Despite its centrality in human cultures across the globe, the European taxonomists who bequeathed Cannabis sativa its name didn’t quite get it right. When Carolus Linneaus came to naming the marijuana plant’s genus, he thought there was only one species, instead of the three we now know exist. Hence the confusion surrounding the fact that there are three distinct species of the genus Cannabis sativa, one of which is the sativa species.
One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors. During this 2-year study, groups of mice and rats were given various doses of THC by gavage. A dose-related decrease in the incidence of hepatic adenoma tumors and hepatocellular carcinoma (HCC) was observed in the mice. Decreased incidences of benign tumors (polyps and adenomas) in other organs (mammary gland, uterus, pituitary, testis, and pancreas) were also noted in the rats. In another study, delta-9-THC, delta-8-THC, and cannabinol were found to inhibit the growth of Lewis lung adenocarcinoma cells in vitro and in vivo . In addition, other tumors have been shown to be sensitive to cannabinoid-induced growth inhibition.[5-8]
On the federal level, several bills currently before Congress seek to change the way the government treats CBD. One such bill, the Compassionate Access Act, would exclude CBD from the classification of “marijuana” and remove both from the DEA’s list of Schedule I controlled substances. Rescheduling CBD in such a way would make research and cultivation of CBD much easier.
As noted above, hemp seed cake makes an excellent feed for animals. However, feeding entire plants is another matter, because the leaves are covered with the resin-producing glands. While deer, groundhogs, rabbits, and other mammals will nibble on hemp plants, mammals generally do not choose to eat hemp. Jain and Arora (1988) fed narcotic Cannabis refuse to cattle, and found that the animals “suffered variable degrees of depression and revealed incoordination in movement.” By contrast, Letniak et al. (2000) conducted an experimental trial of hemp as silage. No significant differences were found between yield of the hemp and of barley/oat silage fed to heifers, suggesting that fermenting hemp plants reduces possible harmful constituents.
Jump up ^ Russo, E. B.; Jiang, H.-E.; Li, X.; Sutton, A.; Carboni, A.; Del Bianco, F.; Mandolino, G.; Potter, D. J.; Zhao, Y.-X.; Bera, S.; Zhang, Y.-B.; Lü, E.-G.; Ferguson, D. K.; Hueber, F.; Zhao, L.-C.; Liu, C.-J.; Wang, Y.-F.; Li, C.-S. (2008). "Phytochemical and genetic analyses of ancient cannabis from Central Asia". Journal of Experimental Botany. 59 (15): 4171–82. doi:10.1093/jxb/ern260. PMC 2639026. PMID 19036842.
In recent decades, the neurobiology of cannabinoids has been analyzed.[12-15] The first cannabinoid receptor, CB1, was identified in the brain in 1988. A second cannabinoid receptor, CB2, was identified in 1993. The highest expression of CB2 receptors is located on B lymphocytes and natural killer cells, suggesting a possible role in immunity. Endogenous cannabinoids (endocannabinoids) have been identified and appear to have a role in pain modulation, control of movement, feeding behavior, mood, bone growth, inflammation, neuroprotection, and memory.
From the 1950s to the 1980s, the Soviet Union was the world's largest producer of hemp (3,000 km2 in 1970). The main production areas were in Ukraine, the Kursk and Orel regions of Russia, and near the Polish border. Since its inception in 1931, the Hemp Breeding Department at the Institute of Bast Crops in Hlukhiv (Glukhov), Ukraine, has been one of the world's largest centers for developing new hemp varieties, focusing on improving fiber quality, per-hectare yields, and low THC content.
Cannabidiol is insoluble in water but soluble in organic solvents such as pentane. At room temperature, it is a colorless crystalline solid. In strongly basic media and the presence of air, it is oxidized to a quinone. Under acidic conditions it cyclizes to THC. The synthesis of cannabidiol has been accomplished by several research groups.
Hernandez said interactions between FDA-approved pharmaceuticals and CBD oils are a serious concern. “What we’ve found so far is that [CBD] can actually affect the levels of some of your epilepsy medications,” Hernandez told me. The diarrhea and vomiting associated with CBD oil ingestion can lower the levels of other drugs in patients’ bloodstreams, while the way the body absorbs CBD can raise the levels of certain medications.
