There have been ten clinical trials on the use of inhaled Cannabis in cancer patients that can be divided into two groups. In one group, four small studies assessed antiemetic activity but each explored a different patient population and chemotherapy regimen. One study demonstrated no effect, the second study showed a positive effect versus placebo, the report of the third study did not provide enough information to characterize the overall outcome as positive or neutral. Consequently, there are insufficient data to provide an overall level of evidence assessment for the use of Cannabis for chemotherapy-induced N/V. Apparently, there are no published controlled clinical trials on the use of inhaled Cannabis for other cancer-related or cancer treatment–related symptoms.
Marijuana is the most common illegal drug reported in motor vehicle accidents.[75] A 2012 meta-analysis found that cannabis use was associated with an increased risk of being involved in a motor vehicle crash.[76] A 2016 review also found a statistically significant increase in crash risk associated with marijuana use, but noted that this risk was "of low to medium magnitude."[77] The increase in risk of motor vehicle crash for cannabis use is between 2 and 3 times relative to baseline, whereas that for comparable doses of alcohol is between 6 and 15 times.[78]
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During the period from 1937 to the late 60s, the U.S. government understood and acknowledged that industrial hemp and marijuana were distinct varieties of the Cannabis plant. Hemp was no longer officially recognized as distinct from marijuana after the passage of the Controlled Substances Act (CSA) of 1970. This is despite the fact that a specific exemption for hemp was included in the CSA under the definition of marijuana. The recent federal court case HIA vs DEA has re-established acknowledgement of distinct varieties of Cannabis, and supports the exemption for non-viable seed and fiber and any products made from them.
A CNN program that featured Charlotte's Web cannabis in 2013 brought increased attention to the use of CBD in the treatment of seizure disorders.[68][69] Since then, 16 states have passed laws to allow the use of CBD products with a doctor's recommendation (instead of a prescription) for treatment of certain medical conditions.[70] This is in addition to the 30 states that have passed comprehensive medical cannabis laws, which allow for the use of cannabis products with no restrictions on THC content.[70] Of these 30 states, eight have legalized the use and sale of cannabis products without requirement for a doctor's recommendation.[70]
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The downsides of graphene are its dwindling sources and costly process to mine and import from rural areas in China and India. Hemp, however, can be grown in almost any terrain or country, and produces hemp bast, the key material used to replace graphene, as a waste byproduct of hemp processing. According to Mitlin’s research, hemp processing is 1,000 times cheaper than graphene processing.
In the 1990s, European firms introduced lines of hemp oil-based personal care products, including soaps, shampoos, bubble baths, and perfumes. Hemp oil is now marketed throughout the world in a range of body care products, including creams, lotions, moisturizers, and lip balms. In Germany, a laundry detergent manufactured entirely from hemp oil has been marketed. Hemp-based cosmetics and personal care products account for about half of the world market for hemp oil (de Guzman 2001).

A randomized, placebo-controlled, crossover pilot study of nabiximols in 16 patients with chemotherapy-induced neuropathic pain showed no significant difference between the treatment and placebo groups. A responder analysis, however, demonstrated that five patients reported a reduction in their pain of at least 2 points on an 11-point scale, suggesting that a larger follow-up study may be warranted.[55]
Medical marijuana refers to the use of the Cannabis plant as a physician-recommended herbal therapy as well as synthetic[181] THC and cannabinoids. So far, the medical use of cannabis is legal only in a limited number of territories, including Canada,[37] Belgium, Australia, the Netherlands, Spain, and many U.S. states. This usage generally requires a prescription, and distribution is usually done within a framework defined by local laws. There is evidence supporting the use of cannabis or its derivatives in the treatment of chemotherapy-induced nausea and vomiting, neuropathic pain, and multiple sclerosis. Lower levels of evidence support its use for AIDS wasting syndrome, epilepsy, rheumatoid arthritis, and glaucoma.[74]
