CBD interacts with the body through the endogenous cannabinoid system (ECS) or endocannabinoid system. First discovered in the late 1980’s, the endocannabinoid system regulates the body’s homeostasis, or general state of balance, impacting such functions as mood, sleep, appetite, hormone regulation, and pain and immune response. Like an acrobat on a highwire, as the environment around us impacts our normal balance, the endocannabinoid system “corrects” by mediating our body’s reaction to keep us level.

Cannabis has an ancient history of ritual use and is found in pharmacological cults around the world. Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices like eating by the Scythians occurred during the 5th to 2nd century BC, confirming previous historical reports by Herodotus.[190] It was used by Muslims in various Sufi orders as early as the Mamluk period, for example by the Qalandars.[191] Smoking pipes uncovered in Ethiopia and carbon-dated to around c. AD 1320 were found to have traces of cannabis.[192]
From the 1950s to the 1980s, the Soviet Union was the world's largest producer of hemp (3,000 km2 in 1970). The main production areas were in Ukraine,[82] the Kursk and Orel regions of Russia, and near the Polish border. Since its inception in 1931, the Hemp Breeding Department at the Institute of Bast Crops in Hlukhiv (Glukhov), Ukraine, has been one of the world's largest centers for developing new hemp varieties, focusing on improving fiber quality, per-hectare yields, and low THC content.[83][84]

As detailed below, the development of hemp as a new legal crop in North America must be considered in relation to illicit cultivation, so it is important to appreciate the scope of the drug situation. Up until the first half of the 20th century, drug preparations of Cannabis were used predominantly as a recreational inebriant in poor countries and the lower socio-economic classes of developed nations. After World War II, marijuana became associated with the rise of a hedonistic, psychedelic ethos, first in the United States and eventually over much of the world, with the consequent development of a huge international illicit market that exceeds the value of the hemp market during its heyday. Table 3 shows the “economic significance” (dollars generated in the black market plus dollar cost of control measures) of the illicit drug industry associated with C. sativa, and contrasts this with the estimated dollar value of major categories of legitimate uses. In the Netherlands, the annual value of narcotic hemp cultivation (ca. $10 billion) exceeds the value of tulips (Collins 1999). Marijuana has become the most widely disseminated illicit species in the world (Schultes and Hofmann 1980). With the exception of alcohol, it is the most widely used recreational euphoric drug. About 25% of North Americans are believed to have used Cannabis illegally. According to the US National Institute on Drug Abuse (www.nida.nih.gov/Infofax/marijuana.html), more than 72 million Americans (33%) 12 years of age and older have tried marijuana. Cultivation, commerce, and consumption of drug preparations of Cannabis have been proscribed in most countries during the present century. The cost of enforcing the laws against Cannabis in North America is in the billions of dollars annually. In addition, there are substantial social costs, such as adverse effects on users, particularly those who are convicted. Tragically this includes some legitimate farmers who, faced with financial ruin because of the unprofitability of crops being grown, converted to growing marijuana.

My mom is late stage dementia. We have tried coconut oil/black pepper/curcumin combo for years. Gives only tine bit of help, and is not something that reverses dementia. Maybe in someone who can score better than a 14 on the mme it could be of help. But cannabinoid is a different story. Cannabinoids produce better results in less time. Can't say yet that they will reverse anything though.
As noted above, hemp seed cake makes an excellent feed for animals. However, feeding entire plants is another matter, because the leaves are covered with the resin-producing glands. While deer, groundhogs, rabbits, and other mammals will nibble on hemp plants, mammals generally do not choose to eat hemp. Jain and Arora (1988) fed narcotic Cannabis refuse to cattle, and found that the animals “suffered variable degrees of depression and revealed incoordination in movement.” By contrast, Letniak et al. (2000) conducted an experimental trial of hemp as silage. No significant differences were found between yield of the hemp and of barley/oat silage fed to heifers, suggesting that fermenting hemp plants reduces possible harmful constituents.
Hemp is considered by a 1998 study in Environmental Economics to be environmentally friendly due to a decrease of land use and other environmental impacts, indicating a possible decrease of ecological footprint in a US context compared to typical benchmarks.[59] A 2010 study, however, that compared the production of paper specifically from hemp and eucalyptus concluded that "industrial hemp presents higher environmental impacts than eucalyptus paper"; however, the article also highlights that "there is scope for improving industrial hemp paper production".[60] Hemp is also claimed to require few pesticides and no herbicides, and it has been called a carbon negative raw material.[61][62] Results indicate that high yield of hemp may require high total nutrient levels (field plus fertilizer nutrients) similar to a high yielding wheat crop.[63]

