Not until the end of the 20th century was the specific mechanism of action of THC at the neuronal level studied.[citation needed] Researchers have subsequently confirmed that THC exerts its most prominent effects via its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor, both of which are G protein-coupled receptors.[133] The CB1 receptor is found primarily in the brain as well as in some peripheral tissues, and the CB2 receptor is found primarily in peripheral tissues, but is also expressed in neuroglial cells.[134] THC appears to alter mood and cognition through its agonist actions on the CB1 receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose-dependent manner. These actions can be blocked by the selective CB1 receptor antagonist rimonabant (SR141716), which has been shown in clinical trials to be an effective treatment for smoking cessation, weight loss, and as a means of controlling or reducing metabolic syndrome risk factors.[135] However, due to the dysphoric effect of CB1 receptor antagonists, this drug is often discontinued due to these side effects.[136]
Jump up ^ Vanyukov MM, Tarter RE, Kirillova GP, Kirisci L, Reynolds MD, Kreek MJ, Conway KP, Maher BS, Iacono WG, Bierut L, Neale MC, Clark DB, Ridenour TA (June 2012). "Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective". Drug and Alcohol Dependence (Review). 123 Suppl 1: S3–17. doi:10.1016/j.drugalcdep.2011.12.018. PMC 3600369. PMID 22261179.

Medical cannabis, or medical marijuana, can refer to the use of cannabis and its cannabinoids to treat disease or improve symptoms; however, there is no single agreed-upon definition.[38][39] The rigorous scientific study of cannabis as a medicine has been hampered by production restrictions and other federal regulations.[40] There is limited evidence suggesting cannabis can be used to reduce nausea and vomiting during chemotherapy, to improve appetite in people with HIV/AIDS, and to treat chronic pain and muscle spasms.[41][42][43] Its use for other medical applications is insufficient for conclusions about safety or efficacy.
Today, 30 countries around the world allow farmers to grow industrial hemp, China being the largest producer and exporter. Canada, which produces hemp for food and toiletries, legalized the crop in 1996. The US, on the other hand, has restricted hemp production and categorized hemp in Schedule 1 of the Controlled Substances Act, attributing it as a relative of marijuana.
According to Delphic analysis by British researchers in 2007, cannabis has a lower risk factor for dependence compared to both nicotine and alcohol.[97] However, everyday use of cannabis may be correlated with psychological withdrawal symptoms, such as irritability or insomnia,[93] and susceptibility to a panic attack may increase as levels of THC metabolites rise.[98][99] However, cannabis withdrawal symptoms are typically mild and are never life-threatening.[100]
For most people with epilepsy, diagnosis sets off a gauntlet of trial-and-error attempts to find the right medication. The process is tortuous, with seizures alternately dying down and flaring up while side effects— fatigue, nausea, liver damage, and more—develop without warning. This is partly due to the fact that “epilepsy” is actually a broad category that includes a number of distinct seizure disorders. About 30 medications approved by the U.S. Food and Drug Administration are currently used to treat these conditions, and when a person first begins having seizures, there is often much tinkering with combinations and dosages. I spent years battling side effects like vomiting, dizziness, drowsiness, and severe headaches, which were alleviated only by yet another prescription medication. Parents who endure enough sleepless nights caring for a sick child can become desperate for a cure.
Although hemp can be successfully grown continuously for several years on the same land, rotation with other crops is desirable. A 3- or preferably 4-year rotation may involve cereals, clover or alfalfa for green manure, maize, and hemp. In Ontario it has been recommended that hemp not follow canola, edible beans, soybeans or sunflowers. However, according to Bócsa and Karus (1998), “it matters little what crops are grown prior to hemp.”
The U.S. hemp-derived CBD market alone is projected to reach $450 million by 2020, and China's cannabis market could grow to 100 billion yuan by 2022 (approximately $14.5 billion). Hemp is already interwoven into the futures of the automotive, construction, energy, environmental mediation and technology industries. Once fully utilized and legal, this plant could impact the global economic positionings of North America, China and Africa.
Throughout his lifetime, George Washington cultivated hemp at Mount Vernon for industrial uses. The fibers from hemp held excellent properties for making rope and sail canvas. In addition, hemp fibers could be spun into thread for clothing or, as indicated in Mount Vernon records, used in repairing the large seine nets Washington used in his fishing operation along the Potomac.
In the U.S., we live in a culture where more is often perceived as being better.  And it’s easy, without even thinking about it, to apply that approach to CBD dosing. But when it comes to CBD, more is not necessarily better. In fact, for many, less CBD is more effective. One way to determine your optimal dosage is to start with a small amount of CBD for a couple weeks and then slowly increase your dosage, carefully taking note of symptoms, until you’re seeing the results you want.