There are ways to strain dangerous contaminants out of raw hemp paste. And most companies stand behind their quality and safety procedures. “We continuously test all our products ... to ensure our consumers get the levels of natural constituents they expect from the quality hemp stalk oil they purchase,” HempMedsPx states on its web site. “Additionally, all our products are tested for safety, to ensure there are no solvents, heavy metals, or other potentially harmful materials in our oil. Because we take these steps, we are always confident in our products, and you can be too.”
In his office, however, Hernandez was wary of the CBD boom. He advises well-meaning parents to think twice about voyaging into the world of over-the-counter hemp oil treatments, even if their circumstances are dire. “It’s a huge gimmick that a lot of companies are using,” Hernandez said. “You don’t know what you’re getting. ... There’s a major quality problem.”
Cannabis use generally makes psychotic symptoms worse and lowers the person’s chances of recovery from a psychotic episode. People with a psychotic illness who use drugs experience more delusions, hallucinations and other symptoms. They have a higher rate of hospitalisation for psychosis, and treatment is generally less effective for them. People with a psychotic illness should not use cannabis.
For patients suffering from seizures, the legalization of cannabis would be a decisive turning point. Epilepsy makes you desperate. Seizures are painful, sometimes debilitating. And then there are the aftershocks: broken teeth, bruises and cuts, lost time, humiliation. People with epilepsy are often depressed, and have more than double the suicide rate of the population at large. Epilepsy is also associated with a syndrome known as Sudden Unexpected Death in Epilepsy, wherein a previously healthy person with epilepsy simply dies without warning or explanation. Grinding on without relief isn’t an option, but getting help is enormously expensive. Research conducted by Charles Begley, a professor of public health at the University of Texas, found that epilepsy treatment costs between $8,500 and $11,000 per year. Real Scientific Hemp Oil is no less expensive than its pharmaceutical counterparts, with no assistance from insurance. A single three-gram vial costs $149, while a six-pack of 10-gram tubes can cost $1,999 (or $1,599 on sale). HempMedsPx suggests a “serving size” of 0.5 ml twice daily. Only when these drugs are recognized as such will insurance pick up the tab.
The objectivity of scientific evaluation of the medicinal value of marijuana to date has been questioned. In the words of Hirst et al. (1998): “The ...status of cannabis has made modern clinical research almost impossible. This is primarily because of the legal, ethical and bureaucratic difficulties in conducting trials with patients. Additionally, the general attitude towards cannabis, in which it is seen only as a drug of abuse and addiction, has not helped.” In a recent editorial, the respected journal Nature (2001) stated: “Governments, including the US federal government, have until recently refused to sanction the medical use of marijuana, and have also done what they can to prevent its clinical testing. They have defended their inaction by claiming that either step would signal to the public a softening of the so-called ‘war on drugs.’... The pharmacology of cannabinoids is a valid field of scientific investigation. Pharmacologists have the tools and the methodologies to realize its considerable potential, provided the political climate permits them to do so.” Given these current demands for research on medicinal marijuana, it will be necessary to produce crops of drug types of C. sativa.
Taking CBD oil is like drinking milk and calling it calcium, Hernandez said: There’s some in there, but at very low concentrations dispersed among a host of other ingredients. And what those other ingredients are is anyone’s guess. “The thing to know is that CBD hasn’t gone through the safety controls, the efficacy controls that we usually use, the clinical trials,” Hernandez said. “The jury is still out regarding how safe this drug is.”
Synthetic cannabis is illegal in New Zealand. It is designed to imitate the effects of cannabis and is usually dried plant material sprayed with chemicals known as synthetic cannabinoids. It is also available in liquid form. Little is known about the chemicals used in synthetic cannabis and the effects can be unpredictable, especially when mixed with other substances.