Newer antiemetics (e.g., 5-HT3 receptor antagonists) have not been directly compared with Cannabis or cannabinoids in cancer patients. However, the Cannabis-extract oromucosal spray, nabiximols, formulated with 1:1 THC:CBD was shown in a small pilot randomized, placebo-controlled, double-blinded clinical trial in Spain to treat chemotherapy-related N/V.[39][Level of evidence: 1iC] ASCO antiemetic guidelines updated in 2017 states that evidence remains insufficient to recommend medical marijuana for either the prevention or treatment of N/V in patients with cancer who receive chemotherapy or radiation therapy.[30]
Marijuana regulators in Washington State will entertain sweeping changes to how marijuana is tested, processed, packaged and sold in one of the U.S.’s oldest recreational marijuana markets, officials announced late Wednesday. Recreational cannabis has been sold in regulated retail outlets in Washington since 2014. Consumers there pay one of the country’s highest tax burdens, generating … Continue reading Washington State Prepares To Rewrite Marijuana Testing And Packaging Rules
As noted above, hemp seed cake makes an excellent feed for animals. However, feeding entire plants is another matter, because the leaves are covered with the resin-producing glands. While deer, groundhogs, rabbits, and other mammals will nibble on hemp plants, mammals generally do not choose to eat hemp. Jain and Arora (1988) fed narcotic Cannabis refuse to cattle, and found that the animals “suffered variable degrees of depression and revealed incoordination in movement.” By contrast, Letniak et al. (2000) conducted an experimental trial of hemp as silage. No significant differences were found between yield of the hemp and of barley/oat silage fed to heifers, suggesting that fermenting hemp plants reduces possible harmful constituents.
Jump up ^ Russo, E. B.; Jiang, H.-E.; Li, X.; Sutton, A.; Carboni, A.; Del Bianco, F.; Mandolino, G.; Potter, D. J.; Zhao, Y.-X.; Bera, S.; Zhang, Y.-B.; Lü, E.-G.; Ferguson, D. K.; Hueber, F.; Zhao, L.-C.; Liu, C.-J.; Wang, Y.-F.; Li, C.-S. (2008). "Phytochemical and genetic analyses of ancient cannabis from Central Asia". Journal of Experimental Botany. 59 (15): 4171–82. doi:10.1093/jxb/ern260. PMC 2639026. PMID 19036842.

Locsta....I share your pain of degenerative and bulging disk disease, along with fibromyalgia, chronic fatigue and arthritis. Absolutely no energy and chronic pain all day, every day. I'm curious as to what type and brand of the CBD oil you are taking and for how long have you been using it? I've been researching CBD oil for months and am quite confused!


Karl W. Hillig, a graduate student in the laboratory of long-time Cannabis researcher Paul G. Mahlberg[77] at Indiana University, conducted a systematic investigation of genetic, morphological, and chemotaxonomic variation among 157 Cannabis accessions of known geographic origin, including fiber, drug, and feral populations. In 2004, Hillig and Mahlberg published a chemotaxonomic analysis of cannabinoid variation in their Cannabis germplasm collection. They used gas chromatography to determine cannabinoid content and to infer allele frequencies of the gene that controls CBD and THC production within the studied populations, and concluded that the patterns of cannabinoid variation support recognition of C. sativa and C. indica as separate species, but not C. ruderalis.[52] The authors assigned fiber/seed landraces and feral populations from Europe, Central Asia, and Turkey to C. sativa. Narrow-leaflet and wide-leaflet drug accessions, southern and eastern Asian hemp accessions, and feral Himalayan populations were assigned to C. indica. In 2005, Hillig published a genetic analysis of the same set of accessions (this paper was the first in the series, but was delayed in publication), and proposed a three-species classification, recognizing C. sativa, C. indica, and (tentatively) C. ruderalis.[55] In his doctoral dissertation published the same year, Hillig stated that principal components analysis of phenotypic (morphological) traits failed to differentiate the putative species, but that canonical variates analysis resulted in a high degree of discrimination of the putative species and infraspecific taxa.[78] Another paper in the series on chemotaxonomic variation in the terpenoid content of the essential oil of Cannabis revealed that several wide-leaflet drug strains in the collection had relatively high levels of certain sesquiterpene alcohols, including guaiol and isomers of eudesmol, that set them apart from the other putative taxa.[79] Hillig concluded that the patterns of genetic, morphological, and chemotaxonomic variation support recognition of C. sativa and C. indica as separate species. He also concluded there is little support to treat C. ruderalis as a separate species from C. sativa at this time, but more research on wild and weedy populations is needed because they were underrepresented in their collection.