Understanding the mechanism of cannabinoid-induced analgesia has been increased through the study of cannabinoid receptors, endocannabinoids, and synthetic agonists and antagonists. Cannabinoids produce analgesia through supraspinal, spinal, and peripheral modes of action, acting on both ascending and descending pain pathways.[41] The CB1 receptor is found in both the central nervous system (CNS) and in peripheral nerve terminals. Similar to opioid receptors, increased levels of the CB1 receptor are found in regions of the brain that regulate nociceptive processing.[42] CB2 receptors, located predominantly in peripheral tissue, exist at very low levels in the CNS. With the development of receptor-specific antagonists, additional information about the roles of the receptors and endogenous cannabinoids in the modulation of pain has been obtained.[43,44]
Preliminary research indicates that cannabidiol may reduce adverse effects of THC, particularly those causing intoxication and sedation, but only at high doses.[26] Safety studies of cannabidiol showed it is well-tolerated, but may cause tiredness, diarrhea, or changes in appetite as common adverse effects.[27] Epidiolex documentation lists sleepiness, insomnia and poor quality sleep, decreased appetite, diarrhea, and fatigue.[3]

Hemp jewelry is the product of knotting hemp twine through the practice of macramé. Hemp jewellery includes bracelets, necklaces, anklets, rings, watches and other adornments. Some jewellery features beads made from crystals, glass, stone, wood and bones. The hemp twine varies in thickness and comes in a variety of colors. There are many different stitches used to create hemp jewellery, however, the half knot and full knot stitches are most common.
Since then, many different types of sex determination systems have been discovered, particularly in plants.[14] Dioecy is relatively uncommon in the plant kingdom, and a very low percentage of dioecious plant species have been determined to use the XY system. In most cases where the XY system is found it is believed to have evolved recently and independently.[30]

