I have sporadic back spasms for year I see a chiropractor monthly for maintenance (it help) and deal with daily Knee & hip joint pain due to my job (heavy mechanic/steel work with lots of walking). after reading all the great reviews on CBD oil I want to get off the daily ibuprofen regiment and try CBD oil. I would like to try it as a gel cap but would like some advise on dosage size. I also want to know how often I should take the CBD treatments. any and all advise is appreciated
Cannabis has mental and physical effects such as creating a "high" or "stoned" feeling, a general change in perception, heightened mood, and an increase in appetite.[21][22] Onset of effects is within minutes when smoked, and about 30 to 60 minutes when cooked and eaten.[21][23] They last for between two and six hours.[23] Short-term side effects may include a decrease in short-term memory, dry mouth, impaired motor skills, red eyes, and feelings of paranoia or anxiety.[21][24][25] Long-term side effects may include addiction, decreased mental ability in those who started as teenagers, and behavioral problems in children whose mothers used cannabis during pregnancy.[21] Studies have found a strong relation between cannabis use and the risk of psychosis,[26] though the cause-and-effect relationship is debated.[27]
Indeed, hemp oil products have grown out of a market largely devoid of regulations or safety protocols. The state of the CBD industry harks back to the age of elixirs and potions hawked from covered wagons to the awed denizens of pioneer towns. There are no industrywide standards in place to ensure that CBD oils are consistently formulated batch-to-batch. There is no regulatory body screening products for pesticides, heavy metals, solvent residues, and other dangerous contaminants. The laboratories that companies contract to test their CBD products are themselves neither standardized nor consistently regulated. No medical research exists to recommend how much CBD a patient should take, nor is there detailed, reliable documentation of how CBD interacts with most epilepsy medications.
Another field in which CBD is creating a buzz is in the area of mood disorders like anxiety and depression. Both conditions have been treated with a variety of medications, courtesy of Big Pharma, that have had varying levels of success. Again, the long list of side effects can be off-putting to someone who just wants to get through the day without the sweaty tension of anxiety or the gray haze of depression.
The seeds are sown from mid-April to mid-May with grain drills to 4–6 cm sowing depth. Hemp needs less fertilizer than corn does. A total of 60–150 kg of nitrogen, 40–140 kg phosphorus (P2O5) and 75–200 kg of potassium [5] per acre for hemp fiber made before sowing and again later, maybe three to four weeks. When practiced, especially in France double use of fiber and seed fertilization with nitrogen doses up to 100 kg / ha rather low. Organic fertilizers such as manure can utilize industrial hemp well. Neither weeds nor crop protection measures are necessary.[52]

In short, Cannabidiol – or CBD – is a cannabis compound that has many therapeutic benefits. Usually extracted from the leaves and flowers of hemp plants – though marijuana can also be a source – CBD oil is then incorporated into an array of marketable products. These products vary from the most common, like sublingual oils and topical lotions, to the less common (think CBD lattes). Basically, if you can dream it, you can buy it.

Prescription medicine (Schedule 4) for therapeutic use containing 2 per cent (2.0%) or less of other cannabinoids commonly found in cannabis (such as ∆9-THC). A schedule 4 drug under the SUSMP is Prescription Only Medicine, or Prescription Animal Remedy – Substances, the use or supply of which should be by or on the order of persons permitted by State or Territory legislation to prescribe and should be available from a pharmacist on prescription.[74]

