According to Delphic analysis by British researchers in 2007, cannabis has a lower risk factor for dependence compared to both nicotine and alcohol. However, everyday use of cannabis may be correlated with psychological withdrawal symptoms, such as irritability or insomnia, and susceptibility to a panic attack may increase as levels of THC metabolites rise. However, cannabis withdrawal symptoms are typically mild and are never life-threatening.
Neuropathic pain is a symptom cancer patients may experience, especially if treated with platinum-based chemotherapy or taxanes. Two RCTs of inhaled Cannabis in patients with peripheral neuropathy or neuropathic pain of various etiologies found that pain was reduced in patients who received inhaled Cannabis, compared with those who received placebo.[58,59] Two additional trials of inhaled Cannabis have also demonstrated the benefit of Cannabis over placebo in HIV-associated neuropathic pain.[60,61]
A 2016 review of animal studies indicated that cannabidiol has potential as an anxiolytic for relief of anxiety-related disorders and fear. Reviews of preliminary research showed cannabidiol has potential for improving addictive disorders and drug dependence, although as of 2016, they indicated limited high-quality evidence for anti-addictive effects in people.
Hemp, Canabis sativa is a plant originally from central Asia. It was cultivated with, and sometimes in place of flax because the stem fibers are similar. By the seventeenth century, Russia, Latvia, and other countries around the Baltic Sea were the major producers of hemp. It was from these areas Britain obtained its supply. However, during periods of military hostilities, the English had trouble acquiring enough hemp.
This is a huge, HUGE step for N.C. First of all farmers can FINALLY make money off land that has grown tobacco for generations. FINALLY doubter I finding out there are many uses for the plant. Perhaps one of the biggest things is the impact on the environment. Most products, if not all, are biodegradable. Also, a huge factor is that in the field of medicine. Will this lead to medical and/or recreational marijuana? Time will tell. As for me, I quit smoking it 20 years ago. I do, however, believe any and all forms of cannabis should and will be made legal. Legal, if for no other reason, so we can stop making people who smoke it into criminals, filling up our jails and prisons. This will free up police, etc.. to finding real criminals. Last, but defiantly not least, IMHO, there is the N.C. aspect. That being I thought we would never, EVER see this time in N.C. Even if it is just industrial hemp for now, it’s a start. Who knows, in the not too distant future, legislatures and law enforcement will become open minded enough to legalize all forms of cannabis, HOPEFULLY. With the youth of these times moving into the right fields, and of course us boomers weighing in, it won’t be too long. AMEN
Canadian experience with growing hemp commercially for the last 4 years has convinced many growers that it is better to use a single-purpose cultivar, seed or fiber, than a dual-purpose cultivar. The recent focus of Canadian hemp breeders has been to develop cultivars with high seed yields, low stature (to avoid channeling the plants’ energy into stalk, as is the case in fiber cultivars), early maturation (for the short growing seasons of Canada), and desirable fatty acid spectrum (especially gamma-linolenic acid).
As with a fermented food like kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants. Changes in the weather, soil, and water can all impact the biology of the source material. While we verify Certificates of Analysis (and take many other criteria into consideration during our review process), even the most reputable five-star companies have no way to control for every variable in this organic process.
The plant is also known as hemp, although this term is often used to refer only to varieties of Cannabis cultivated for non-drug use. Cannabis has long been used for hemp fibre, for hemp oils, for medicinal purposes, and as a recreational drug. Industrial hemp products are made from cannabis plants selected to produce an abundance of fiber. To satisfy the UN Narcotics Convention, some cannabis strains have been bred to produce minimal levels of tetrahydrocannabinol (THC), the principal psychoactive constituent. Some strains have been selectively bred to produce a maximum of THC (a cannabinoid), the strength of which is enhanced by curing the flowers. Various compounds, including hashish and hash oil, are extracted from the plant.
Most pro-hemp initiatives in the United States are now focused on defining and distinguishing between industrial hemp and marijuana. Some pro-hemp supporters would like to move the control of U.S. hemp production from the DEA to the USDA. Proponents of legalizing hemp also argue that new technology to distinguish THC levels both in the field and from the air will allow for adequate production enforcement.
Thank you for sharing your story. It is amazing the stories I have heard and the things you here the politicians debating over. The truth is out. They need to get over there guilty pride and pharmaceutical needs to be slapped down a few pegs. This is happening we just need to defend the corporations that back the oil, the pharma, any other corporation that doesn’t fight a health and balance model.
Some studies state that while there is no proof for the gateway hypothesis, young cannabis users should still be considered as a risk group for intervention programs. Other findings indicate that hard drug users are likely to be poly-drug users, and that interventions must address the use of multiple drugs instead of a single hard drug. Almost two-thirds of the poly drug users in the "2009/10 Scottish Crime and Justice Survey" used cannabis.