Smoking cannabis can have an immediate effect. It can take an hour or more to feel the effects when eaten. Cannabis can make you feel relaxed, giggly, and hungry, or hallucinate or have a dry mouth. Using more cannabis can result in negative effects including blurred vision, bloodshot eyes, feeling sluggish, difficulty concentrating, slower reflexes, increased heart rate and lower blood pressure, and feelings of paranoia and anxiety.
In a new short film produced by Patagonia, Harvesting Liberty, Michael Lewis, a veteran and hemp grower in Kentucky, shares his encounter with the DEA. In 2014, after the passage of the Farm Bill, Lewis was keen to plant hemp in Kentucky. “[But] the DEA didn’t agree that we had a right to plant the crop. They said they would arrest us,” he says in the film. The matter ended up in the Louisville court, where a judge sided with the farmers. “[We] took our seeds up, got them registered and certified, and threw them into the ground before anyone could change their mind,” Lewis says.

George Washington also imported the Indian Hemp plant from Asia, which was used for fiber and, by some growers, for intoxicating resin production. In a letter to William Pearce who managed the plants for him Washington says, "What was done with the Indian Hemp plant from last summer? It ought, all of it, to be sown again; that not only a stock of seed sufficient for my own purposes might have been raised, but to have disseminated seed to others; as it is more valuable than common hemp."[citation needed]

What makes CBD so appealing is that it’s non-intoxicating, so it won’t get you high, though it “is technically psychoactive, because it can influence things like anxiety,” Jikomes said. Although much of the marketing blitz around CBD centers on the fact that you can take it without getting stoned, there isn’t much research looking at the effects of CBD when used in isolation, with a couple of exceptions. One is the use of CBD to treat seizures: CBD is the active ingredient in the only cannabis product that the Food and Drug Administration has signed off on — a drug called Epidiolex, which is approved for treating two rare forms of epilepsy. Animal models and a few human studies suggest that CBD can help with anxiety, but those are the only conditions with much research on CBD in isolation.


CBD’s potential usefulness in treating certain conditions is yet another argument in favor of legalizing the entire cannabis plant. Removing cannabis from the federal list of Schedule I narcotics that are illegal under the Controlled Substances Act would allow scientists to research its full medical potential and pharmaceutical companies in the United States to develop marijuana-based drugs and submit them for FDA approval. Government-regulated labs could test products like CBD oil to ensure safety and quality. Doctors could prescribe marijuana- based medicines with full knowledge of potential side effects and drug interactions, and without fear of losing their medical licenses or being thrown in jail.

