μ-Opioid receptor agonists (opioids) (e.g., morphine, heroin, hydrocodone, oxycodone, opium, kratom) α2δ subunit-containing voltage-dependent calcium channels blockers (gabapentinoids) (e.g., gabapentin, pregabalin, phenibut) AMPA receptor antagonists (e.g., perampanel) CB1 receptor agonists (cannabinoids) (e.g., THC, cannabis) Dopamine receptor agonists (e.g., levodopa) Dopamine releasing agents (e.g., amphetamine, methamphetamine, MDMA, mephedrone) Dopamine reuptake inhibitors (e.g., cocaine, methylphenidate) GABAA receptor positive allosteric modulators (e.g., barbiturates, benzodiazepines, carbamates, ethanol (alcohol) (alcoholic drink), inhalants, nonbenzodiazepines, quinazolinones) GHB (sodium oxybate) and analogues Glucocorticoids (corticosteroids) (e.g., dexamethasone, prednisone) nACh receptor agonists (e.g., nicotine, tobacco, arecoline, areca nut) Nitric oxide prodrugs (e.g., alkyl nitrites (poppers)) NMDA receptor antagonists (e.g., DXM, ketamine, methoxetamine, nitrous oxide, phencyclidine, inhalants) Orexin receptor antagonists (e.g., suvorexant)
The vegetable oils have been classified by “iodine value” as drying (120–200), semi-drying (100–120), and non-drying (80–100), which is determined by the degree of saturation of the fatty acids present (Raie et al. 1995). Good coating materials prepared from vegetable oil depend on the nature and number of double bonds present in the fatty acids. Linseed oil, a drying oil, has a very high percentage of linolenic acid. Hempseed oil has been classified as a semi-drying oil, like soybean oil, and is therefore more suited to edible than industrial oil purposes. Nevertheless hemp oil has found applications in the past in paints, varnishes, sealants, lubricants for machinery, and printing inks. However, such industrial end uses are not presently feasible as the oil is considered too expensive (de Guzman 2001). Larger production volumes and lower prices may be possible, in which case hemp oil may find industrial uses similar to those of linseed (flax), soybean, and sunflower oils, which are presently used in paints, inks, solvents, binders, and in polymer plastics. Hemp shows a remarkable range of variation in oil constituents, and selection for oilseed cultivars with high content of valued industrial constituents is in progress.

CBD does not appear to have any psychotropic ("high") effects such as those caused by ∆9-THC in marijuana, but may have anti-anxiety and anti-psychotic effects.[10] As the legal landscape and understanding about the differences in medical cannabinoids unfolds, it will be increasingly important to distinguish "medical marijuana" (with varying degrees of psychotropic effects and deficits in executive function) – from "medical CBD therapies” which would commonly present as having a reduced or non-psychoactive side effect profile.[10][60]


My mom is late stage dementia. We have tried coconut oil/black pepper/curcumin combo for years. Gives only tine bit of help, and is not something that reverses dementia. Maybe in someone who can score better than a 14 on the mme it could be of help. But cannabinoid is a different story. Cannabinoids produce better results in less time. Can't say yet that they will reverse anything though.