Probably indigenous to temperate Asia, C. sativa is the most widely cited example of a “camp follower.” It was pre-adapted to thrive in the manured soils around man’s early settlements, which quickly led to its domestication (Schultes 1970). Hemp was harvested by the Chinese 8500 years ago (Schultes and Hofmann 1980). For most of its history, C. sativa was most valued as a fiber source, considerably less so as an intoxicant, and only to a limited extent as an oilseed crop. Hemp is one of the oldest sources of textile fiber, with extant remains of hempen cloth trailing back 6 millennia. Hemp grown for fiber was introduced to western Asia and Egypt, and subsequently to Europe somewhere between 1000 and 2000 BCE. Cultivation in Europe became widespread after 500 ce. The crop was first brought to South America in 1545, in Chile, and to North America in Port Royal, Acadia in 1606. The hemp industry flourished in Kentucky, Missouri, and Illinois between 1840 and 1860 because of the strong demand for sailcloth and cordage (Ehrensing 1998). From the end of the Civil War until 1912, virtually all hemp in the US was produced in Kentucky. During World War I, some hemp cultivation occurred in several states, including Kentucky, Wisconsin, California, North Dakota, South Dakota, Minnesota, Indiana, Illinois, Ohio, Michigan, Kansas, and Iowa (Ehrensing 1998). The second world war led to a brief revival of hemp cultivation in the Midwest, as well as in Canada, because the war cut off supplies of fiber (substantial renewed cultivation also occurred in Germany for the same reason). Until the beginning of the 19th century, hemp was the leading cordage fiber. Until the middle of the 19th century, hemp rivaled flax as the chief textile fiber of vegetable origin, and indeed was described as “the king of fiber-bearing plants,—the standard by which all other fibers are measured” (Boyce 1900). Nevertheless, the Marihuana Tax Act applied in 1938 essentially ended hemp production in the United States, although a small hemp fiber industry continued in Wisconsin until 1958. Similarly in 1938 the cultivation of Cannabis became illegal in Canada under the Opium and Narcotics Act.
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According to DSM-V criteria, 9% of those who are exposed to cannabis develop cannabis use disorder, compared to 20% for cocaine, 23% for alcohol and 68% for nicotine. Cannabis abuse disorder in the DSM-V involves a combination of DSM-IV criteria for cannabis abuse and dependence, plus the addition of craving, minus the criterion related to legal troubles.
I can’t disagree more with attacking “Big Pharma” or Trump with regards to fixing this problem! Screw the political affiliations for now, let’s change the whole Schedule 1 nightmare. We’re steeped in technology and we have insanely archaic drug laws. Worse, our gov then pressures the countries we give money to (which is all of them) to follow suit by adopting our effed up way. Schedule 1 needs to be dismantled. The research can’t be done on anything listed with very few exceptions. There’s other Sched.1 drugs that need to be available for research by legitimate people, there’s lots of exciting research in psychedelics that’s stalled by archaic laws. That part might just require big pharma to help.
The high lipid-solubility of cannabinoids results in their persisting in the body for long periods of time. Even after a single administration of THC, detectable levels of THC can be found in the body for weeks or longer (depending on the amount administered and the sensitivity of the assessment method). A number of investigators have suggested that this is an important factor in marijuana's effects, perhaps because cannabinoids may accumulate in the body, particularly in the lipid membranes of neurons.
Professors William Emboden, Loran Anderson, and Harvard botanist Richard E. Schultes and coworkers also conducted taxonomic studies of Cannabis in the 1970s, and concluded that stable morphological differences exist that support recognition of at least three species, C. sativa, C. indica, and C. ruderalis. For Schultes, this was a reversal of his previous interpretation that Cannabis is monotypic, with only a single species. According to Schultes' and Anderson's descriptions, C. sativa is tall and laxly branched with relatively narrow leaflets, C. indica is shorter, conical in shape, and has relatively wide leaflets, and C. ruderalis is short, branchless, and grows wild in Central Asia. This taxonomic interpretation was embraced by Cannabis aficionados who commonly distinguish narrow-leafed "sativa" strains from wide-leafed "indica" strains.
Fig. 11. Frequency histograms of THC concentration in germplasm collections. Left, collection of E. Small and D. Marcus; of the 167 accessions, 43% had THC levels >0.3%. Right, the collection of the Vavilov Institute, St. Petersburg; of the 278 accessions for which chemical analyses were reported in Anonymous (1975), about 55% had THC levels >0.3%.
