^ Jump up to: a b Weinstein A, Livny A, Weizman A (2016). "Brain Imaging Studies on the Cognitive, Pharmacological and Neurobiological Effects of Cannabis in Humans: Evidence from Studies of Adult Users". Current Pharmaceutical Design. 22 (42): 6366–6379. doi:10.2174/1381612822666160822151323. PMID 27549374. 1)The studies reviewed so far demonstrated that chronic cannabis use has been associated with a volume reduction of the hippocampus...3)The overall conclusion arising from these studies is that recent cannabis users may experience subtle neurophysiological deficits while performing on working memory tasks, and that they compensate for these deficits by "working harder" by using additional brain regions to meet the demands of the task.

I totally agree. The greed of the pharmaceutical with their lobbyist to stop the government from making it a schedule III drug so much more research can be done. They do not care about the people, just money. We the people must rise up and let our government know, we care more about our friends and family than the money they give, to you congress men/women and senators get, and we VOTE. The only power we have is writing or calling congress men/women and senators, huge rallies and each and every ones VOTE. They would rather stay in office, than even receive big monies from big pharm for their campaigns. VOTES will win over.


Marijuana is the most common illegal drug reported in motor vehicle accidents.[75] A 2012 meta-analysis found that cannabis use was associated with an increased risk of being involved in a motor vehicle crash.[76] A 2016 review also found a statistically significant increase in crash risk associated with marijuana use, but noted that this risk was "of low to medium magnitude."[77] The increase in risk of motor vehicle crash for cannabis use is between 2 and 3 times relative to baseline, whereas that for comparable doses of alcohol is between 6 and 15 times.[78]
Today he sells numerous hemp-made items, from shoes to shirts, as well as a range of hemp-based health and medicinal products. After some productive networking at recent cannabis conventions, he's also in talks with Julian Marley to distribute his products around the country, and hopes to help bring a full-scale hemp festival — codename Hemp Hop — to New Orleans next year.

If you live in a state where CBD is legal for your condition, it’s best to buy it from a state-regulated dispensary. But even there, oversight is uneven. “I feel safe being a cannabis consumer in Colorado, since the state tracks everything from seed to sale, but I didn’t the first few years after cannabis became legal,” when the rules were still taking shape, says Robyn Griggs Lawrence, the Boulder author of The Cannabis Kitchen Cookbook, which features recipes for cannabis edibles.