As provided in Sec. 7606 of the 2014 Farm Bill industrial hemp may only be grown as part of a research or pilot project.  The 108th General Assembly enacted Public Chapter 916 regarding the growing of industrial hemp in Tennessee. The Act removes industrial hemp from the definition of marijuana in the criminal code. The cultivation of industrial hemp is now available as an option for Tennessee farmers on a limited basis. The Commissioner of the Tennessee Department of Agriculture has promulgated regulations establishing a program of licensing authorized hemp producers.
The word cannabis is from Greek κάνναβις (kánnabis) (see Latin cannabis),[134] which was originally Scythian or Thracian.[135] It is related to the Persian kanab, the English canvas and possibly even to the English hemp (Old English hænep).[135] In modern Hebrew, קַנַּבּוֹס‬ qannabōs (modern pronunciation: [kanaˈbos]) is used but there are those who have theorized that it was referred to in antiquity as קני בושם q'nei bosem, a component of the biblical anointing oil.[136][137] Old Akkadian qunnabtu, Neo-Assyrian and Neo-Babylonian qunnabu were used to refer to the plant meaning "a way to produce smoke".[138][139][140]
Specific city and county laws have been enacted to regulate how citizens and tourists may possess and consume marijuana. Penalties exist for driving while under the influence of marijuana. Someone driving under the influence of marijuana is considered impaired in both Colorado and Washington when five nanograms per milliliter (ng/mL) of blood or more of active THC is detected.
As detailed below, the development of hemp as a new legal crop in North America must be considered in relation to illicit cultivation, so it is important to appreciate the scope of the drug situation. Up until the first half of the 20th century, drug preparations of Cannabis were used predominantly as a recreational inebriant in poor countries and the lower socio-economic classes of developed nations. After World War II, marijuana became associated with the rise of a hedonistic, psychedelic ethos, first in the United States and eventually over much of the world, with the consequent development of a huge international illicit market that exceeds the value of the hemp market during its heyday. Table 3 shows the “economic significance” (dollars generated in the black market plus dollar cost of control measures) of the illicit drug industry associated with C. sativa, and contrasts this with the estimated dollar value of major categories of legitimate uses. In the Netherlands, the annual value of narcotic hemp cultivation (ca. $10 billion) exceeds the value of tulips (Collins 1999). Marijuana has become the most widely disseminated illicit species in the world (Schultes and Hofmann 1980). With the exception of alcohol, it is the most widely used recreational euphoric drug. About 25% of North Americans are believed to have used Cannabis illegally. According to the US National Institute on Drug Abuse (www.nida.nih.gov/Infofax/marijuana.html), more than 72 million Americans (33%) 12 years of age and older have tried marijuana. Cultivation, commerce, and consumption of drug preparations of Cannabis have been proscribed in most countries during the present century. The cost of enforcing the laws against Cannabis in North America is in the billions of dollars annually. In addition, there are substantial social costs, such as adverse effects on users, particularly those who are convicted. Tragically this includes some legitimate farmers who, faced with financial ruin because of the unprofitability of crops being grown, converted to growing marijuana.

My mom is late stage dementia. We have tried coconut oil/black pepper/curcumin combo for years. Gives only tine bit of help, and is not something that reverses dementia. Maybe in someone who can score better than a 14 on the mme it could be of help. But cannabinoid is a different story. Cannabinoids produce better results in less time. Can't say yet that they will reverse anything though.
^ Jump up to: a b c Whiting, PF; Wolff, RF; Deshpande, S; Di Nisio, M; Duffy, S; Hernandez, AV; Keurentjes, JC; Lang, S; Misso, K; Ryder, S; Schmidlkofer, S; Westwood, M; Kleijnen, J (23 June 2015). "Cannabinoids for Medical Use: A Systematic Review and Meta-analysis" (PDF). JAMA. 313 (24): 2456–2473. doi:10.1001/jama.2015.6358. hdl:10757/558499. PMID 26103030.
There are hundreds of compounds in marijuana, but scientists believe the one responsible for the drugs' psychoactive effects is tetrahydrocannbinol, or THC. THC binds to cannabinoid receptors throughout the body, and marijuana's "high" comes from THC's binding to brain regions responsible for pleasure, time perception and pain, according to the National Institute on Drug Abuse (NIDA). 
At least 50% of patients who receive moderately emetogenic chemotherapy may experience delayed chemotherapy-induced N/V. Although selective neurokinin 1 antagonists that inhibit substance P have been approved for delayed N/V, a study was conducted before their availability to assess dronabinol, ondansetron, or their combination in preventing delayed-onset chemotherapy-induced N/V.[34] Ondansetron, a serotonin 5-hydroxytryptamine 3 (5-HT3) receptor antagonist, is one of the mainstay agents in the current antiemetic armamentarium. In this trial, the primary objective was to assess the response 2 to 5 days after moderately to severely emetogenic chemotherapy. Sixty-one patients were analyzed for efficacy. The total response–a composite endpoint–including nausea intensity, vomiting/retching, and use of rescue medications, was similar with dronabinol (54%), ondansetron (58%), and combination therapy (47%) when compared with placebo (20%). Nausea absence was greater in the active treatment groups (dronabinol 71%, ondansetron 64%, combination therapy 53%) when compared with placebo (15%; P < .05 vs. placebo for all). Occurrence rates for nausea intensity and vomiting/retching episodes were the lowest in patients treated with dronabinol, suggesting that dronabinol compares favorably with ondansetron in this situation where a substance P inhibitor would currently be the drug of choice.
Cannabidiol is currently a class B1 controlled drug in New Zealand under the Misuse of Drugs Act. It is also a prescription medicine under the Medicines Act. In 2017 the rules were changed so that anyone wanting to use it could go to the Health Ministry for approval. Prior to this, the only way to obtain a prescription was to seek the personal approval of the Minister of Health.
Jump up ^ Parliament of the Czech Republic (1998), Explanatory Report to Act No. 112/1998 Coll., which amends the Act No. 140/1961 Coll., the Criminal Code, and the Act No. 200/1990 Coll., on misdemeanors (in Czech), Prague "Podle čl. 36 Jednotné úmluvy o omamných látkách ze dne 31. března 1961 (č. 47/1965 Sb.) se signatáři zavazují k trestnímu postihu tam uvedených forem nakládání s drogami včetně jejich držby. Návrh upouští od dosavadní beztrestnosti držby omamných a psychotropních látek a jedů pro svoji potřebu. Dosavadní beztrestnost totiž eliminuje v řadě případů možnost postihu dealerů a distributorů drog."