The confusion compounds when one realizes that in today’s popular lexicon, the terms indica, sativa, and hybrid tend to indicate a set of effects, rather than the taxonomy of a particular strain. But that’s just as well. Most marijuana strains today, especially those under commercial cultivation, are genetic hybrids. Only a handful of pure, or “landrace” cannabis strains are in circulation.
It was the seizures that tipped Penny off that something wasn’t right with Harper after she and her husband Dustin brought her home from the hospital as a newborn. Several months later, having tried a battery of epilepsy medications and still without a diagnosis, Penny and Dustin flew to Boston with Harper to see an expert in infant seizures. It was there they first heard of CDKL5. “This is the point where life changed significantly,” Penny said, “because now we had this diagnosis. You know, this abnormality in our family that we cannot fix.”
For many, the medical and therapeutic potential of cannabis is what makes legalizing the marijuana plant such an important political and social task. Federal prohibition has established barriers to comprehensive cannabis research in the United States. However, researchers in other countries continue to make significant contributions to our knowledge of the cannabis plant and how it affects the human body.
My mom is late stage dementia. We have tried coconut oil/black pepper/curcumin combo for years. Gives only tine bit of help, and is not something that reverses dementia. Maybe in someone who can score better than a 14 on the mme it could be of help. But cannabinoid is a different story. Cannabinoids produce better results in less time. Can't say yet that they will reverse anything though.

While cultivating marijuana’s non-intoxicating cousin is currently illegal in the U.S. outside of exceptions for state-approved hemp research programs authorized under the 2014 Farm Bill, there’s a strong possibility that industrial hemp will be broadly legalized—possibly by the end of the year—once the House and Senate reconcile their versions of a new Farm Bill and put it on the president’s desk.
Fibres are obtained by subjecting the stalks to a series of operations—including retting, drying, and crushing—and a shaking process that completes separation from the woody portion, releasing the long, fairly straight fibre, or line. The fibre strands, usually over 1.8 metres (5.8 feet) long, are made of individual cylindrical cells with an irregular surface. The fibre, longer and less flexible than flax, is usually yellowish, greenish, or a dark brown or gray and, because it is not easily bleached to sufficiently light shades, is rarely dyed. It is strong and durable and is used for cordage—e.g., twine, yarn, rope, cable, and string—and for artificial sponges and such coarse fabrics as sacking (burlap) and canvas. In Italy some hemp receives special processing, producing whitish colour and attractive lustre, and is used to make fabric similar to linen.
The woody core (hurds, sometimes called shives) of hemp makes remarkably good animal bedding (Fig. 28, 29). The hurds are sometimes molded into small pellets for bedding applications (Fig. 30). Such appears to be unsurpassed for horse bedding, and also make an excellent litter for cats and other pets (Fig. 31). The hurds can absorb up to five times their weight in moisture (typically 50% higher than wood shavings), do not produce dust (following initial dust removal), and are easily composted. Hemp bedding is especially suited to horses allergic to straw. In Europe, the animal bedding market is not considered important (Karus et al. 2000), but in North America there are insufficient hemp hurds available to meet market demand.
Several studies have demonstrated the therapeutic effects of cannabinoids for nausea and vomiting in the advanced stages of illnesses such as cancer and AIDS. Dronabinol (tetrahydrocannabinol) has been available by prescription for more than a decade in the USA. Other therapeutic uses of cannabinoids are being demonstrated by controlled studies, including treatment of asthma and glaucoma, as an antidepressant, appetite stimulant, anticonvulsant and anti-spasmodic, research in this area should continue. For example, more basic research on the central and peripheral mechanisms of the effects of cannabinoids on gastrointestinal function may improve the ability to alleviate nausea and emesis. More research is needed on the basic neuropharmacology of THC and other cannabinoids so that better therapeutic agents can be found.
While cultivating marijuana’s non-intoxicating cousin is currently illegal in the U.S. outside of exceptions for state-approved hemp research programs authorized under the 2014 Farm Bill, there’s a strong possibility that industrial hemp will be broadly legalized—possibly by the end of the year—once the House and Senate reconcile their versions of a new Farm Bill and put it on the president’s desk.