Medical cannabis (or medical marijuana) refers to the use of cannabis and its constituent cannabinoids, to treat disease or improve symptoms. Cannabis is used to reduce nausea and vomiting during chemotherapy, to improve appetite in people with HIV/AIDS, and to treat chronic pain and muscle spasms.[102][103] Cannabinoids are under preliminary research for their potential to affect stroke.[104]
Jump up ^ Vanyukov MM, Tarter RE, Kirillova GP, Kirisci L, Reynolds MD, Kreek MJ, Conway KP, Maher BS, Iacono WG, Bierut L, Neale MC, Clark DB, Ridenour TA (June 2012). "Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective". Drug and Alcohol Dependence (Review). 123 Suppl 1: S3–17. doi:10.1016/j.drugalcdep.2011.12.018. PMC 3600369. PMID 22261179.
I have had several neurological conditions like Bells Palsy three times, double vision, paralysis of left side of tongue. I have a lot of relief whenever I have pain by taking an inflamattory drug etoshine90 mg. Presently I have started taking Steroids for my facial palsy. The various pains I was having on the left side of neck, below the left ear, dizziness, pain around the head have subsided immidiately after the first dose of prendisolone 60 mg.I have read that CBD hemp oil can be useful for my condition of neurological and inflammation issues. My question is what concentrate (mg) of the oil should I take and for how long. Any brand that you may suggest that are available in the UK. Thank you.
Thermal Insulation. Thermal insulation products (Fig. 20, 21) are the third most important sector of the hemp industry of the EU. These are in very high demand because of the alarmingly high costs of heating fuels, ecological concerns about conservation of non-renewable resources, and political-strategic concerns about dependence on current sources of oil. This is a market that is growing very fast, and hemp insulation products are increasing in popularity. In Europe, it has been predicted that tens of thousands of tonnes will be sold by 2005, shared between hemp and flax (Karus et al. 2000).
Marijuana looks contrastingly different from hemp. When you observe their leaves, marijuana’s shape tends to either be broad leafed, a tight bud, or look like a nugget with organd hairs.  Hemp, on the other hand, has skinnier leaves that’s concentrated at the top. Few branches or leaves exist below the top part of the plant. When you observe the plants from afar, marijuana looks like a short fat bush. Hemp is typically skinnier and taller (up to 20 ft). At times, it almost looks like long ditchweed – hemp was actually found to grow among weeds in Nebraska. In general, when you compare a marijuana farm with those of industrial hemp, you’ll notice that they are clearly very different from one another.
The CBD utilized in our tinctures is extracted from industrial hemp cultivated in the United States. To further ensure quality and purity, our industrial hemp goes through a supercritical CO2 extraction process to obtain the best possible CBD solution. This solution is then formulated by our board-certified pharmacists into finished products and sent out for third-party testing. Our CBD oil is made with high-quality CBD extracted from organic hemp that is abundant in naturally produced terpenes, oils, vitamins, omega fatty acids, and other components.
Israel, another example, has led the way with ground-breaking research into cannabis cultivation. The country recently recognized medical marijuana as an official part of the nation’s branch of agriculture. Israel is already one of the world’s leading exporters of medical-grade cannabis. Recognizing marijuana cultivation as an official branch of the country’s agriculture will open up even more funds to support Israeli cannabis farmers.
In 1937, the U.S. Treasury Department introduced the Marihuana Tax Act. This Act imposed a levy of $1 per ounce for medicinal use of Cannabis and $100 per ounce for nonmedical use. Physicians in the United States were the principal opponents of the Act. The American Medical Association (AMA) opposed the Act because physicians were required to pay a special tax for prescribing Cannabis, use special order forms to procure it, and keep special records concerning its professional use. In addition, the AMA believed that objective evidence that Cannabis was harmful was lacking and that passage of the Act would impede further research into its medicinal worth.[6] In 1942, Cannabis was removed from the U.S. Pharmacopoeia because of persistent concerns about its potential to cause harm.[2,3]
There is also considerable potential for other industries using hemp in the manner that the automobile industry has demonstrated is feasible. Of course, all other types of transportation vehicles from bicycles to airplanes might make use of such technology. Natural fibers have considerable advantages for use in conveyance (Karus et al. 2000): low density and weight reduction, favorable mechanical, acoustical, and processing properties (including low wear on tools), no splintering in accidents, occupational health benefits (compared to glass fibers), no off-gassing of toxic compounds, and price advantages. Additional types of composite using hemp in combination with other natural fibers, post-industrial plastics or other types of resins, are being used to produce non-woven matting for padding, sound insulation, and other applications.
The way I see it, the marriage of China’s position as the world’s supplier of hemp -- and its burgeoning semiconductor industry -- could be the key to China’s hegemony over the microchip industry. Semiconductors are traditionally made using silicon. Graphene semiconductors, however, could one day lead to computers that are a thousand times faster, consume significantly less power and are smaller than silicon semiconductors used in computer transistors. In application, graphene’s dwindling supply and costly manufacturing issues would still exist. Putting this all together, Mitlin’s research has sparked interest in the potential for hemp to create the next-generation semiconductor.
Karl W. Hillig, a graduate student in the laboratory of long-time Cannabis researcher Paul G. Mahlberg[77] at Indiana University, conducted a systematic investigation of genetic, morphological, and chemotaxonomic variation among 157 Cannabis accessions of known geographic origin, including fiber, drug, and feral populations. In 2004, Hillig and Mahlberg published a chemotaxonomic analysis of cannabinoid variation in their Cannabis germplasm collection. They used gas chromatography to determine cannabinoid content and to infer allele frequencies of the gene that controls CBD and THC production within the studied populations, and concluded that the patterns of cannabinoid variation support recognition of C. sativa and C. indica as separate species, but not C. ruderalis.[52] The authors assigned fiber/seed landraces and feral populations from Europe, Central Asia, and Turkey to C. sativa. Narrow-leaflet and wide-leaflet drug accessions, southern and eastern Asian hemp accessions, and feral Himalayan populations were assigned to C. indica. In 2005, Hillig published a genetic analysis of the same set of accessions (this paper was the first in the series, but was delayed in publication), and proposed a three-species classification, recognizing C. sativa, C. indica, and (tentatively) C. ruderalis.[55] In his doctoral dissertation published the same year, Hillig stated that principal components analysis of phenotypic (morphological) traits failed to differentiate the putative species, but that canonical variates analysis resulted in a high degree of discrimination of the putative species and infraspecific taxa.[78] Another paper in the series on chemotaxonomic variation in the terpenoid content of the essential oil of Cannabis revealed that several wide-leaflet drug strains in the collection had relatively high levels of certain sesquiterpene alcohols, including guaiol and isomers of eudesmol, that set them apart from the other putative taxa.[79] Hillig concluded that the patterns of genetic, morphological, and chemotaxonomic variation support recognition of C. sativa and C. indica as separate species. He also concluded there is little support to treat C. ruderalis as a separate species from C. sativa at this time, but more research on wild and weedy populations is needed because they were underrepresented in their collection.