In the United States, over three million people suffer from epilepsy – 470,000 of those people are children. Epilepsy is a disorder of the brain that causes seizures – of which there are over thirty different kinds, ranging from mild and infrequent to life-threatening. Not surprisingly, people with epilepsy face significant challenges – from the cost of healthcare to work limitations and social isolation.
Despite its designation as having no medicinal use, Cannabis was distributed by the U.S. government to patients on a case-by-case basis under the Compassionate Use Investigational New Drug program established in 1978. Distribution of Cannabis through this program was closed to new patients in 1992.[1-4] Although federal law prohibits the use of Cannabis, Figure 1 below shows the states and territories that have legalized Cannabis use for medical purposes. Additional states have legalized only one ingredient in Cannabis, such as cannabidiol (CBD), and are not included in the map. Some medical marijuana laws are broader than others, and there is state-to-state variation in the types of medical conditions for which treatment is allowed.[7]
Liquid CBD Oil/Tinctures/Extracts: Drops or tinctures should have a “suggested serving size” and the total milligrams of CBD listed on their packaging. From there, you can determine the amount of CBD you would like to ingest. Simply place the correct quantity of drops under your tongue using the dropper and hold the CBD oil in place for a minimum of 60 seconds. The 60 second hold allows for absorption via the blood vessels underneath your tongue – efficiently bypassing first-pass metabolism. Once 60 seconds has passed, swallow the CBD oil.
It’s a truism to state that pain is an inevitable part of life. And it’s true that we all, from time to time, experience pain that is short-lived and treatable. But those who deal with chronic pain know the debilitating, life-sucking reality of this condition. And traditional medications often come with long lists of side effects which can be as debilitating as the pain itself.
A limited number of studies have examined the effects of cannabis smoking on the respiratory system.[85] Chronic heavy marijuana smoking is associated with coughing, production of sputum, wheezing, and other symptoms of chronic bronchitis.[68] The available evidence does not support a causal relationship between cannabis use and chronic obstructive pulmonary disease.[86] Short-term use of cannabis is associated with bronchodilation.[87]
The cultivation of hemp in the EU is heavily weighted toward fiber production over oilseed production. In 1999, the EU produced about 27,000 t of hemp fiber, but only about 6,200 t of hemp seeds, mostly in France, and 90% of this was used as animal feed (Karus et al. 2000). The seeds (Fig. 33) have traditionally been employed as bird and poultry feed, but feeding the entire seeds to livestock has been considered to be a poor investment because of the high cost involved (although subsidization in Europe allows such usage, especially in France where hemp seeds are not legally permitted in human food). As pointed out later, higher yield and better harvesting practices may make whole hempseed an economical livestock feed. Moreover, seed cake left after expressing the oil is an excellent feed. Efforts are underway in Europe to add value in the form of processed products for hemp, especially cosmetics and food but, as noted below, the North American market is already quite advanced in oilseed applications.
Jump up ^ Juliet Eilperin (February 11, 2013), "'Good seed' versus 'evil weed': Hemp activists eye legalization", The Washington Post – via The Japan Times Online, [A] couple of factors — the high taxes the federal government imposed on growing hemp in the late 1930s and again in the early '50s, and then the DEA's interpretation of the 1970 law — made producing hemp nearly impossible. Since the DEA only grants permits in rare instances and demands costly, elaborate security precautions, large-scale hemp growing in the United States is not viable.
That leaves those touting CBD’s effectiveness pointing primarily to research in mice and petri dishes. There, CBD (sometimes combined with small amounts of THC) has shown promise for helping pain, neurological conditions like anxiety and PTSD, and the immune system—and therefore potentially arthritis, diabetes, multiple sclerosis, cancer, and more.
The above uses are based on hemp as a mechanical strengthener of materials. Hemp can also be chemically combined with materials. For example, hemp with gypsum and binding agents may produce light panels that might compete with drywall. Hemp and lime mixtures make a high quality plaster. Hemp hurds are rich in silica (which occurs naturally in sand and flint), and the hurds mixed with lime undergo mineralization, to produce a stone-like material. The technology is most advanced in France (Fig. 26). The mineralized material can be blown or poured into the cavities of walls and in attics as insulation. The foundations, walls, floors, and ceilings of houses have been made using hemp hurds mixed with natural lime and water. Sometimes plaster of Paris (pure gypsum), cement, or sand is added. The resulting material can be poured like concrete, but has a texture vaguely reminiscent of cork—much lighter than cement, and with better heat and sound-insulating properties. An experimental “ceramic tile” made of hemp has recently been produced (Fig. 27).
“Geotextiles” or “agricultural textiles” include (1) ground-retaining, biodegradable matting designed to prevent soil erosion, especially to stabilize new plantings while they develop root systems along steep highway banks to prevent soil slippage (Fig. 32); and (2) ground-covers designed to reduce weeds in planting beds (in the manner of plastic mulch). At present the main materials used are polymeric (polythene, spun-blown polypropylene) and some glass fiber and natural fibers. Both woven and non-woven fibers can be applied to geotextiles; woven and knitted materials are stronger and the open structure may be advantageous (e.g. in allowing plants to grow through), but non-wovens are cheaper and better at suppressing weeds. Flax and hemp fibers exposed to water and soil have been claimed to disintegrate rapidly over the course of a few months, which would make them unacceptable for products that need to have long-term stability when exposed to water and oil. Coco (coir) fiber has been said to be much more suitable, due to higher lignin content (40%–50%, compared to 2%–5% in bast fibers); these are much cheaper than flax and hemp fibers (Karus et al. 2000). However, this analysis does not do justice to the developing hemp geotextile market. Production of hemp erosion control mats is continuing in both Europe and Canada. Given the reputation for rot resistance of hemp canvas and rope, it seems probable that ground matting is a legitimate use. Moreover, the ability to last outdoors for many years is frequently undesirable in geotextiles. For example, the widespread current use of plastic netting to reinforce grass sod is quite objectionable, the plastic persisting for many years and interfering with lawn care. Related to geotextile applications is the possibility of using hemp fiber as a planting substrate (biodegradable pots and blocks for plants), and as biodegradable twine to replace plastic ties used to attach plants to supporting poles. Still another consideration is the “green ideal” of producing locally for local needs; by this credo, hemp is preferable in temperate regions to the use of tropical fibers, which need to be imported.
Traditionally, hemp stalks would be water-retted first before the fibers were beaten off the inner hurd by hand, a process known as scutching. As mechanical technology evolved, separating the fiber from the core was accomplished by crushing rollers and brush rollers that would produce a nearly clean fiber. After the Marijuana Tax Act was implemented in 1938, the technology for separating the fibers from the core remained "frozen in time".