Cannabis is by far the most widely cultivated, trafficked and abused illicit drug. Half of all drug seizures worldwide are cannabis seizures. The geographical spread of those seizures is also global, covering practically every country of the world. About 147 million people, 2.5% of the world population, consume cannabis (annual prevalence) compared with 0.2% consuming cocaine and 0.2% consuming opiates. In the present decade, cannabis abuse has grown more rapidly than cocaine and opiate abuse. The most rapid growth in cannabis abuse since the 1960s has been in developed countries in North America, Western Europe and Australia. Cannabis has become more closely linked to youth culture and the age of initiation is usually lower than for other drugs. An analysis of cannabis markets shows that low prices coincide with high levels of abuse, and vice versa. Cannabis appears to be price-inelastic in the short term, but fairly elastic over the longer term. Though the number of cannabis consumers is greater than opiate and cocaine consumers, the lower prices of cannabis mean that, in economic terms, the cannabis market is much smaller than the opiate or cocaine market.

Salve, scusate la domanda banale. La titolazione al 10% indica 1000 mg. Questo vuole indicare che in ogni goccia ci sono 1000 mg di CBD? Io soffro di dolore cronico, fibromialgia, colon irritabile. Voglio acquistare la titolazione alta ma non comprendo perfettamente il dosaggio. Sulla base della vostra tabella patologia/dosaggio ho letto di usare 20 mg per circa 25 giorni..ma non capisco a questo punto come regolarmi. Mi sapreste indicare voi in gocce come devo utilizzarlo? Grazie
Public heath insurance programs would be required to cover medical marijuana in New York if a new Assembly bill is enacted. “Cost is the primary barrier to patient access in New York’s medical marijuana program,” reads a memo attached to the legislation. “Medicaid, other public health plans, and commercial health insurance plans do not cover … Continue reading New York Bill Would Require Medical Marijuana Be Covered By Public Health Insurance