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Short-term use increases both minor and major adverse effects.[103] Common side effects include dizziness, feeling tired, vomiting, and hallucinations.[103] Long-term effects of cannabis are not clear.[105] Concerns including memory and cognition problems, risk of addiction, schizophrenia in young people, and the risk of children taking it by accident.[102]
The most widespread claim for environmental friendliness of hemp is that it has the potential to save trees that otherwise would be harvested for production of lumber and pulp. Earlier, the limitations of hemp as a pulp substitute were examined. With respect to wood products, several factors appear to favor increased use of wood substitutes, especially agricultural fibers such as hemp. Deforestation, particularly the destruction of old growth forests, and the world’s decreasing supply of wild timber resources are today major ecological concerns. Agroforestry using tree species is one useful response, but nevertheless sacrifices wild lands and biodiversity, and is less preferable than sustainable wildland forestry. The use of agricultural residues (e.g. straw bales in house construction) is an especially environmentally friendly solution to sparing trees, but material limitations restrict use. Another chief advantage of several annual fiber crops over forestry crops is relative productivity, annual fiber crops sometimes producing of the order of four times as much per unit of land. Still another important advantage is the precise control over production quantities and schedule that is possible with annual crops. In many parts of the world, tree crops are simply not a viable alternative. “By the turn of the century 3 billion people may live in areas where wood is cut faster than it grows or where fuelwood is extremely scarce” (World Commission on Environment and Development 1987). “Since mid-century, lumber use has tripled, paper use has increased six-fold, and firewood use has soared as Third World populations have multiplied” (Brown et al. 1998). Insofar as hemp reduces the need to harvest trees for building materials or other products, its use as a wood substitute will tend to contribute to preserving biodiversity. Hemp may also enhance forestry management by responding to short-term fiber demand while trees reach their ideal maturation. In developing countries where fuelwood is becoming increasingly scarce and food security is a concern, the introduction of a dual-purpose crop such as hemp to meet food, shelter, and fuel needs may contribute significantly to preserving biodiversity.
CDFA's Commercial Feed Regulatory Program (CFRP) is responsible for the enforcement of California state law and regulations pertinent to the manufacturing, distribution and labeling of commercial livestock feed while preventing adulterated feed from being consumed by livestock and poultry. For more information regarding livestock feed, contact CDFA's CFRP.
Some individuals have been found to have mutations on the CNR1 gene, which is responsible for coding the CB1 receptor (a type of receptor in cells throughout your body that interacts with cannabinoids). Issues with the CNR1 gene can ultimately result in a poorly functioning endocannabinoid system, which is an important variable when figuring out how to use CBD oil.

Cannabinoids may also contribute to pain modulation through an anti-inflammatory mechanism; a CB2 effect with cannabinoids acting on mast cell receptors to attenuate the release of inflammatory agents, such as histamine and serotonin, and on keratinocytes to enhance the release of analgesic opioids has been described.[45-47] One study reported that the efficacy of synthetic CB1- and CB2-receptor agonists were comparable with the efficacy of morphine in a murine model of tumor pain.[48]

In 1972, the Dutch government divided drugs into more- and less-dangerous categories, with cannabis being in the lesser category. Accordingly, possession of 30 grams or less was made a misdemeanor.[202] Cannabis has been available for recreational use in coffee shops since 1976.[203] Cannabis products are only sold openly in certain local "coffeeshops" and possession of up to 5 grams for personal use is decriminalised, however: the police may still confiscate it, which often happens in car checks near the border. Other types of sales and transportation are not permitted, although the general approach toward cannabis was lenient even before official decriminalisation.[204][205][206]
The 2014 Farm Bill included a section to allow for universities and state departments of agriculture to begin cultivating industrial hemp for purposes of research, provided that the growing and cultivating of industrial hemp is allowed under state law. Industrial hemp is defined by SB 263 as all parts and varieties of the plant cannabis sativa L that contain a delta-9 tetrahydrocannabinol (THC) concentration of no more than 0.3 percent on a dry weight basis.

Cannabis sativa is extremely unusual in the diversity of products for which it is or can be cultivated. Popular Mechanics magazine (1938) touted hemp as “the new billion dollar crop,” stating that it “can be used to produce more than 25,000 products, ranging from dynamite to Cellophane.” Table 1 presents the principal products for which the species is cultivated in Europe, all of which happen to be based on fiber. This presentation stresses the products that hold the most promise for North America, which also include a considerable range of oilseed applications (Table 2; Fig. 1).

The endocannabinoid system is believed to be centrally involved in the regulation of mood and the extinction of aversive memories. Animal studies have shown CBD to have anxiolytic properties. It was shown in rats that these anxiolytic properties are mediated through unknown mechanisms.[52] Anxiolytic effects of CBD have been shown in several animal models.[53,54]

No ongoing clinical trials of Cannabis as a treatment for cancer in humans were identified in a PubMed search. The only published trial of any cannabinoid in patients with cancer is a small pilot study of intratumoral injection of delta-9-THC in patients with recurrent glioblastoma multiforme, which demonstrated no significant clinical benefit.[19,20] In a trial (NCT02255292) conducted in Israel, oral cannabidiol (CBD) was investigated as a single salvage agent for recurrent solid tumors. The study was projected to be completed in 2015; however, no results have been published. A small exploratory phase II study (GWCA1208 Part A [NCT01812603]) was conducted in the United Kingdom that used nabiximols, a 1:1 ratio of THC:CBD in a Cannabis-based medicinal extract oromucosal spray, in conjunction with temozolomide in treating patients with recurrent glioblastoma multiforme. The study enrolled 21 patients. Final results have not been published.