The arrival of Epidiolex is unlikely to erase the unregulated CBD market, however. For one, Epidiolex has been studied only in connection with a small number of epileptic conditions. If and when Epidiolex makes its way to drug stores, it will be approved only for the treatment of Dravet Syndrome and Lennox-Gastaut Syndrome, two rare forms of catastrophic epilepsy. People like me, with comparatively mild Janz Syndrome, and people like Harper, with extremely rare conditions like CDKL5, may still be out of luck.
States have passed laws creating or allowing for the establishment of industrial hemp research or pilot programs. State agencies and institutions of higher education administer these programs in order to study the cultivation, processing, and economics of industrial hemp. Pilot programs may be limited to a certain period of time and may require periodic reporting from participants and state agencies. Some states establish specific regulatory agencies or committees, rules, and goals to oversee the research programs. States may also require coordination between specific colleges or universities and the programs, in other states coordination is optional. From 2015 to 2016, seven states enacted legislation to create hemp research or pilot programs, including Pennsylvania (H.B. 976) and Hawaii (S.B. 2659).
Hemp has the ability to mitigate the toxin transfer from contaminated soil into food products. This process uses phytoremediation, an organic process where toxins are absorbed by plant roots and then stored in the cellulose for disposal. Hemp phytoremediation became more well-known after the Chernobyl disaster for its use in helping grow crops that are safe for consumption.
Preliminary research indicates that cannabidiol may reduce adverse effects of THC, particularly those causing intoxication and sedation, but only at high doses.[26] Safety studies of cannabidiol showed it is well-tolerated, but may cause tiredness, diarrhea, or changes in appetite as common adverse effects.[27] Epidiolex documentation lists sleepiness, insomnia and poor quality sleep, decreased appetite, diarrhea, and fatigue.[3]
The Spaniards brought hemp to the Americas and cultivated it in Chile starting about 1545.[110] Similar attempts were made in Peru, Colombia, and Mexico, but only in Chile did the crop find success.[111] In July 1605, Samuel Champlain reported the use of grass and hemp clothing by the (Wampanoag) people of Cape Cod and the (Nauset) people of Plymouth Bay told him they harvested hemp in their region where it grew wild to a height of 4 to 5 ft. [112] In May 1607, "hempe" was among the crops Gabriel Archer observed being cultivated by the natives at the main Powhatan village, where Richmond, Virginia is now situated;[113] and in 1613, Samuell Argall reported wild hemp "better than that in England" growing along the shores of the upper Potomac. As early as 1619, the first Virginia House of Burgesses passed an Act requiring all planters in Virginia to sow "both English and Indian" hemp on their plantations.[114] The Puritans are first known to have cultivated hemp in New England in 1645.[110]
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The way I see it, the marriage of China’s position as the world’s supplier of hemp -- and its burgeoning semiconductor industry -- could be the key to China’s hegemony over the microchip industry. Semiconductors are traditionally made using silicon. Graphene semiconductors, however, could one day lead to computers that are a thousand times faster, consume significantly less power and are smaller than silicon semiconductors used in computer transistors. In application, graphene’s dwindling supply and costly manufacturing issues would still exist. Putting this all together, Mitlin’s research has sparked interest in the potential for hemp to create the next-generation semiconductor.
Marijuana is the most common illegal drug reported in motor vehicle accidents.[75] A 2012 meta-analysis found that cannabis use was associated with an increased risk of being involved in a motor vehicle crash.[76] A 2016 review also found a statistically significant increase in crash risk associated with marijuana use, but noted that this risk was "of low to medium magnitude."[77] The increase in risk of motor vehicle crash for cannabis use is between 2 and 3 times relative to baseline, whereas that for comparable doses of alcohol is between 6 and 15 times.[78]

Public heath insurance programs would be required to cover medical marijuana in New York if a new Assembly bill is enacted. “Cost is the primary barrier to patient access in New York’s medical marijuana program,” reads a memo attached to the legislation. “Medicaid, other public health plans, and commercial health insurance plans do not cover … Continue reading New York Bill Would Require Medical Marijuana Be Covered By Public Health Insurance