In Western Europe, the cultivation of hemp was not legally banned by the 1930s, but the commercial cultivation stopped by then, due to decreased demand compared to increasingly popular artificial fibers. Speculation about the potential for commercial cultivation of hemp in large quantities has been criticized due to successful competition from other fibers for many products. The world production of hemp fiber fell from over 300,000 metric tons 1961 to about 75,000 metric tons in the early 1990s and has after that been stable at that level.
Cannabis can be prepared into various foods generally called ‘edibles’. It takes between 1-3 hours to feel the effects after eating cannabis.2 Impatient or naïve users may believe they have not taken enough to feel the effects, and if they consume more they may find later that the psychoactive effects are unpleasantly strong. When edible products have inconsistent levels of THC even experienced users may find it difficult to regulate the amount consumed.
There is also considerable potential for other industries using hemp in the manner that the automobile industry has demonstrated is feasible. Of course, all other types of transportation vehicles from bicycles to airplanes might make use of such technology. Natural fibers have considerable advantages for use in conveyance (Karus et al. 2000): low density and weight reduction, favorable mechanical, acoustical, and processing properties (including low wear on tools), no splintering in accidents, occupational health benefits (compared to glass fibers), no off-gassing of toxic compounds, and price advantages. Additional types of composite using hemp in combination with other natural fibers, post-industrial plastics or other types of resins, are being used to produce non-woven matting for padding, sound insulation, and other applications.
Hemp seeds contain virtually no THC, but THC contamination results from contact of the seeds with the resin secreted by the epidermal glands on the leaves and floral parts, and also by the failure to sift away all of the bracts (which have the highest concentration of THC of any parts of the plant) that cover the seeds. This results in small levels of THC appearing in hempseed oil and foods made with the seeds. Although most of the western hemp-growing world uses 0.3% THC as a maximum concentration for authorized cultivation of hemp plants, regulations in various countries allow only a much lower level of THC in human food products manufactured from the seeds. Currently, up to 10 ppm THC is permitted in seeds and oil products used for food purposes in Canada. In Germany, more stringent limits were set for food in 2000: 5 ppm in food oil, 0.005 ppm in beverages, and 0.15 ppm in all other foods. The US Drug Enforcement Administration published new regulations on hemp in the Federal Register on October 9th 2001 that in effect 4 months later would ban the food use of hemp in the US because any amount of THC would be unacceptable in foods (follow links at www.hempreport.com/). These proposals are currently being challenged by the hemp industry. Limits have been set because of concerns about possible toxicity and interference with drug tests (Grotenhermen et al. 1998). An extensive analysis of literature dealing with the toxicity of hemp is in Orr and Starodub (1999; see Geiwitz 2001 for an analysis). Because hemp food products are considered to have great economic potential, there is considerable pressure on the hemp industry in North America to reduce THC levels.
I strongly agree they really are greedy and money hungry. Isn’t it always funny how the big ones fall sooner or later? The government can’t have everything, there are just some things that belong to the people. Medicine plants in general have been around since the start of creation, and it looks like we’re just finding out which ones they are. Our forefathers know which ones they were and they knew how to use them but it’s been a forgotten skill some generations have forgotten since modern medicine took over. That’s not right. I saw some articles where the government was going to try to once again outlaw hemp and cannabis. I say if you really want some before it’s outlawed, grab up as much as you can and hide it somewhere good where no one but you can ever find it. I would highly recommend putting it in an airtight container with as many other airtight layers around it as possible. That way, it will never be found by anyone who’s not supposed to find it. The best advantage is to have enough handy to take care of yourself for life while everyone not in on ditching big Pharma is dying. If hamper and cannabis are outlawed, only the elite will be the ones still standing in the end
The cultivation of hemp in the EU is heavily weighted toward fiber production over oilseed production. In 1999, the EU produced about 27,000 t of hemp fiber, but only about 6,200 t of hemp seeds, mostly in France, and 90% of this was used as animal feed (Karus et al. 2000). The seeds (Fig. 33) have traditionally been employed as bird and poultry feed, but feeding the entire seeds to livestock has been considered to be a poor investment because of the high cost involved (although subsidization in Europe allows such usage, especially in France where hemp seeds are not legally permitted in human food). As pointed out later, higher yield and better harvesting practices may make whole hempseed an economical livestock feed. Moreover, seed cake left after expressing the oil is an excellent feed. Efforts are underway in Europe to add value in the form of processed products for hemp, especially cosmetics and food but, as noted below, the North American market is already quite advanced in oilseed applications.