Several animal studies have led researchers to believe that cannabis could reverse signs of aging in the brain. Aging mice treated with small daily doses of THC showed a reversal in cognitive decline. However, past studies on the effects of cannabis on human memory show less promising results. Still, with few viable treatments for dementia, medical marijuana is receiving increased attention in this area.
Every crop grown and every variety may be inspected and sampled by a TDA plant inspector prior to harvest. The grower should contact TDA 30 days prior to harvest for inspection. The license holder is responsible for paying all fees associated with the sample. Each sample is $150. Please keep in mind that the way you set up your production method, may influence the number of samples required to represent the amount of material being produced. Growing multiple varieties will also increase the sampling cost.
Ten years ago hemp cultivation was illegal in Germany, England, Canada, Australia, and other countries. Essential to overcoming governmental reluctance in each country was the presentation of an image that was business-oriented, and conservative. The merits of environmentalism have acquired some political support, but unless there is a reasonable possibility that hemp cultivation is perceived as potentially economically viable, there is limited prospect of having anti-hemp laws changed. Strong support from business and farm groups is indispensable; support from pro-marijuana interests and what are perceived of as fringe groups is generally counterproductive. It is a combination of prospective economic benefit coupled with assurance that hemp cultivation will not detrimentally affect the enforcement of marijuana legislation that has led most industrially advanced countries to reverse prohibitions against growing hemp. Should the US permit commercial hemp cultivation to resume, it will likely be for the same reasons.
Hemp, the non-psychoactive variety of the cannabis sativa plant, is already being integrated into several mature markets such as food, textiles, construction, personal care and nutraceuticals. This relatively quiet cannabis relative is emerging as a potential commodity ripe to not only impact, but possibly revolutionize, tech-driven markets and economies around the world.
Liquid CBD Oil/Tinctures/Extracts: Drops or tinctures should have a “suggested serving size” and the total milligrams of CBD listed on their packaging. From there, you can determine the amount of CBD you would like to ingest. Simply place the correct quantity of drops under your tongue using the dropper and hold the CBD oil in place for a minimum of 60 seconds. The 60 second hold allows for absorption via the blood vessels underneath your tongue – efficiently bypassing first-pass metabolism. Once 60 seconds has passed, swallow the CBD oil.
But, uh, what is it that CBD is supposed to do? I visited a cannabis dispensary in Boulder to find out what the hype was all about. After passing an ID check, I was introduced to a “budtender” who pointed me to an impressive array of CBD products — tinctures, skin patches, drink powders, candies, salves, massage oil, lotions, “sexy time personal intimacy oil” and even vaginal suppositories to treat menstrual cramps.
"Industrial hemp" means a fiber or oilseed crop, or both, that is limited to types of the plant Cannabis sativa L. having no more than three-tenths of 1 percent tetrahydrocannabinol (THC) contained in the dried flowering tops, whether growing or not; the seeds of the plant; the resin extracted from any part of the plant; and every compound, manufacture, salt, derivative, mixture, or preparation of the plant, its seeds or resin produced therefrom.
...with due respect, your experience Locsta is almost precisely what happened with my....chihuahua. Degenerative disc disease, excruciating pain, prednisone worked, but couldn't keep her on it..pain killers and muscle relaxants didn't help, really thought I would have to put her down. Chi bloggers suggested CBD; gave PetReleaf a shot--like you, literally within minutes I could see the difference, in days she was pain free and now is back in charge of our world. The real key here is that with my dog, there is zero, nada, chance that there was any placebo effect...
Tocopherols. Tocopherols are major antioxidants in human serum. Alpha- beta-, gamma- and delta-tocopherol represent the vitamin E group. These fat-soluble vitamins are essential for human nutrition, especially the alpha-form, which is commonly called vitamin E. About 80% of the tocopherols of hempseed oil is the alpha form. The vitamin E content of hempseed is comparatively high. Antioxidants in hempseed oil are believed to stabilize the highly polyunsaturated oil, tending to keep it from going rancid. Sterols in the seeds probably serve the same function, and like the tocopherols are also desirable from a human health viewpoint.
My Wife had Polio at age 5 and the lingering damage to the L leg and muscle drove her crazy. At age 21 she was using heavy doses of muscle relaxers and pain meds. Needed to bomb herself at night to get some sleep. A Post polio group in West Palm Beach told her about Marijuana and she got some from the Jamaican health aide that was her constant helper. After 5 months she quit all meds. All of them. Slowly came out of the drugged state the meds had caused from 15 years of use. We separated good friends and I know she has gone back to school and getting a degree. All from the help of a plant from Jamaica. I never understood the statement this plant has no viable medical value. Something smells in the politics of this prohibition. Shame.

Public heath insurance programs would be required to cover medical marijuana in New York if a new Assembly bill is enacted. “Cost is the primary barrier to patient access in New York’s medical marijuana program,” reads a memo attached to the legislation. “Medicaid, other public health plans, and commercial health insurance plans do not cover … Continue reading New York Bill Would Require Medical Marijuana Be Covered By Public Health Insurance


Nabiximols (Sativex), a Cannabis extract with a 1:1 ratio of THC:CBD, is approved in Canada (under the Notice of Compliance with Conditions) for symptomatic relief of pain in advanced cancer and multiple sclerosis.[17] Canada, New Zealand, and some countries in Europe also approve nabiximols for spasticity of multiple sclerosis, a common symptom that may include muscle stiffness, reduced mobility, and pain, and for which existing therapy is unsatisfactory.
Content on this website is provided for information purposes only. Information about a therapy, service, product or treatment does not in any way endorse or support such therapy, service, product or treatment and is not intended to replace advice from your doctor or other registered health professional. The information and materials contained on this website are not intended to constitute a comprehensive guide concerning all aspects of the therapy, product or treatment described on the website. All users are urged to always seek advice from a registered health care professional for diagnosis and answers to their medical questions and to ascertain whether the particular therapy, service, product or treatment described on the website is suitable in their circumstances. The State of Victoria and the Department of Health & Human Services shall not bear any liability for reliance by any user on the materials contained on this website.
Each and every bottle is grown and processed with the same standards as the last guaranteeing quality and assuring potency. Made from CBD rich hemp flower sun grown in Oregon and MCT oil, Rosebud is proud to be a Vegan, Gluten Free, Non-GMO, Organic, and Sustainably Processed CO2 extract. Choose between our three potencies: 350mg, 700mg and 1000mg. 
Out of the 17 states that have passed CBD-only laws, five— Missouri, Florida, Mississippi, Louisiana, and Texas—would also establish licensed cultivation centers to grow high-CBD strains of cannabis, which could be turned into oils and other CBD products. This would cut down on the demand for CBD oil from unregulated manufacturers abroad. Even then, though, impediments remain. In Missouri, for example, two neurologists recently refused to prescribe CBD oil for an eight- year-old boy suffering from seizures, citing concerns over federal law and the safety of non-FDA approved products.