After fighting the effects of thyroid cancerfor 12 years I wanted to die. Every day. Now, please understand that these were thoughts with no actions, I was just miserable in pain.After 1 week on the CBD oil, (5 drops under the toungue 2x per day) I am a different woman. I now have hope. Some of my emotional pain is presenting as physical pain, but IT'S LEAVING MY BODY.
One of the most curious uses of hemp is as a fence to prevent pollen transfer in commercial production of seeds. Isolation distances for ensuring that seeds produced are pure are considerable for many plants, and often impractical. At one point in the 1980s, the only permitted use of hemp in Germany was as a fence or hedge to prevent plots of beets being used for seed production from being contaminated by pollen from ruderal beets. The high and rather inpenetrable hedge that hemp can produce was considered unsurpassed by any other species for the purpose. As well, the sticky leaves of hemp were thought to trap pollen. However, Saeglitz et al. (2000) demonstrated that the spread of beet pollen is not effectively prevented by hemp hedges. Fiber (i.e. tall) cultivars of hemp were also once used in Europe as wind-breaks, protecting vulnerable crops against wind damage. Although hemp plants can lodge, on the whole very tall hemp is remarkably resistant against wind.
CBD may also enhance uptake of cytotoxic drugs into malignant cells. Activation of the transient receptor potential vanilloid type 2 (TRPV2) has been shown to inhibit proliferation of human glioblastoma multiforme cells and overcome resistance to the chemotherapy agent carmustine.  One study showed that coadministration of THC and CBD over single-agent usage had greater antiproliferative activity in an in vitro study with multiple human glioblastoma multiforme cell lines. In an in vitro model, CBD increased TRPV2 activation and increased uptake of cytotoxic drugs, leading to apoptosis of glioma cells without affecting normal human astrocytes. This suggests that coadministration of CBD with cytotoxic agents may increase drug uptake and potentiate cell death in human glioma cells. Also, CBD together with THC may enhance the antitumor activity of classic chemotherapeutic drugs such as temozolomide in some mouse models of cancer.[13,33] A meta-analysis of 34 in vitro and in vivo studies of cannabinoids in glioma reported that all but one study confirmed that cannabinoids selectively kill tumor cells.
George Washington also imported the Indian Hemp plant from Asia, which was used for fiber and, by some growers, for intoxicating resin production. In a letter to William Pearce who managed the plants for him Washington says, "What was done with the Indian Hemp plant from last summer? It ought, all of it, to be sown again; that not only a stock of seed sufficient for my own purposes might have been raised, but to have disseminated seed to others; as it is more valuable than common hemp."
Preliminary research indicates that cannabidiol may reduce adverse effects of THC, particularly those causing intoxication and sedation, but only at high doses. Safety studies of cannabidiol showed it is well-tolerated, but may cause tiredness, diarrhea, or changes in appetite as common adverse effects. Epidiolex documentation lists sleepiness, insomnia and poor quality sleep, decreased appetite, diarrhea, and fatigue.
As detailed below, the development of hemp as a new legal crop in North America must be considered in relation to illicit cultivation, so it is important to appreciate the scope of the drug situation. Up until the first half of the 20th century, drug preparations of Cannabis were used predominantly as a recreational inebriant in poor countries and the lower socio-economic classes of developed nations. After World War II, marijuana became associated with the rise of a hedonistic, psychedelic ethos, first in the United States and eventually over much of the world, with the consequent development of a huge international illicit market that exceeds the value of the hemp market during its heyday. Table 3 shows the “economic significance” (dollars generated in the black market plus dollar cost of control measures) of the illicit drug industry associated with C. sativa, and contrasts this with the estimated dollar value of major categories of legitimate uses. In the Netherlands, the annual value of narcotic hemp cultivation (ca. $10 billion) exceeds the value of tulips (Collins 1999). Marijuana has become the most widely disseminated illicit species in the world (Schultes and Hofmann 1980). With the exception of alcohol, it is the most widely used recreational euphoric drug. About 25% of North Americans are believed to have used Cannabis illegally. According to the US National Institute on Drug Abuse (www.nida.nih.gov/Infofax/marijuana.html), more than 72 million Americans (33%) 12 years of age and older have tried marijuana. Cultivation, commerce, and consumption of drug preparations of Cannabis have been proscribed in most countries during the present century. The cost of enforcing the laws against Cannabis in North America is in the billions of dollars annually. In addition, there are substantial social costs, such as adverse effects on users, particularly those who are convicted. Tragically this includes some legitimate farmers who, faced with financial ruin because of the unprofitability of crops being grown, converted to growing marijuana.
In recent decades, the neurobiology of cannabinoids has been analyzed.[12-15] The first cannabinoid receptor, CB1, was identified in the brain in 1988. A second cannabinoid receptor, CB2, was identified in 1993. The highest expression of CB2 receptors is located on B lymphocytes and natural killer cells, suggesting a possible role in immunity. Endogenous cannabinoids (endocannabinoids) have been identified and appear to have a role in pain modulation, control of movement, feeding behavior, mood, bone growth, inflammation, neuroprotection, and memory.