Salve, scusate la domanda banale. La titolazione al 10% indica 1000 mg. Questo vuole indicare che in ogni goccia ci sono 1000 mg di CBD? Io soffro di dolore cronico, fibromialgia, colon irritabile. Voglio acquistare la titolazione alta ma non comprendo perfettamente il dosaggio. Sulla base della vostra tabella patologia/dosaggio ho letto di usare 20 mg per circa 25 giorni..ma non capisco a questo punto come regolarmi. Mi sapreste indicare voi in gocce come devo utilizzarlo? Grazie
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The reason so many people are interested in cannabis products that don’t make them high, proponents say, is that CBD helps with everything from pain and nausea to rheumatoid arthritis, cancer, Crohn’s disease, and dementia. CBD is anti-inflammatory, anti-anxiety, antibacterial, immunosuppressive, and more, says Joseph Cohen, D.O., a cannabis doctor in Boulder, CO.
The seeds are sown from mid-April to mid-May with grain drills to 4–6 cm sowing depth. Hemp needs less fertilizer than corn does. A total of 60–150 kg of nitrogen, 40–140 kg phosphorus (P2O5) and 75–200 kg of potassium [5] per acre for hemp fiber made before sowing and again later, maybe three to four weeks. When practiced, especially in France double use of fiber and seed fertilization with nitrogen doses up to 100 kg / ha rather low. Organic fertilizers such as manure can utilize industrial hemp well. Neither weeds nor crop protection measures are necessary.[52]
The arrival of Epidiolex is unlikely to erase the unregulated CBD market, however. For one, Epidiolex has been studied only in connection with a small number of epileptic conditions. If and when Epidiolex makes its way to drug stores, it will be approved only for the treatment of Dravet Syndrome and Lennox-Gastaut Syndrome, two rare forms of catastrophic epilepsy. People like me, with comparatively mild Janz Syndrome, and people like Harper, with extremely rare conditions like CDKL5, may still be out of luck.
In May of 2018, Mount Vernon planted an industrial cultivar of hemp on the four-acre Pioneer Farm site. Under the 2015 Industrial Hemp Law enacted by the Virginia General Assembly and working with the industrial hemp research program of the University of Virginia, Mount Vernon planted hemp to expand its interpretation of George Washington’s role as an enterprising farmer. As the first historic home of the founding fathers to plant hemp, Mount Vernon will use the plant as an interpretative tool to help better tell the story of Washington’s role as a farmer.
Hemp rope was used in the age of sailing ships, though the rope had to be protected by tarring, since hemp rope has a propensity for breaking from rot, as the capillary effect of the rope-woven fibers tended to hold liquid at the interior, while seeming dry from the outside.[42] Tarring was a labor-intensive process, and earned sailors the nickname "Jack Tar". Hemp rope was phased out when Manila, which does not require tarring, became widely available. Manila is sometimes referred to as Manila hemp, but is not related to hemp; it is abacá, a species of banana.

Down the line, Johnson also plans to create an onsite grow-space in the large two-story building where he's set up shop. In addition to getting deep satisfaction from the relief that customers say his CBD products provide, Johnson remains enthralled with "the fun side" of hemp production: namely, planting a seed and letting it grow. "It's just like in life," he added. "I can't say enough about the process, about the feeling of actually producing something."
Some immediate undesired side effects include a decrease in short-term memory, dry mouth, impaired motor skills and reddening of the eyes.[49] Aside from a subjective change in perception and mood, the most common short-term physical and neurological effects include increased heart rate, increased appetite and consumption of food, lowered blood pressure, impairment of short-term and working memory,[50][51] psychomotor coordination, and concentration.
Harper was diagnosed as an infant with CDKL5, a rare genetic condition doctors only discovered in 2004 and that afflicts roughly 600 people worldwide. The disorder shares its name with the minute particle of DNA it affects, a gene responsible for the production of a protein crucial for neurological development. Symptoms of CDKL5 include intellectual disability, developmental delays, breathing and vision problems, limited or absent speech, poor muscle tone, and, perhaps worst of all, frequent seizures.
The way I see it, the marriage of China’s position as the world’s supplier of hemp -- and its burgeoning semiconductor industry -- could be the key to China’s hegemony over the microchip industry. Semiconductors are traditionally made using silicon. Graphene semiconductors, however, could one day lead to computers that are a thousand times faster, consume significantly less power and are smaller than silicon semiconductors used in computer transistors. In application, graphene’s dwindling supply and costly manufacturing issues would still exist. Putting this all together, Mitlin’s research has sparked interest in the potential for hemp to create the next-generation semiconductor.
Fig. 3. Photograph of Cannabis sativa. Left, staminate (“male”) plant in flower; right, pistillate (“female”) plant in flower. Fig. 4. United States National Institute of Health, University of Mississippi marijuana plantation site, showing variation in plant size. A tall fiber-type of hemp plant is shown at left, and a short narcotic variety (identified as “Panama Gold”) at right.
Going forward, another emerging trend among recreational users are wellness lifestyles built around cannabis. This is certainly part of the influence of California’s new recreational marijuana market, which went online January 1, 2018. California is already an epicenter for health and wellness lifestyles and fads. Expect to see more of the same now that cannabis is completely legal.
For profitable hemp farming, particularly deep, humus-rich, nutrient-rich soil with controlled water flow is preferable. Waterlogged acidic, compressed or extremely light (sandy) soils primarily affect the early development of plants.[citation needed] Steep and high altitudes of more than 400 m above sea level are best avoided. Hemp is relatively insensitive to cold temperatures and can withstand frost down to −5 °C.[citation needed] Seeds can germinate down to 1–3 °C.[citation needed] Hemp needs a lot of heat, so earlier varieties come to maturation. The water requirement is 300–500 l/kg dry matter.[citation needed] This is around 1/14th that of cotton, which takes between 7,000 and 29,000 l/kg, according to WWF.[citation needed] Roots can grow up to 3 feet into the soil and use water from deeper soil layers.