According to researchers, 25 percent of all cancer patients use medical marijuana. Cancer patients are finding relief from medical cannabis. And they want to know more about it. Research conducted at St. George’s University of London, found the two most common cannabinoids in marijuana, tetrahydrocannabinol (THC) and cannabidiol (CBD), weakened the ferocity of cancer cells and made them more susceptible to radiation treatment. Other studies have shown that medical marijuana treatments can slow the growth of cancer cells and halt their spread to other parts of the body.
The earliest recorded uses date from the 3rd millennium BC.[32] Since the early 20th century, cannabis has been subject to legal restrictions. The possession, use, and sale of cannabis is illegal in most countries of the world.[33][34] Medical cannabis refers to the physician-recommended use of cannabis, which takes place in Canada, Belgium, Australia, the Netherlands, Germany, Spain, and 31 U.S. states.[35] In September 2018 cannabis was legalized in South Africa[36] while Canada legalized recreational use of cannabis in October 2018.[37]
Traditionally, hemp stalks would be water-retted first before the fibers were beaten off the inner hurd by hand, a process known as scutching. As mechanical technology evolved, separating the fiber from the core was accomplished by crushing rollers and brush rollers that would produce a nearly clean fiber. After the Marijuana Tax Act was implemented in 1938, the technology for separating the fibers from the core remained "frozen in time".
CBD is a 5-HT1A receptor agonist, which may also contribute to an anxiolytic effect.[146] This likely means the high concentrations of CBD found in Cannabis indica mitigate the anxiogenic effect of THC significantly.[146] The cannabis industry claims that sativa strains provide a more stimulating psychoactive high while indica strains are more sedating with a body high.[147] However this is disputed by researchers.[148]
Cannabis, (genus Cannabis), plant belonging to the family Cannabaceae of the nettle order (Urticales). By some classifications, the genus Cannabis comprises a single species, hemp (Cannabis sativa), a stout, aromatic, erect annual herb that originated in Central Asia and is now cultivated worldwide, including in Europe, southern Asia, the Middle East, India, Africa, and the Americas. A tall canelike variety is raised for the production of hemp fibre, while the female plant of a short branchier variety is prized as the more abundant source of the psychoactive substance tetrahydrocannabinol (THC), the active ingredient of marijuana.
As detailed below, the development of hemp as a new legal crop in North America must be considered in relation to illicit cultivation, so it is important to appreciate the scope of the drug situation. Up until the first half of the 20th century, drug preparations of Cannabis were used predominantly as a recreational inebriant in poor countries and the lower socio-economic classes of developed nations. After World War II, marijuana became associated with the rise of a hedonistic, psychedelic ethos, first in the United States and eventually over much of the world, with the consequent development of a huge international illicit market that exceeds the value of the hemp market during its heyday. Table 3 shows the “economic significance” (dollars generated in the black market plus dollar cost of control measures) of the illicit drug industry associated with C. sativa, and contrasts this with the estimated dollar value of major categories of legitimate uses. In the Netherlands, the annual value of narcotic hemp cultivation (ca. $10 billion) exceeds the value of tulips (Collins 1999). Marijuana has become the most widely disseminated illicit species in the world (Schultes and Hofmann 1980). With the exception of alcohol, it is the most widely used recreational euphoric drug. About 25% of North Americans are believed to have used Cannabis illegally. According to the US National Institute on Drug Abuse (www.nida.nih.gov/Infofax/marijuana.html), more than 72 million Americans (33%) 12 years of age and older have tried marijuana. Cultivation, commerce, and consumption of drug preparations of Cannabis have been proscribed in most countries during the present century. The cost of enforcing the laws against Cannabis in North America is in the billions of dollars annually. In addition, there are substantial social costs, such as adverse effects on users, particularly those who are convicted. Tragically this includes some legitimate farmers who, faced with financial ruin because of the unprofitability of crops being grown, converted to growing marijuana.
Low concentrations of CBD aren’t the only concern, either. Cannabis plants are hardy and tough, and their thick stalks possess a special property: bioremediation. When grown in contaminated soil, hemp plants absorb heavy metals and other chemical waste, effectively cleansing the terrain. While all plants absorb some chemicals from the soil, the structure, size, and genetic makeup of hemp make it especially adept at this task. Cannabis is so effective that crops of industrial hemp were planted in the aftermath of the 1986 Chernobyl disaster to help purify heavily irradiated soil. When hemp stalks are used for fiber, paper, and other nonconsumptive industrial purposes, the contaminants absorbed into the plants pose no threat to humans.
Hemp has at times in the past been grown simply for its ornamental value. The short, strongly-branched cultivar ‘Panorama’ (Fig. 43) bred by Iván Bósca, the dean of the world’s living hemp breeders, was commercialized in Hungary in the 1980s, and has been said to be the only ornamental hemp cultivar available. It has had limited success, of course, because there are very few circumstances that permit private gardeners can grow Cannabis as an ornamental today. By contrast, beautiful ornamental cultivars of opium poppy are widely cultivated in home gardens across North America, despite their absolute illegality and the potentially draconian penalties that could be imposed. Doubtless in the unlikely event that it became possible, many would grow hemp as an ornamental.