Jump up ^ Datwyler, SL; Weiblen, GD (2006). "Genetic Variation in Hemp and marijuana (Cannabis sativa L.) sativa plants are taller and less dense. Indica plants are shorter but a lot more dense than sativas. According to Amplified Fragment Length Polymorphisms". Journal of Forensic Sciences. 51 (2): 371–375. doi:10.1111/j.1556-4029.2006.00061.x. PMID 16566773.
The main difference between the two is in its chemical composition, specifically in tetrahydrocannabinol (THC). THC is the chemical responsible marijuana’s psychological effects.An average batch of marijuana contains anywhere from 5-20% THC content. Some premium marijuana can have up to 25-30% THC. Hemp, on the other hand, has a max THC level of 0.3%, essentially making it impossible to feel any psychoactive effect or get a “high”. This threshold is heavily regulated in other countries that have legalized hemp.Hemp also has high cannabidiol (CBD) content that acts as THC’s antagonist, essentially making the minimal amount of THC useless.
CBD may also enhance uptake of cytotoxic drugs into malignant cells. Activation of the transient receptor potential vanilloid type 2 (TRPV2) has been shown to inhibit proliferation of human glioblastoma multiforme cells and overcome resistance to the chemotherapy agent carmustine. [31] One study showed that coadministration of THC and CBD over single-agent usage had greater antiproliferative activity in an in vitro study with multiple human glioblastoma multiforme cell lines.[32] In an in vitro model, CBD increased TRPV2 activation and increased uptake of cytotoxic drugs, leading to apoptosis of glioma cells without affecting normal human astrocytes. This suggests that coadministration of CBD with cytotoxic agents may increase drug uptake and potentiate cell death in human glioma cells. Also, CBD together with THC may enhance the antitumor activity of classic chemotherapeutic drugs such as temozolomide in some mouse models of cancer.[13,33] A meta-analysis of 34 in vitro and in vivo studies of cannabinoids in glioma reported that all but one study confirmed that cannabinoids selectively kill tumor cells.[34]
In Japan, hemp was historically used as paper and a fiber crop. There is archaeological evidence cannabis was used for clothing and the seeds were eaten in Japan back to the Jōmon period (10,000 to 300 BC). Many Kimono designs portray hemp, or asa (Japanese: 麻), as a beautiful plant. In 1948, marijuana was restricted as a narcotic drug. The ban on marijuana imposed by the United States authorities was alien to Japanese culture, as the drug had never been widely used in Japan before. Though these laws against marijuana are some of the world's strictest, allowing five years imprisonment for possession of the drug, they exempt hemp growers, whose crop is used to make robes for Buddhist monks and loincloths for Sumo wrestlers. Because marijuana use in Japan has doubled in the past decade, these exemptions have recently been called into question.[143]
In late 2017, researchers with the University of Guelph in Canada published the first-ever study to document the ideal growing conditions for cannabis. Using liquid organic fertilizer with a PKN ratio of 1.3P–1.7K-4.0N, the experiment tested five increasing rates of fertilization. They also tested two coir-based soil-less growing media, or “substrates.”
Support for legalization has steadily grown over the last several years. Today, medical marijuana is legal in 23 states and the District of Columbia. And even federal officials have begun to soften their stances. Last fall, outgoing Attorney General Eric Holder signaled his support for removing marijuana from the list of Schedule I narcotics. “I think it’s certainly a question we need to ask ourselves, whether or not marijuana is as serious of a drug as heroin,” Holder said. This summer, Chuck Rosenberg, the acting administrator of the U.S. Drug Enforcement Administration, acknowledged that marijuana is not as dangerous as other Schedule I drugs and announced his agents would not be prioritizing marijuana enforcement. Still, as long as marijuana remains illegal under federal law, the haphazard system in which it is studied, produced, and distributed will remain, and Americans will not be able to take full advantage of its medicinal properties.
Jungmann and Thomas aren’t the only ones relying on China for their hemp supply. Today, Patagonia carries about two dozen products in hemp. Most are mixed with other materials, namely organic cotton. Jill Dumain, director of environmental strategy at Patagonia, developed the first hemp supply chain for the outdoor brand in the 1990s. She recalls trying to find suppliers of hemp fabrics in the US and getting frustrated because most of these suppliers were more interested in legalizing marijuana, rather than industrial hemp for fashion. When she requested cost estimates for fabric, she would get price sheets for puny quantities: five to 10 yards.
Cannabis can be prepared into various foods generally called ‘edibles’. It takes between 1-3 hours to feel the effects after eating cannabis.2 Impatient or naïve users may believe they have not taken enough to feel the effects, and if they consume more they may find later that the psychoactive effects are unpleasantly strong. When edible products have inconsistent levels of THC even experienced users may find it difficult to regulate the amount consumed.
Today, dozens of companies produce CBD in an array of forms. CBD can be inhaled through vape pens, applied in topical salves, ingested in edibles, or swallowed in oil-based tinctures. Oil has become the dominant CBD delivery method for kids with epilepsy, since it is easy to administer and ingest, and there is no shortage of it available for sale online. There are dozens of companies boasting names like Healthy Hemp Oil, Dose of Nature, and Natural Organic Solutions, each of them selling CBD products at prices ranging from trivial to dizzyingly steep. You don’t have to look hard to find them. If you have a PayPal account and $100 to spare, you could have a vial of hemp oil delivered to your doorstep.

Although cannabis as a drug and industrial hemp both derive from the species Cannabis sativa and contain the psychoactive component tetrahydrocannabinol (THC), they are distinct strains with unique phytochemical compositions and uses.[6] Hemp has lower concentrations of THC and higher concentrations of cannabidiol (CBD), which decreases or eliminates its psychoactive effects.[6] The legality of industrial hemp varies widely between countries. Some governments regulate the concentration of THC and permit only hemp that is bred with an especially low THC content.[7][8]

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