Cannabis sativa L. subsp. sativa var. sativa is the variety grown for industrial use, while C. sativa subsp. indica generally has poor fiber quality and female buds from this variety are primarily used for recreational and medicinal purposes. The major differences between the two types of plants are the appearance, and the amount of Δ9-tetrahydrocannabinol (THC) secreted in a resinous mixture by epidermal hairs called glandular trichomes, although they can also be distinguished genetically.[55][57] Oilseed and fiber varieties of Cannabis approved for industrial hemp production produce only minute amounts of this psychoactive drug, not enough for any physical or psychological effects. Typically, hemp contains below 0.3% THC, while cultivars of Cannabis grown for medicinal or recreational use can contain anywhere from 2% to over 20%.[58]
Prior to 2005's Hurricane Katrina, which caused widespread destruction and fatalities across New Orleans, Johnson had moved to California, and spent years there soaking up knowledge and culture around cannabis plants and the industry. After witnessing the pain and nausea his mother experienced during her treatment, Johnson decided to help bring the medicinal and economic value of cannabis back to his hometown, starting with hemp.
Hemp seeds have an attractive nutty taste, and are now incorporated into many food preparations (Fig. 34), often mimicking familiar foods. Those sold in North America include nutritional (granola-type) or snack bars, “nut butters” and other spreads, bread, pretzels, cookies, yogurts, pancakes, porridge, fruit crumble, frozen dessert (“ice cream”), pasta, burgers, pizza, salt substitute, salad dressings, mayonnaise, “cheese,” and beverages (“milk,” “lemonade,” “beer,” “wine,” “coffee nog”). Hemp seed is often found canned or vacuum-packed (Fig. 35). Alcoholic beverages made with hemp utilize hempseed as a flavorant. Hemp food products currently have a niche market, based particularly on natural food and specialty food outlets.
Cannabidiol has been found to act as an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain.[35] It has also been found to act as an inverse agonist of GPR3, GPR6, and GPR12.[12] Although currently classified as orphan receptors, these receptors are most closely related phylogeneticaly to the cannabinoid receptors.[12] In addition to orphan receptors, CBD has been shown to act as a serotonin 5-HT1A receptor partial agonist,[36] and this action may be involved in its antidepressant,[37][38] anxiolytic,[38][39] and neuroprotective effects.[40][41] It is an allosteric modulator of the μ- and δ-opioid receptors as well.[42] The pharmacological effects of CBD have additionally been attributed to PPARγ agonism and intracellular calcium release.[8]
Separate levels of evidence scores are assigned to qualifying human studies on the basis of statistical strength of the study design and scientific strength of the treatment outcomes (i.e., endpoints) measured. The resulting two scores are then combined to produce an overall score. An overall level of evidence score cannot be assigned to cannabinoids because there has been insufficient clinical research. For an explanation of possible scores and additional information about levels of evidence analysis of CAM treatments for people with cancer, refer to Levels of Evidence for Human Studies of Integrative, Alternative, and Complementary Therapies.

Users have reported toxic symptoms, extreme reactions and serious psychological problems from using synthetic cannabis. These include: high blood, pressure, abdominal pain, nausea and vomiting, chest pain, heart palpitations, severe anxiety and paranoia, fear of dying, hallucinations, tremors and seizures, violent behaviour, and suicidal thoughts. These toxic symptoms have lasting several days and others have experienced long term mental health issues. Tolerance can develop quickly which means you will need more to get the same effect.

