Cannabis is believed to be an aggravating factor in rare cases of arteritis, a serious condition that in some cases leads to amputation. Because 97% of case-reports also smoked tobacco, a formal association with cannabis could not be made. If cannabis arteritis turns out to be a distinct clinical entity, it might be the consequence of vasoconstrictor activity observed from delta-8-THC and delta-9-THC. Other serious cardiovascular events including myocardial infarction, stroke, sudden cardiac death, and cardiomyopathy have been reported to be temporally associated with cannabis use. Research in these events is complicated because cannabis is often used in conjunction with tobacco, and drugs such as alcohol and cocaine. These putative effects can be taken in context of a wide range of cardiovascular phenomena regulated by the endocannabinoid system and an overall role of cannabis in causing decreased peripheral resistance and increased cardiac output, which potentially could pose a threat to those with cardiovascular disease. There is some evidence from case reports that cannabis use may provoke fatal cardiovascular events in young people who have not been diagnosed with cardiovascular disease. Smoking cannabis has also been shown to increase the risk of myocardial infarction by 4.8 times for the 60 minutes after consumption.
Medical marijuana in the U.S. is controlled at the state level. Per federal law, cannabis is illegal as noted in the Controlled Substances Act, but the federal government has stated they will not actively prosecute patients and caregivers complying with state medical marijuana laws. However, use of medical marijuana outside of the state laws for illegal use or trafficking will not be tolerated by state or federal government.
In Europe and Asia, hemp farming has been conducted for millennia. Although most countries ceased growing hemp after the second word war, some didn’t, including France, China, Russia, and Hungary, so that essential knowledge of how to grow and process hemp was maintained. When commercial hemp cultivation resumed in Canada in 1997, many farmers undertook to grow the crop without appreciating its suitability for their situation, or for the hazards of an undeveloped market. Hemp was often grown on farms with marginal incomes in the hopes that it was a savior from a downward financial spiral. The myth that hemp is a wonder crop that can be grown on any soil led some to cultivate on soils with a history of producing poor crops; of course, a poor crop was the result.
The first step to finding your correct CBD dosage is getting as much information as you can about the product you’re using. What is the concentration of CBD? Are there third-party lab tests that can confirm that? The CBD industry is still mainly a grassroots therapeutic movement, and as such, largely unregulated. Concentration and purity levels can differ greatly depending on the manufacturing process.
According to DSM-V criteria, 9% of those who are exposed to cannabis develop cannabis use disorder, compared to 20% for cocaine, 23% for alcohol and 68% for nicotine. Cannabis abuse disorder in the DSM-V involves a combination of DSM-IV criteria for cannabis abuse and dependence, plus the addition of craving, minus the criterion related to legal troubles.
Hemp seeds have an attractive nutty taste, and are now incorporated into many food preparations (Fig. 34), often mimicking familiar foods. Those sold in North America include nutritional (granola-type) or snack bars, “nut butters” and other spreads, bread, pretzels, cookies, yogurts, pancakes, porridge, fruit crumble, frozen dessert (“ice cream”), pasta, burgers, pizza, salt substitute, salad dressings, mayonnaise, “cheese,” and beverages (“milk,” “lemonade,” “beer,” “wine,” “coffee nog”). Hemp seed is often found canned or vacuum-packed (Fig. 35). Alcoholic beverages made with hemp utilize hempseed as a flavorant. Hemp food products currently have a niche market, based particularly on natural food and specialty food outlets.
And now, onto the thorny issue of legality. The simple answer to the question is yes – if it is extracted from hemp. The 2014 Farm Bill established guidelines for growing hemp in the U.S. legally. This so-called “industrial hemp” refers to both hemp and hemp products which come from cannabis plants with less than 0.3 percent THC and are grown by a state-licensed farmer.
Jump up ^ Fusar-Poli, Paolo; Crippa, José A.; Bhattacharyya, Sagnik; Borgwardt, Stefan J.; Allen, Paul; Martin-Santos, Rocio; Seal, Marc; Surguladze, Simon A.; O'Carrol, Colin; Atakan, Zerrin; Zuardi, Antonio W.; McGuire, Philip K. (2009). "Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing". Archives of General Psychiatry. 66 (1): 95–105. doi:10.1001/archgenpsychiatry.2008.519. PMID 19124693.
A 2012 review found that the THC content in marijuana had increased worldwide from 1970 to 2009. It is unclear, however, whether the increase in THC content has caused people to consume more THC or if users adjust based on the potency of the cannabis. It is likely that the higher THC content allows people to ingest less tar. At the same time, CBD levels in seized samples have lowered, in part because of the desire to produce higher THC levels and because more illegal growers cultivate indoors using artificial lights. This helps avoid detection but reduces the CBD production of the plant.
