big pharm for their campaigns. VOTES will win over.

A 2015 meta analysis found that, although a longer period of abstinence was associated with smaller magnitudes of impairment, both retrospective and prospective memory were impaired in cannabis users. The authors concluded that some, but not all, of the deficits associated with cannabis use were reversible.[114] A 2012 meta analyses found that deficits in most domains of cognition persisted beyond the acute period of intoxication, but was not evident in studies where subjects were abstinent for more than 25 days.[115] Few high quality studies have been performed on the long-term effects of cannabis on cognition, and results were generally inconsistent.[116] Furthermore, effect sizes of significant findings were generally small.[115] One review concluded that, although most cognitive faculties were unimpaired by cannabis use, residual deficits occurred in executive functions.[117] Impairments in executive functioning are most consistently found in older populations, which may reflect heavier cannabis exposure, or developmental effects associated with adolescent cannabis use.[118] One review found three prospective cohort studies that examined the relationship between self reported cannabis use and intelligence quotient (IQ). The study following the largest number of heavy cannabis users reported that IQ declined between ages 7–13 and age 38. Poorer school performance and increased incidence of leaving school early were both associated with cannabis use, although a causal relationship was not established.[110] Cannabis users demonstrated increased activity in task-related brain regions, consistent with reduced processing efficiency.[119]
Former House Speaker John Boehner (R-OH) is the latest public official to endorse significant marijuana law reforms after leaving office. “Over the last 10 or 15 years, the American people’s attitudes have changed dramatically,” he told Bloomberg. “I find myself in that same position.” Boehner, along with former Massachusetts Gov. Bill Weld (R), is joining … Continue reading Former GOP House Speaker Backs Marijuana Descheduling, Joins Cannabiz
As the demand for CBD products has increased, some states have started to take action. Over the past two years, 17 states have passed “CBD-only” laws, assuring parents who purchase CBD oil to treat their sick children that they won’t face arrest or prosecution from state law enforcement for possessing what the federal government still considers a Schedule I narcotic.
In the 1970s, President Nixon declared a “War on Drugs” and signed into law the Controlled Substances Act of 1970. This law established a set of banned drugs and created the Drug Enforcement Administration (DEA). It also unintentionally outlawed one of the world’s oldest domesticated crop, hemp. This not only led to the demise of hemp, but also an increased misconception of the plant.
It is not surprising that male-associated markers are relatively abundant. In dioecious plants where sex chromosomes have not been identified, markers for maleness indicate either the presence of sex chromosomes which have not been distinguished by cytological methods or that the marker is tightly linked to a gene involved in sex determination.[14]
In the United Kingdom, cultivation licences are issued by the Home Office under the Misuse of Drugs Act 1971. When grown for nondrug purposes, hemp is referred to as industrial hemp, and a common product is fibre for use in a wide variety of products, as well as the seed for nutritional aspects and for the oil. Feral hemp or ditch weed is usually a naturalized fibre or oilseed strain of Cannabis that has escaped from cultivation and is self-seeding.[86]
A rather thorough analysis of the scope of the illicit marijuana industry in Canada for 1998 is reported at www.rcmp-grc.gc.ca/html/drugsituation.htm#Marihuana and summarized in MacLeod (1999). At least 800 tonnes (t) of marijuana were grown in Canada in 1998, representing a harvest of 4.7 million flowering plants. More than 50% of the marijuana available in Canada is grown domestically. An average mature plant was estimated to produce 170 g of “marketable substance.” The value of the Canadian crop is uncertain, but has been estimated to be in the billions of dollars annually (Heading 1998; MacLeod 1999).
The dosages mentioned do not take into account the strength of the tincture. I have Elixinol 300, I took 1/2 dropper (0.5ml, which offers 5mg of CBD) as indicated on the bottle and felt severely nauseous for 3 hours thereafter. There is no way I cold take this dose twice per day, as recommended on the bottle. The high dosages on this site must surely be for much weaker concentrations?