All this talk about THC lands us nicely in the whole “Full Spectrum vs. Pure Isolate” debate. Once you begin shopping for CBD products, you’ll notice a lot of jargon that gets thrown around without much explanation. Now that we’ve introduced THC into the conversation, we can talk about the difference between, and relative benefits of, Full Spectrum CBD and CBD Isolate (and the lesser-known contender: Broad Spectrum).

Side effects of CBD include sleepiness, decreased appetite, diarrhea, fatigue, malaise, weakness, sleeping problems, and others.[3] It does not have intoxicating effects like those caused by THC, and may have an opposing effect on disordered thinking and anxiety produced by THC.[7][10][11] CBD has been found to interact with a variety of different biological targets, including cannabinoid receptors and other neurotransmitter receptors.[7][12] The mechanism of action of CBD in terms of its psychoactive and therapeutic effects is not fully clear.[7]
Donald Abrams was a member of the committee that reviewed the evidence that went into producing the report, and he said that the studies they reviewed overwhelmingly used pharmaceutically available preparations that contain THC, including dronabinol, nabilone and the whole-plant extract spray nabiximols, which contains equal parts CBD and THC. It’s impossible to know whether the benefits of cannabis can also be obtained from CBD alone, Abrams said, because CBD is just one of 400 chemicals present in the plant. So far, CBD in isolation has been studied in only a handful of randomized, placebo-controlled trials (considered the gold standard of evidence in medical research), and the evidence remains sparse.
On the federal level, several bills currently before Congress seek to change the way the government treats CBD. One such bill, the Compassionate Access Act, would exclude CBD from the classification of “marijuana” and remove both from the DEA’s list of Schedule I controlled substances. Rescheduling CBD in such a way would make research and cultivation of CBD much easier.
It sounds like the title of a children’s book, but like so much else that you learned in kindergarten, it’s true. Everyone’s body is different – but everyone’s endocannabinoid system is really unique. For reasons we don’t fully understand, receptors in the endocannabinoid system don’t respond predictably to cannabinoids from person to person. This lack of a predictable response makes standard dosing tricky.

That leaves those touting CBD’s effectiveness pointing primarily to research in mice and petri dishes. There, CBD (sometimes combined with small amounts of THC) has shown promise for helping pain, neurological conditions like anxiety and PTSD, and the immune system—and therefore potentially arthritis, diabetes, multiple sclerosis, cancer, and more.


CBC is another lesser-known yet still crucial cannabinoid in marijuana, especially from a therapeutic perspective. While bereft of the psychoactive quality of THC (and to a lesser extent THCV), CBC is gaining popularity as an anxiety reducer. While research on cannabichromene lags behind others, there’s good reason to continue looking into its potential as a medicine.
Jump up ^ Nadulski T, Pragst F, Weinberg G, Roser P, Schnelle M, Fronk EM, Stadelmann AM (December 2005). "Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract". Ther Drug Monit. 27 (6): 799–810. PMID 16306858.
Its sturdy fibers have also been put to growing use in high-quality plastics and auto paneling, durable building materials, and other common industrial commodities. And when it comes to environmental impact, hemp is not only a low-fuss crop capable of flourishing in US farmland; it can also clean up tainted water and soil, bully weeds away, and be converted into biodiesel.
Jump up ^ Devinsky, Orrin; Cilio, Maria Roberta; Cross, Helen; Fernandez-Ruiz, Javier; French, Jacqueline; Hill, Charlotte; Katz, Russell; Di Marzo, Vincenzo; Jutras-Aswad, Didier; Notcutt, William George; Martinez-Orgado, Jose; Robson, Philip J.; Rohrback, Brian G.; Thiele, Elizabeth; Whalley, Benjamin; Friedman, Daniel (22 May 2014). "Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders". Epilepsia. 55 (6): 791-802. doi:10.1111/epi.12631. PMC 4707667. PMID 24854329.

France is Europe's biggest producer (and the world's second largest producer) with 8,000 hectares cultivated.[80] 70-80% of the hemp fibre produced in 2003 was used for specialty pulp for cigarette papers and technical applications. About 15% was used in the automotive sector, and 5-6% was used for insulation mats. About 95% of hurds were used as animal bedding, while almost 5% was used in the building sector.[14] In 2010/2011, a total of 11,000 hectares (27,000 acres) was cultivated with hemp in the EU, a decline compared with previous year.[68][81]
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