Canadian experience with growing hemp commercially for the last 4 years has convinced many growers that it is better to use a single-purpose cultivar, seed or fiber, than a dual-purpose cultivar. The recent focus of Canadian hemp breeders has been to develop cultivars with high seed yields, low stature (to avoid channeling the plants’ energy into stalk, as is the case in fiber cultivars), early maturation (for the short growing seasons of Canada), and desirable fatty acid spectrum (especially gamma-linolenic acid).
Pinfold Consulting. 1998. (G. Pinfold Consulting Economists Ltd. and J. White, InfoResults Ltd.). A maritime industrial hemp product marketing study. Prepared for Nova Scotia Agriculture and Marketing (Marketing and Food Industry Development), and New Brunswick Agriculture & Rural Development (Marketing and Business Development). agri.gov.ns.ca/pt/agron/hemp/hempms.htm

I have severe neuropathy in both feet and legs. I just got the CBD oil and I am interested in learning if anyone out there has had any success with this. I know each case and pain levels are different. Just would like to see some positive remarks from people who suffer with it. I am not looking for a cure just need an update on someone who took and it helped. I already know there is no cure. I need help with the pain. Thank you.
Thank you for sharing your story. It is amazing the stories I have heard and the things you here the politicians debating over. The truth is out. They need to get over there guilty pride and pharmaceutical needs to be slapped down a few pegs. This is happening we just need to defend the corporations that back the oil, the pharma, any other corporation that doesn’t fight a health and balance model.
Henry Ford recognized the utility of hemp in early times. In advance of today’s automobile manufacturers, he constructed a car with certain components made of resin stiffened with hemp fiber (Fig. 19). Rather ironically in view of today’s parallel situation, Henry Ford’s hemp innovations in the 1920s occurred at a time of crisis for American farms, later to intensify with the depression. The need to produce new industrial markets for farm products led to a broad movement for scientific research in agriculture that came to be labeled “Farm Chemurgy,” that today is embodied in chemical applications of crop constituents.

								   What is cannabis?Cannabis is a drug that comes from Indian hemp plants such as Cannabis sativa and Cannabis indica. The main active chemical in cannabis is THC (delta-9 tetrahydrocannabinol).Cannabis is a depressant drug. Depressant drugs do not necessarily make you feel depressed. Rather, they slow down the activity of the central nervous system and the messages going between the brain and the body. When large doses of cannabis are taken it may also produce hallucinogenic effects.For information on synthetic cannabinoids, see our "Legal high" facts page.Other namesCannabis is also known as grass, pot, hash, weed, reefer, dope, herb, mull, buddha, ganja, joint, stick, buckets, cones, skunk, hydro, yarndi, smoke and hooch.What does cannabis look like?Leaves from the cannabis plant are bright green and have a distinctive shape with five or seven leaflets. The flowering tops and upper leaves are covered in a sticky resin.Cannabis is used for the psychoactive (mind and mood-altering) effects of THC and other active ingredients. THC is the chemical in cannabis that makes you feel “high”.There are three main forms of psychoactive cannabis: marijuana, hashish and hash oil.Marijuana is the most common and least potent form of cannabis. Marijuana is the dried leaves and flowers of the plant.Hashish (“hash”) is dried cannabis resin, usually in the form of a small block. The concentration of THC in hashish is higher than in marijuana, producing stronger effects.Hash oil is a thick, oily liquid, golden brown to black in colour, which is extracted from cannabis. Hash oil is the strongest form of cannabis.How and why is it used?The different forms of cannabis are used in different ways:Marijuana is smoked in hand-rolled cigarettes (joints), or in a pipe (a bong).Hashish is usually added to tobacco and smoked, or baked and eaten in foods such as hash cookies.Hash oil is usually spread on the tip or paper of a cigarette and then smoked.Cannabis and hash can also be smoked in a vaporiser. Vaporisers heat cannabis to temperatures that release its active ingredients while minimising the toxins associated with burning.The THC in cannabis is absorbed into the bloodstream through the walls of the lungs (if smoked), or through the walls of the stomach and intestines (if eaten). The bloodstream carries the THC to the brain, producing the “high” effects. Drugs inhaled get into the bloodstream quicker than those eaten. This means that the effects of cannabis when smoked occur more rapidly than when eaten.Paper and textilesSome species of cannabis have few psychoactive effects. These plants are used to produce hemp fibre for use in paper, textiles and clothing.Medical usesCannabis has been used for medical purposes for many centuries. It has been reported that cannabis may be useful to help conditions such as:nausea and vomiting, particularly when associated with chemotherapywasting and severe weight loss, in people with HIV/AIDS, cancer, or anorexia nervosa, as it may be used as an appetite stimulantpain relief, for example in people with cancer and arthritisrelief from symptoms of some neurological disorders that involve muscle spasms, including multiple sclerosis and spinal cord injuryglaucomaepilepsyasthma.For more information, please click on the Australian Drug Foundation's DrugInfo Clearinghouse web site link below.