The challenge to find lighter and longer-lasting energy storage devices (e.g., batteries) can be found in almost every sector. Hemp could prove to revolutionize battery life by aiding in the development of faster, smaller and cheaper supercapacitors. A supercapacitor is an energy storage device that can discharge powerful infusions of energy, needed only in small bursts. Such powerful discharges are used in braking systems of electric vehicles, the powering on of computers and new technologies such as rapid phone charging or cordless tools.
As marijuana is legalized in more and more states, the wellness world has whipped itself into a frenzy over a non-intoxicating cannabis derivative called cannabidiol. CBD products can be found on the internet and in health-food stores, wellness catalogs and even bookstores. (A bookstore in downtown Boulder, Colorado, displays a case of CBD products between the cash register and the stacks of new releases.) Celebrities like Gwyneth Paltrow, disgraced cyclist1 Floyd Landis and former Denver Broncos quarterback Jake Plummer are all touting CBD products, and according to Bon Appétit, CBD-infused lattes have become “the wellness world’s new favorite drink.”
There are thousands of unique varieties of hemp. The cultivars used for CBD oil contain significantly higher concentrations of CBD than others. Using these uniquely potent plants, it is possible to extract cannabis oil that contains significant levels of cannabidiol, as well as essential vitamins, minerals, fatty acids, terpenes, flavonoids, and other non-psychoactive cannabinoids.

THC and its major (inactive) metabolite, THC-COOH, can be measured in blood, urine, hair, oral fluid or sweat using chromatographic techniques as part of a drug use testing program or a forensic investigation of a traffic or other criminal offense.[52] The concentrations obtained from such analyses can often be helpful in distinguishing active use from passive exposure, elapsed time since use, and extent or duration of use. These tests cannot, however, distinguish authorized cannabis smoking for medical purposes from unauthorized recreational smoking.[141] Commercial cannabinoid immunoassays, often employed as the initial screening method when testing physiological specimens for marijuana presence, have different degrees of cross-reactivity with THC and its metabolites.[142] Urine contains predominantly THC-COOH, while hair, oral fluid and sweat contain primarily THC.[52] Blood may contain both substances, with the relative amounts dependent on the recency and extent of usage.[52]
Hemp, grown under license mostly in Canada, is the most publicized “new” crop in North America. Until very recently the prohibition against drug forms of the plant prevented consideration of cultivation of fiber and oilseed cultivars in Canada. However, in the last 10 years three key developments occurred: (1) much-publicized recent advances in the legal cultivation of hemp in western Europe, especially for new value-added products; (2) enterprising farmers and farm groups became convinced of the agricultural potential of hemp in Canada, and obtained permits to conduct experimental cultivation; and (3) lobby groups convinced the government of Canada that narcotic forms of the hemp plant are distinct and distinguishable from fiber and oilseed forms. In March 1998, new regulations (under the Controlled Drugs and Substances Act) were provided to allow the commercial development of a hemp industry in Canada, and since then more than a thousand licenses have been issued. Hectares licensed for cultivation for 1998–2001 were respectively, 2,500, 14,200, 5,487, and 1,355, the decreasing trend due to a glut of seed produced in 1999 and pessimism over new potential regulations barring exports to the US. Information on the commercial potential of hemp in Canada is in Blade (1998), Marcus (1998), and Pinfold Consulting (1998). In the US, a substantial trade in hemp products has developed, based on imports of hemp fiber, grain, and oil. The American agricultural community has observed this, and has had success at the state level in persuading legislators of the advisability of experimental hemp cultivation as a means of evaluating the wisdom of re-establishing American hemp production. However, because of opposition by the federal government, to date there has only been a small experimental plot in Hawaii. Information on the commercial potential of hemp in the US is presented in the following.
"Skunk" refers to several named strains of potent cannabis, grown through selective breeding and sometimes hydroponics. It is a cross-breed of Cannabis sativa and C. indica (although other strains of this mix exist in abundance). Skunk cannabis potency ranges usually from 6% to 15% and rarely as high as 20%. The average THC level in coffee shops in the Netherlands is about 18–19%.[242]
Cannabis is mostly used for recreation or as a medicinal drug, although it may also be used for spiritual purposes. In 2013, between 128 and 232 million people used cannabis (2.7% to 4.9% of the global population between the ages of 15 and 65).[28] It is the most commonly used illegal drug both in the world and the United States.[21][28] The countries with the highest use among adults as of 2018 are Zambia, the United States, Canada, and Nigeria.[29] In 2016, 51% of people in the United States had ever used cannabis.[30] About 12% had used it in the past year, and 7.3% had used it in the past month.[31]
And without high-quality trials, experts don’t know how much is best for a given purpose. The staff at Roth’s dispensary told her, “Try some once or twice a day and see what happens.” (Half a dropper’s worth was a good amount for her.) One thing scientists feel confident about is that CBD is not dangerous. It won’t damage vital organs even at doses as high as 5,000 mg a day, Marcu says, and nobody has died from simply overdosing on a cannabis product.
Several studies have demonstrated the therapeutic effects of cannabinoids for nausea and vomiting in the advanced stages of illnesses such as cancer and AIDS. Dronabinol (tetrahydrocannabinol) has been available by prescription for more than a decade in the USA. Other therapeutic uses of cannabinoids are being demonstrated by controlled studies, including treatment of asthma and glaucoma, as an antidepressant, appetite stimulant, anticonvulsant and anti-spasmodic, research in this area should continue. For example, more basic research on the central and peripheral mechanisms of the effects of cannabinoids on gastrointestinal function may improve the ability to alleviate nausea and emesis. More research is needed on the basic neuropharmacology of THC and other cannabinoids so that better therapeutic agents can be found.