Hemp hasn't always been on the wrong side of the authorities. The Puritans brought hemp with them to New England in 1645 and Europeans were growing it even earlier in Chile. George Washington planted hemp as one of several crops at his Mount Vernon estate. However, hemp's popularity waned in America as other plants used for textiles such as cotton and jute became more widely available. The U.S. Navy briefly campaigned for more hemp farming during World War II to supply ropes for ships. But the federal government continued restrictions on hemp after the war.
If you decide to cut back or stop after using cannabis regularly, you may experience psychological and physical withdrawal symptoms such as irritability, sleep difficulty, vivid dreams, and decreased appetite. Talk to a trusted friend or family member about your plan to change, and ask them to look out for and support you. Alternatively, call Alcohol and Drug Helpline 0800 787 797 for confidential, non-judgmental advice and referral to a local service provider.
While researchers are calling for more robust studies on the role of CBD on mood disorders, there is promising research that points to CBD’s role as an anxiolytic – which means it has anti-anxiety effects. Another study showed CBD to have antidepressant effects comparable to those of the prescription antidepressant Imipramine. We noted above that CBD increases levels of glutamate and serotonin – and it’s these same neurotransmitters that play a crucial role in mood regulation.
Cannabis is used in three main forms: marijuana, hashish and hash oil. Marijuana is made from dried flowers and leaves of the cannabis plant. It is the least potent of all the cannabis products and is usually smoked or made into edible products like cookies or brownies (see Factsheet: Marijuana Edibles). Hashish is made from the resin (a secreted gum) of the cannabis plant. It is dried and pressed into small blocks and smoked. It can also be added to food and eaten. Hash oil, the most potent cannabis product, is a thick oil obtained from hashish. It is also smoked.
Hemp seeds contain virtually no THC, but THC contamination results from contact of the seeds with the resin secreted by the epidermal glands on the leaves and floral parts, and also by the failure to sift away all of the bracts (which have the highest concentration of THC of any parts of the plant) that cover the seeds. This results in small levels of THC appearing in hempseed oil and foods made with the seeds. Although most of the western hemp-growing world uses 0.3% THC as a maximum concentration for authorized cultivation of hemp plants, regulations in various countries allow only a much lower level of THC in human food products manufactured from the seeds. Currently, up to 10 ppm THC is permitted in seeds and oil products used for food purposes in Canada. In Germany, more stringent limits were set for food in 2000: 5 ppm in food oil, 0.005 ppm in beverages, and 0.15 ppm in all other foods. The US Drug Enforcement Administration published new regulations on hemp in the Federal Register on October 9th 2001 that in effect 4 months later would ban the food use of hemp in the US because any amount of THC would be unacceptable in foods (follow links at www.hempreport.com/). These proposals are currently being challenged by the hemp industry. Limits have been set because of concerns about possible toxicity and interference with drug tests (Grotenhermen et al. 1998). An extensive analysis of literature dealing with the toxicity of hemp is in Orr and Starodub (1999; see Geiwitz 2001 for an analysis). Because hemp food products are considered to have great economic potential, there is considerable pressure on the hemp industry in North America to reduce THC levels.
You then take your first drop of CBD oil, wait 45 minutes, then ask the questions again. If you feel no different and there’s no change in the way you answer those questions, you increase the dose by small increments until you do notice a difference. You can continue this process over several days – and at some point, you’ll find that taking more doesn’t change your scores. That is your minimum effective dose.
Sec. 7606. Legitimacy of Industrial Hemp Research contained in the 2014 Federal Farm Bill, which was signed into law Feb. 7, provides for the cultivation of industrial hemp for purposes of research by institutions of higher education or state departments of agriculture in states where it is legal. The interaction of the U.S. Drug Enforcement Agency (DEA) and the provisions of Sec. 7606 is a developing process. As TDA develops Tennessee's industrial hemp program every effort will be made to minimize the impact of federal law on potential hemp producers in Tennessee. In May of 2016 the law was amended to allow for a processor license.
Van Roekel (1994) has pointed out that Egyptian papyrus sheets are not “paper,” because the fiber strands are woven, not “wet-laid;” the oldest surviving paper is over 2,000 years of age, from China, and was made from hemp fiber (Fleming and Clarke 1998). Until the early 19th century, hemp, and flax were the chief paper-making materials. In historical times, hemp rag was processed into paper. Using hemp directly for paper was considered too expensive, and in any event the demand for paper was far more limited than today. Wood-based paper came into use when mechanical and chemical pulping was developed in the mid 1800s in Germany and England. Today, at least 95% of paper is made from wood pulp.