A cross-sectional survey of cancer patients seen at the Seattle Cancer Care Alliance was conducted over a 6-week period between 2015 and 2016.[18] In Washington State, Cannabis was legalized for medicinal use in 1998 and for recreational use in 2012. Of the 2,737 possible participants, 936 (34%) completed the anonymous questionnaire. Twenty-four percent of patients considered themselves active Cannabis users. Similar numbers of patients inhaled (70%) or used edibles (70%), with dual use (40%) being common. Non–mutually exclusive reasons for Cannabis use were physical symptoms (75%), neuropsychiatric symptoms (63%), recreational use/enjoyment (35%), and treatment of cancer (26%). The physical symptoms most commonly cited were pain, nausea, and loss of appetite. The majority of patients (74%) stated that they would prefer to obtain information about Cannabis from their cancer team, but less than 15% reported receiving information from their cancer physician or nurse.
The earliest recorded uses date from the 3rd millennium BC.[32] Since the early 20th century, cannabis has been subject to legal restrictions. The possession, use, and sale of cannabis is illegal in most countries of the world.[33][34] Medical cannabis refers to the physician-recommended use of cannabis, which takes place in Canada, Belgium, Australia, the Netherlands, Germany, Spain, and 31 U.S. states.[35] In September 2018 cannabis was legalized in South Africa[36] while Canada legalized recreational use of cannabis in October 2018.[37]

"CBD increases the circulating levels of your natural endocannabinoids, which, in turn, interact with your cannabinoid receptors," Bonn-Miller says. "CBD has also been shown to interact with serotonin receptors, and that may be part of why it has some beneficial effects on anxiety. It also interacts with some pain receptors, which may be why we're starting to see effects on pain and inflammation."
In late 2017, researchers with the University of Guelph in Canada published the first-ever study to document the ideal growing conditions for cannabis. Using liquid organic fertilizer with a PKN ratio of 1.3P–1.7K-4.0N, the experiment tested five increasing rates of fertilization. They also tested two coir-based soil-less growing media, or “substrates.”

Cannabis can be prepared into various foods generally called ‘edibles’. It takes between 1-3 hours to feel the effects after eating cannabis.2 Impatient or naïve users may believe they have not taken enough to feel the effects, and if they consume more they may find later that the psychoactive effects are unpleasantly strong. When edible products have inconsistent levels of THC even experienced users may find it difficult to regulate the amount consumed.
Pain management improves a patient’s quality of life throughout all stages of cancer. Through the study of cannabinoid receptors, endocannabinoids, and synthetic agonists and antagonists, the mechanisms of cannabinoid-induced analgesia have been analyzed.[46][Level of evidence:1iC] The CB1 receptor is found in the central nervous system (CNS) and in peripheral nerve terminals.[47] CB2 receptors are located mainly in peripheral tissue and are expressed in only low amounts in the CNS. Whereas only CB1 agonists exert analgesic activity in the CNS, both CB1 and CB2 agonists have analgesic activity in peripheral tissue.[48,49]

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