Cannabis was also known to the ancient Assyrians, who discovered its psychoactive properties through the Iranians.[187] Using it in some religious ceremonies, they called it qunubu (meaning "way to produce smoke"), a probable origin of the modern word "cannabis".[188] The Iranians also introduced cannabis to the Scythians, Thracians and Dacians, whose shamans (the kapnobatai—"those who walk on smoke/clouds") burned cannabis flowers to induce trance.[189]
In an in vivo model using severe combined immunodeficient mice, subcutaneous tumors were generated by inoculating the animals with cells from human non-small cell lung carcinoma cell lines.[23] Tumor growth was inhibited by 60% in THC-treated mice compared with vehicle-treated control mice. Tumor specimens revealed that THC had antiangiogenic and antiproliferative effects. However, research with immunocompetent murine tumor models has demonstrated immunosuppression and enhanced tumor growth in mice treated with THC.[24,25]
Some jurisdictions use free voluntary treatment programs and/or mandatory treatment programs for frequent known users. Simple possession can carry long prison terms in some countries, particularly in East Asia, where the sale of cannabis may lead to a sentence of life in prison or even execution. Political parties, non-profit organizations, and causes based on the legalization of medical cannabis and/or legalizing the plant entirely (with some restrictions) have emerged in such countries as China and Thailand.[213][214]
“Folks at the various state Departments of Agriculture are so excited to bring in hemp – excited to introduce any crop, really, and especially to reintroduce this extraordinarily versatile one,” Beckerman said. “But they’re not experts; they’re learning like anybody else. So getting in there, looking at proposed legislation and rules to make sure [proposals] actually make sense for the crop – on an agronomic level, on a regulatory level – and monitoring changes to that legislation, regulation, or industry, is common sense.” She went on,
The opportunity to grow a new specialty oilseed crop in Kansas offers potential for diversification for Kansas farmers looking for an alternative crop, or for new farming enterprises interested in cultivating industrial hemp. The Kansas agriculture industry has developed a statewide strategic growth plan in recent years, and is committed to pursuing new and innovative opportunities to grow agriculture. The research generated by participants of this new industrial hemp program will be valuable data in identifying the growth potential offered in this sector.
Hemp can be used as a "mop crop" to clear impurities out of wastewater, such as sewage effluent, excessive phosphorus from chicken litter, or other unwanted substances or chemicals. Additionally, hemp is being used to clean contaminants at the Chernobyl nuclear disaster site, by way of a process which is known as phytoremediation—the process of clearing radioisotopes and a variety of other toxins from the soil, water, and air.[44]