The public meeting will be held via telephone conference. Access to the conference call can be made at http://go.ncsu.edu/industrialhemp or by calling 1-408-638-0986 (U.S. toll) or 1-646-876-9923 (U.S. toll). The meeting ID is 840-748-948 . Participants will be prompted to enter their name and email address to enter the meeting via the website, or prompted for a unique participant ID for the call. They should press # to access the call.
Jump up ^ McLaren JA, Silins E, Hutchinson D, Mattick RP, Hall W (January 2010). "Assessing evidence for a causal link between cannabis and psychosis: a review of cohort studies". The International Journal on Drug Policy. 21 (1): 10–9. doi:10.1016/j.drugpo.2009.09.001. PMID 19783132. The contentious issue of whether cannabis use can cause serious psychotic disorders that would not otherwise have occurred cannot be answered based on the existing data
In 1937, the Marijuana Tax Act strictly regulated the cultivation and sale of all cannabis varieties. The Controlled Substances Act of 1970 classified all forms of cannabis — including hemp — as a Schedule I drug, making it illegal to grow it in the United States (which is why we’re forced to import hemp from other countries as long as it contains scant levels of THC — 0.3% is the regulation for hemp cultivation in the European Union and Canada). As a result of this long-term prohibition, most people have forgotten the industrial uses of the plant and continue to misidentify hemp with its cannabis cousin, marijuana.
According to the United States Department of Health and Human Services, there were 455,000 emergency room visits associated with cannabis use in 2011. These statistics include visits in which the patient was treated for a condition induced by or related to recent cannabis use. The drug use must be "implicated" in the emergency department visit, but does not need to be the direct cause of the visit. Most of the illicit drug emergency room visits involved multiple drugs. In 129,000 cases, cannabis was the only implicated drug.
So true. Hearst and Rockefeller did not want Hemp or any form of Cannabis interfering with their lucrative paper, pharmaceutical and oil industries. Hemp is versatile and renewable. It can be used for food, medicine, fuel, paper, clothing, plastic, building materials; just about anything paper and oil is used for. These bastard wealthy people have done a disservice to all people and for the sake of lining their already copiously rich pockets. They and those like them are criminals of the worst order
Scott Shannon, M.D., assistant clinical professor at the University of Colorado, recently sifted through patient charts from his four-doctor practice to document CBD’s effects on anxiety. His study, as yet unpublished, found “a fairly rapid decrease in anxiety scores that appears to persist for months,” he says. But he says he can’t discount a placebo effect, especially since “there’s a lot of hype right now.”
Cannabis is indigenous to Central Asia and Indian subcontinent, and its use for fabric and rope dates back to the Neolithic age in China and Japan. It is unclear when cannabis first became known for its psychoactive properties; some scholars suggest that the ancient Indian drug soma, mentioned in the Vedas, was cannabis, although this theory is disputed.
Cooper recently got funding from the National Institutes of Health for a study looking at cannabinoids — including CBD in isolation — as a substitute for opioids, and numerous other clinical trials of CBD are underway. It will be several years before results are available, but these studies should help clarify both what benefits the substance may provide and any side effects it may come with. Most of the adverse effects so far associated with cannabis, such as impairments in short-term memory, coordination and judgment,2 come from products that contain THC as well as CBD, Cooper said, but we need to do more studies to find out for sure whether CBD has fewer risks. Studies are also needed to identify the best way to administer and dose CBD. “I get emails from people asking me what dose of CBD to use, and the truth is, we really don’t know,” Cooper said.
Hemp fiber has been used extensively throughout history, with production climaxing soon after being introduced to the New World. For centuries, items ranging from rope, to fabrics, to industrial materials were made from hemp fiber. Hemp was also commonly used to make sail canvas. The word "canvas" is derived from the word cannabis. Pure hemp has a texture similar to linen. Because of its versatility for use in a variety of products, today hemp is used in a number of consumer goods, including clothing, shoes, accessories, dog collars, and home wares.