CBD vaporizer oils can be used in a vaporizer of your choice. They offer a healthy way of inhaling your daily dose of the CBD supplement. Vaping is a very direct way of ingesting CBD oil. When you vape, the CBD enters the lungs and goes directly into the bloodstream, completely bypassing the digestive system. This method allows for greater bioavailability.
Marijuana is the most common illegal drug reported in motor vehicle accidents.[75] A 2012 meta-analysis found that cannabis use was associated with an increased risk of being involved in a motor vehicle crash.[76] A 2016 review also found a statistically significant increase in crash risk associated with marijuana use, but noted that this risk was "of low to medium magnitude."[77] The increase in risk of motor vehicle crash for cannabis use is between 2 and 3 times relative to baseline, whereas that for comparable doses of alcohol is between 6 and 15 times.[78]
Short-term use of the drug impairs thinking and coordination. In long-term studies, teens who smoke marijuana have lower IQs later on, as well as structural differences in their brains, though scientists debate whether this is an effect of the drug or a result of habitual pot smokers seeking out less intellectually stimulating pursuits. A 2016 study on almost 300 students by the University of Montreal published in the journal Development and Psychopathology found that teens who start smoking around age 14 do worse on some cognitive tests by age 20 than non-smokers. They also have a higher school dropout rate. If they wait until age 17 to start, though, the smokers do not seem to have the same impairments, according to the study. 
Cannabis use generally makes psychotic symptoms worse and lowers the person’s chances of recovery from a psychotic episode. People with a psychotic illness who use drugs experience more delusions, hallucinations and other symptoms. They have a higher rate of hospitalisation for psychosis, and treatment is generally less effective for them. People with a psychotic illness should not use cannabis.

"CBD increases the circulating levels of your natural endocannabinoids, which, in turn, interact with your cannabinoid receptors," Bonn-Miller says. "CBD has also been shown to interact with serotonin receptors, and that may be part of why it has some beneficial effects on anxiety. It also interacts with some pain receptors, which may be why we're starting to see effects on pain and inflammation."
What makes CBD so appealing is that it’s non-intoxicating, so it won’t get you high, though it “is technically psychoactive, because it can influence things like anxiety,” Jikomes said. Although much of the marketing blitz around CBD centers on the fact that you can take it without getting stoned, there isn’t much research looking at the effects of CBD when used in isolation, with a couple of exceptions. One is the use of CBD to treat seizures: CBD is the active ingredient in the only cannabis product that the Food and Drug Administration has signed off on — a drug called Epidiolex, which is approved for treating two rare forms of epilepsy. Animal models and a few human studies suggest that CBD can help with anxiety, but those are the only conditions with much research on CBD in isolation.
I am currently going through red skin syndrome/topical steroid withdrawal. The only cure as of now is time(6 months to 3 years) and waiting out horrible eczema-like flares. My main issue is burning/tingling skin that is almost constant. Steroids close off blood vessels and when you stop them they 'wake' up causing this nerve discomfort/pain. I've been smoking medical cannabis for the duration of my recovery(1.5 years) and It's done wonders except that the flare is around my mouth and I'm afraid the smoking is causing more issues.. as well as helping. I need to step up my game and take a different approach. I am wondering how to go about using cbd but I don't know where to start and was wondering if you could help. Thank you
Specific city and county laws have been enacted to regulate how citizens and tourists may possess and consume marijuana. Penalties exist for driving while under the influence of marijuana. Someone driving under the influence of marijuana is considered impaired in both Colorado and Washington when five nanograms per milliliter (ng/mL) of blood or more of active THC is detected.
Although cannabis as a drug and industrial hemp both derive from the species Cannabis sativa and contain the psychoactive component tetrahydrocannabinol (THC), they are distinct strains with unique phytochemical compositions and uses.[6] Hemp has lower concentrations of THC and higher concentrations of cannabidiol (CBD), which decreases or eliminates its psychoactive effects.[6] The legality of industrial hemp varies widely between countries. Some governments regulate the concentration of THC and permit only hemp that is bred with an especially low THC content.[7][8]
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