Hemp rope was used in the age of sailing ships, though the rope had to be protected by tarring, since hemp rope has a propensity for breaking from rot, as the capillary effect of the rope-woven fibers tended to hold liquid at the interior, while seeming dry from the outside. Tarring was a labor-intensive process, and earned sailors the nickname "Jack Tar". Hemp rope was phased out when Manila, which does not require tarring, became widely available. Manila is sometimes referred to as Manila hemp, but is not related to hemp; it is abacá, a species of banana.
The most valid claims to environmental friendliness of hemp are with respect to agricultural biocides (pesticides, fungicides, herbicides). Cannabis sativa is known to be exceptionally resistant to pests (Fig. 51), although, the degree of immunity to attacking organisms has been greatly exaggerated, with several insects and fungi specializing on hemp. Despite this, use of pesticides and fungicides on hemp is usually unnecessary, although introduction of hemp to regions should be expected to generate local problems. Cannabis sativa is also relatively resistant to weeds, and so usually requires relatively little herbicide. Fields intended for hemp use are still frequently normally cleared of weeds using herbicides, but so long as hemp is thickly seeded (as is always done when hemp is grown for fiber), the rapidly developing young plants normally shade out competing weeds.
CBD has been producing a whole lot of buzz in the health community of late – but perhaps not the kind of buzz you might expect from a cannabinoid. Since you’re reading this, you’ve probably heard of CBD and its many touted benefits. From chronic pain to mental health, CBD has the potential to alleviate an astonishing number of ailments. But like many, you might be fuzzy on the details. Consider this your primer on all things CBD.
Based on reviews, smoking or vaporizing CBD vape oil seems to have less effects when compared to other methods of administering CBD, such as tinctures, capsules and sprays. On the flip side, others argue that smoking or vaporizing has less drawbacks than taking CBD orally, since ingesting CBD orally could result in inconsistent absorption and a delayed effect.
As detailed below, the development of hemp as a new legal crop in North America must be considered in relation to illicit cultivation, so it is important to appreciate the scope of the drug situation. Up until the first half of the 20th century, drug preparations of Cannabis were used predominantly as a recreational inebriant in poor countries and the lower socio-economic classes of developed nations. After World War II, marijuana became associated with the rise of a hedonistic, psychedelic ethos, first in the United States and eventually over much of the world, with the consequent development of a huge international illicit market that exceeds the value of the hemp market during its heyday. Table 3 shows the “economic significance” (dollars generated in the black market plus dollar cost of control measures) of the illicit drug industry associated with C. sativa, and contrasts this with the estimated dollar value of major categories of legitimate uses. In the Netherlands, the annual value of narcotic hemp cultivation (ca. $10 billion) exceeds the value of tulips (Collins 1999). Marijuana has become the most widely disseminated illicit species in the world (Schultes and Hofmann 1980). With the exception of alcohol, it is the most widely used recreational euphoric drug. About 25% of North Americans are believed to have used Cannabis illegally. According to the US National Institute on Drug Abuse (www.nida.nih.gov/Infofax/marijuana.html), more than 72 million Americans (33%) 12 years of age and older have tried marijuana. Cultivation, commerce, and consumption of drug preparations of Cannabis have been proscribed in most countries during the present century. The cost of enforcing the laws against Cannabis in North America is in the billions of dollars annually. In addition, there are substantial social costs, such as adverse effects on users, particularly those who are convicted. Tragically this includes some legitimate farmers who, faced with financial ruin because of the unprofitability of crops being grown, converted to growing marijuana.
Several of the cannabinoids are reputed to have medicinal potential: THC for glaucoma, spasticity from spinal injury or multiple sclerosis, pain, inflammation, insomnia, and asthma; CBD for some psychological problems. The Netherlands firm HortaPharm developed strains of Cannabis rich in particular cannabinoids. The British firm G.W. Pharmaceuticals acquired proprietary access to these for medicinal purposes, and is developing medicinal marijuana. In the US, NIH (National Institute of Health) has a program of research into medicinal marijuana, and has supplied a handful of individuals for years with maintenance samples for medical usage. The American Drug Enforcement Administration is hostile to the medicinal use of Cannabis, and for decades research on medicinal properties of Cannabis in the US has been in an extremely inhospitable climate, except for projects and researchers concerned with curbing drug abuse. Synthetic preparations of THC—dronabinol (Marinol®) and nabilone (Cesamet®)—are permitted in some cases, but are expensive and widely considered to be less effective than simply smoking preparations of marijuana. Relatively little material needs to be cultivated for medicinal purposes (Small 1971), although security considerations considerably inflate costs. The potential as a “new crop” for medicinal cannabinoid uses is therefore limited. However, the added-value potential in the form of proprietary drug derivatives and drug-delivery systems is huge. The medicinal efficacy of Cannabis is extremely controversial, and regrettably is often confounded with the issue of balancing harm and liberty concerning the proscriptions against recreational use of marijuana. This paper is principally concerned with the industrial uses of Cannabis. In this context, the chief significance of medicinal Cannabis is that, like the issue of recreational use, it has made it very difficult to rationally consider the development of industrial hemp in North America for purposes that everyone should agree are not harmful.