Hemp, grown under license mostly in Canada, is the most publicized “new” crop in North America. Until very recently the prohibition against drug forms of the plant prevented consideration of cultivation of fiber and oilseed cultivars in Canada. However, in the last 10 years three key developments occurred: (1) much-publicized recent advances in the legal cultivation of hemp in western Europe, especially for new value-added products; (2) enterprising farmers and farm groups became convinced of the agricultural potential of hemp in Canada, and obtained permits to conduct experimental cultivation; and (3) lobby groups convinced the government of Canada that narcotic forms of the hemp plant are distinct and distinguishable from fiber and oilseed forms. In March 1998, new regulations (under the Controlled Drugs and Substances Act) were provided to allow the commercial development of a hemp industry in Canada, and since then more than a thousand licenses have been issued. Hectares licensed for cultivation for 1998–2001 were respectively, 2,500, 14,200, 5,487, and 1,355, the decreasing trend due to a glut of seed produced in 1999 and pessimism over new potential regulations barring exports to the US. Information on the commercial potential of hemp in Canada is in Blade (1998), Marcus (1998), and Pinfold Consulting (1998). In the US, a substantial trade in hemp products has developed, based on imports of hemp fiber, grain, and oil. The American agricultural community has observed this, and has had success at the state level in persuading legislators of the advisability of experimental hemp cultivation as a means of evaluating the wisdom of re-establishing American hemp production. However, because of opposition by the federal government, to date there has only been a small experimental plot in Hawaii. Information on the commercial potential of hemp in the US is presented in the following.
The 113th Congress made significant changes to U.S. policies regarding industrial hemp during the omnibus farm bill debate. The Agricultural Act of 2014 (P.L. 113-79) provided that certain research institutions and state departments of agriculture may grow industrial hemp, as part of an agricultural pilot program, if allowed under state laws where the institution or state department of agriculture is located. The FY2015 appropriations (P.L. 113-235) further blocked federal law enforcement authorities from interfering with state agencies, growers, and agricultural research. (From "Hemp as an agricultural commodity," Congressional Research Service)
The most widespread claim for environmental friendliness of hemp is that it has the potential to save trees that otherwise would be harvested for production of lumber and pulp. Earlier, the limitations of hemp as a pulp substitute were examined. With respect to wood products, several factors appear to favor increased use of wood substitutes, especially agricultural fibers such as hemp. Deforestation, particularly the destruction of old growth forests, and the world’s decreasing supply of wild timber resources are today major ecological concerns. Agroforestry using tree species is one useful response, but nevertheless sacrifices wild lands and biodiversity, and is less preferable than sustainable wildland forestry. The use of agricultural residues (e.g. straw bales in house construction) is an especially environmentally friendly solution to sparing trees, but material limitations restrict use. Another chief advantage of several annual fiber crops over forestry crops is relative productivity, annual fiber crops sometimes producing of the order of four times as much per unit of land. Still another important advantage is the precise control over production quantities and schedule that is possible with annual crops. In many parts of the world, tree crops are simply not a viable alternative. “By the turn of the century 3 billion people may live in areas where wood is cut faster than it grows or where fuelwood is extremely scarce” (World Commission on Environment and Development 1987). “Since mid-century, lumber use has tripled, paper use has increased six-fold, and firewood use has soared as Third World populations have multiplied” (Brown et al. 1998). Insofar as hemp reduces the need to harvest trees for building materials or other products, its use as a wood substitute will tend to contribute to preserving biodiversity. Hemp may also enhance forestry management by responding to short-term fiber demand while trees reach their ideal maturation. In developing countries where fuelwood is becoming increasingly scarce and food security is a concern, the introduction of a dual-purpose crop such as hemp to meet food, shelter, and fuel needs may contribute significantly to preserving biodiversity.
Concrete-like blocks made with hemp and lime have been used as an insulating material for construction. Such blocks are not strong enough to be used for structural elements; they must be supported by a brick, wood, or steel frame.[25] However, hemp fibres are extremely strong and durable, and have been shown to be usable as a replacement for wood for many jobs, including creating very durable and breathable homes. The most common use of hemp lime in building is by casting the hemp and lime mix while wet around a timber frame with temporary shuttering, and tamping the mix to form a firm mass; after the removal of the temporary shuttering, the solidified hemp mix is then ready to be plastered with a lime plaster.[26]
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