CBD does not appear to have any psychotropic ("high") effects such as those caused by ∆9-THC in marijuana, but may have anti-anxiety and anti-psychotic effects.[10] As the legal landscape and understanding about the differences in medical cannabinoids unfolds, it will be increasingly important to distinguish "medical marijuana" (with varying degrees of psychotropic effects and deficits in executive function) – from "medical CBD therapies” which would commonly present as having a reduced or non-psychoactive side effect profile.[10][60]

It is not surprising that male-associated markers are relatively abundant. In dioecious plants where sex chromosomes have not been identified, markers for maleness indicate either the presence of sex chromosomes which have not been distinguished by cytological methods or that the marker is tightly linked to a gene involved in sex determination.[14]

It often takes 10 to 15 years for the industry associated with a new agricultural crop to mature. While it is true that foreign imports have been the basis for hemp products in North America for at least a decade, North American production is only 4 years of age in Canada, and farming of hemp in the US has not even begun. Viewed from this perspective, the hemp industry in North America is still very much in its infancy. Varieties of hemp specifically suited to given products and regions have only started to be developed in North America. There is considerable uncertainty regarding yields, costs of production, harvesting and processing equipment, product characteristics, foreign competition, governmental support, and the vagaries of the regulatory environment. Hemp is not presently a standard crop, and is likely to continue experiencing the risks inherent in a small niche market for some time. Hemp is currently a most uncertain crop, but has such a diversity of possible uses, is being promoted by extremely enthusiastic market developers, and attracts so much attention that it is likely to carve out a much larger share of the North American marketplace than its detractors are willing to concede.

Henry Ford recognized the utility of hemp in early times. In advance of today’s automobile manufacturers, he constructed a car with certain components made of resin stiffened with hemp fiber (Fig. 19). Rather ironically in view of today’s parallel situation, Henry Ford’s hemp innovations in the 1920s occurred at a time of crisis for American farms, later to intensify with the depression. The need to produce new industrial markets for farm products led to a broad movement for scientific research in agriculture that came to be labeled “Farm Chemurgy,” that today is embodied in chemical applications of crop constituents.

Dr. Ethan Russo, medical director at Phytecs, a biotechnology company spearheading research into plant- based medicines and the endocannabinoid system, took issue with Titus’s claim, however. “Bioaccumulators can recruit heavy metals from the soil,” Russo said, “but breaking them down would be alchemy.” Government regulation of the pharmaceutical industry is designed to protect consumers from unfounded scientific claims.

Recreational cannabis use centers around one chemical: the psychoactive cannabinoid tetrahydrocannabinol (THC). Consuming this chemical induces euphoric and stimulating sensations commonly referred to as a “high.” For most marijuana users, these sensations are pleasurable and enjoyable. For some, however, THC can induce feelings of anxiety and paranoia, especially in large doses.

The importation and movement of hemp seeds and plants is restricted under federal law. According to the Statement of Principles on Industrial Hemp (81 Federal Register (FR) 53395) issued by the U.S. Department of Agriculture, U.S. Drug Enforcement Administration, and U.S. Food and Drug Administration, "industrial hemp plants and seeds may not be transported across State lines." For more information, contact the U.S. Drug Enforcement Administration.
This guide is an introduction to anyone looking to inform themselves about the reality of cannabis. It covers basic information about the marijuana plant, cannabis preparations, and the crucial elements of plant anatomy and science. This guide to marijuana also gives an overview of the most popular medical and recreational uses of cannabis. It offers a survey of the most important medical cannabis research while highlighting emerging trends in the legal cannabis market. The guide also introduces those new to cannabis to the many ways to consume marijuana, and much more.
Senate Majority Leader Mitch McConnell (R-KY) is guaranteeing that the 2018 Farm Bill will include his industrial hemp legalization provision after the Senate and House reach a compromise—ideally by the end of the year. “If there’s a Farm Bill, it’ll be in there, I guarantee that,” he told reporters on Friday. McConnell said he’s visited … Continue reading Mitch McConnell Guarantees Industrial Hemp Legalization
A panellized system of hemp-lime panels for use in building construction is currently under test in a European Union-funded research collaboration led by the University of Bath. The panels are being designed to assure high-quality construction, rapid on-site erection, optimal hygrothermal performance from day one, and energy- and resource-efficient buildings. The 36-month-long work programme aims to refine product and manufacturing protocols, produce data for certification and marketing, warranty, insurance cover, and availability of finance. It also includes the development of markets in Britain, France, and Spain.[32]
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