Another claim is that Mellon, Secretary of the Treasury and the wealthiest man in America at that time, had invested heavily in DuPont's new synthetic fiber, nylon, and believed[dubious – discuss] that the replacement of the traditional resource, hemp, was integral to the new product's success. The company DuPont and many industrial historians dispute a link between nylon and hemp, nylon became immediately a scarce commodity.[clarification needed] Nylon had characteristics that could be used for toothbrushes (sold from 1938) and very thin nylon fiber could compete with silk and rayon in various textiles normally not produced from hemp fiber, such as very thin stockings for women.
Individuals are responsible for sourcing their own propagative material. TNHIA is a great resource. All seed or plant material being brought into the state must have prior approval by the Tennessee Department of Agriculture (TDA). Please use our seed and propagule acquisition forms to request approval. If importing from another state use this link: https://www.tn.gov/content/dam/tn/agriculture/documents/planthealth/Domestic_Seed_Import_Requirements.pdf
In the EU and Canada, hemp has often been grown as a dual-purpose crop, i.e. for both fiber and oilseed. In France, dual purpose hemp is typically harvested twice—initially the upper seed-bearing part of the stems is cut and threshed with a combine, and subsequently the remaining stems are harvested. Growing hemp to the stage that mature seeds are present compromises the quality of the fiber, because of lignification. As well, the hurds become more difficult to separate. The lower quality fiber, however, is quite utilizable for pulp and non-woven usages.
CBD E-Liquid/Vape Cartridges: Vaping is excellent for people looking for an immediate response, as inhalation is the fastest way to deliver CBDs to your brain and body. To use vape simply exhale gently the air from your lungs then inhale through the mouthpiece slowly for 3 seconds. Then fill your lungs the rest of the way with additional breath and hold for a few seconds, exhaling when ready. There are pre-filled, cost-effective vape pens and cartridges available as well as more expensive vaporizers that you can refill with CBD-infused e-liquid.
These CBD-only laws also attempt to impose some regulation on CBD oils, such as establishing how much CBD and THC such products must contain. For example, on June 1, the day I sat down with Hernandez in Fort Worth, Texas, Governor Greg Abbott signed the state’s Compassionate Use Act into law in Austin. The law requires that all CBD products contain no more than 0.5 percent THC and at least 10 percent CBD. However, the bill does not specify how the state plans to enforce this requirement. The law contains no language outlining how laboratories can test CBD products, what kinds of standards they would use, or who would regulate them.
The applicant, including all corporate officers, must be fingerprinted at a law enforcement agency. The law enforcement agency, not the applicant, must send the fingerprint sheet to the Department (80-18-103, MCA). Most local law enforcement offices provide fingerprinting services. The completed application and copy of the law enforcement submitted fingerprints will be submitted for DEA review and approval. The DEA may place additional requirements on the Department or the applicant for participation or continuation of the program. At the end of the licensure, program participants must submit an agricultural/agronomic report regarding their experience with their hemp crop. The report shall include the approximate yield in pounds per acre and the method used to devitalize the seed. All seed must be devitalized after harvest and no seed production for future planting is allowed under the Montana Industrial Hemp Pilot Program.
Both in Canada and the US, the most critical problem to be addressed for commercial exploitation of C. sativa is the possible unauthorized drug use of the plant. Indeed, the reason hemp cultivation was made illegal in North America was concern that the hemp crop was a drug menace. The drug potential is, for practical purposes, measured by the presence of THC. THC is the world’s most popular illicit chemical, and indeed the fourth most popular recreational drug, after caffeine, alcohol, and nicotine. “Industrial hemp” is a phrase that has become common to designate hemp used for commercial non-intoxicant purposes. Small and Cronquist (1976) split C. sativa into two subspecies: C. sativa subsp. sativa, with less than 0.3% (dry weight) of THC in the upper (reproductive) part of the plant, and C. sativa subsp. indica (Lam.) E. Small & Cronq. with more than 0.3% THC. This classification has since been adopted in the European Community, Canada, and parts of Australia as a dividing line between cultivars that can be legally cultivated under license and forms that are considered to have too high a drug potential. For a period, 0.3% was also the allowable THC content limit for cultivation of hemp in the Soviet Union. In the US, Drug Enforcement Agency guidelines issued Dec. 7, 1999 expressly allowed products with a THC content of less than 0.3% to enter the US without a license; but subsequently permissible levels have been a source of continuing contention. Marijuana in the illicit market typically has a THC content of 5% to 10% (levels as high as 25% have been reported), and as a point of interest, a current Canadian government experimental medicinal marijuana production contract calls for the production of 6% marijuana. As noted above, a level of about 1% THC is considered the threshold for marijuana to have intoxicating potential, so the 0.3% level is conservative, and some countries (e.g. parts of Australia, Switzerland) have permitted the cultivation of cultivars with higher levels. It should be appreciated that there is considerable variation in THC content in different parts of the plant. THC content increases in the following order: achenes (excluding bracts), roots, large stems, smaller stems, older and larger leaves, younger and smaller leaves, flowers, perigonal bracts covering both the female flowers and fruits. It is well known in the illicit trade how to screen off the more potent fractions of the plant in order to increase THC levels in resultant drug products. Nevertheless, a level of 0.3% THC in the flowering parts of the plant is reflective of material that is too low in intoxicant potential to actually be used practically for illicit production of marijuana or other types of cannabis drugs. Below, the problem of permissible levels of THC in food products made from hempseed is discussed.
In May of 2018, Mount Vernon planted an industrial cultivar of hemp on the four-acre Pioneer Farm site. Under the 2015 Industrial Hemp Law enacted by the Virginia General Assembly and working with the industrial hemp research program of the University of Virginia, Mount Vernon planted hemp to expand its interpretation of George Washington’s role as an enterprising farmer. As the first historic home of the founding fathers to plant hemp, Mount Vernon will use the plant as an interpretative tool to help better tell the story of Washington’s role as a farmer.
Germplasm for the improvement of hemp is vital for the future of the industry in North America. However, there are no publicly available germplasm banks housing C. sativa in North America. The hundreds of seed collections acquired for Small’s studies (reviewed in Small 1979) were destroyed in 1980 because Canadian government policy at that time envisioned no possibility that hemp would ever be developed as a legitimate crop. An inquiry regarding the 56 United States Department of Agriculture hemp germplasm collections supplied to and grown by Small and Beckstead (1973) resulted in the reply that there are no remaining hemp collections in USDA germplasm holdings, and indeed that were such to be found they would have to be destroyed. While hemp has been and still is cultivated in Asia and South America, it is basically in Europe that germplasm banks have made efforts to preserve hemp seeds. The Vavilov Institute of Plant Research in St. Petersburg, Russia has by far the largest germplasm collection of hemp of any public gene bank, with about 500 collections. Detailed information on the majority of hemp accessions of the Vavilov Institute can be found in Anon. (1975). Budgetary problems in Russia have endangered the survival of this invaluable collection, and every effort needs to be made to find new funding to preserve it. Maintenance and seed generation issues for the Vavilov hemp germplasm collection are discussed in a number of articles in the Journal of the International Hemp Association (Clarke 1998b; Lemeshev et al. 1993, 1994). The Gatersleben gene bank of Germany, the 2nd largest public gene bank in Europe, has a much smaller Cannabis collection, with less than 40 accessions (detailed information on the hemp accessions of the Gatersleben gene bank are available at fox-serv.ipk-gatersleben.de/). Because hemp is regaining its ancient status as an important crop, a number of private germplasm collections have been assembled for the breeding of cultivars as commercial ventures (de Meijer and van Soest 1992; de Meijer 1998), and of course these are available only on a restricted basis, if at all.
Strasser F, Luftner D, Possinger K, et al.: Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia-Study-Group. J Clin Oncol 24 (21): 3394-400, 2006. [PUBMED Abstract]
Hemp, or industrial hemp (from Old English hænep), typically found in the northern hemisphere, is a variety of the Cannabis sativa plant species that is grown specifically for the industrial uses of its derived products. It is one of the fastest growing plants and was one of the first plants to be spun into usable fiber 10,000 years ago. It can be refined into a variety of commercial items including paper, textiles, clothing, biodegradable plastics, paint, insulation, biofuel, food, and animal feed.