Newer antiemetics (e.g., 5-HT3 receptor antagonists) have not been directly compared with Cannabis or cannabinoids in cancer patients. However, the Cannabis-extract oromucosal spray, nabiximols, formulated with 1:1 THC:CBD was shown in a small pilot randomized, placebo-controlled, double-blinded clinical trial in Spain to treat chemotherapy-related N/V.[Level of evidence: 1iC] ASCO antiemetic guidelines updated in 2017 states that evidence remains insufficient to recommend medical marijuana for either the prevention or treatment of N/V in patients with cancer who receive chemotherapy or radiation therapy.
Cannabis Indica – The annual plant of the Cannabaceae family is considered a species of the genus Cannabis, but separate from Cannabis sativa, and originating in the Hindu Kush Mountains and suited for cultivation in temperate climates. Used to induce sleep, the plant is described as relatively short and conical with dense branches and short, broad leaves, while Cannabis sativa is tall with fewer branches and long, narrow leaves.
A 2015 meta analysis found that, although a longer period of abstinence was associated with smaller magnitudes of impairment, both retrospective and prospective memory were impaired in cannabis users. The authors concluded that some, but not all, of the deficits associated with cannabis use were reversible. A 2012 meta analyses found that deficits in most domains of cognition persisted beyond the acute period of intoxication, but was not evident in studies where subjects were abstinent for more than 25 days. Few high quality studies have been performed on the long-term effects of cannabis on cognition, and results were generally inconsistent. Furthermore, effect sizes of significant findings were generally small. One review concluded that, although most cognitive faculties were unimpaired by cannabis use, residual deficits occurred in executive functions. Impairments in executive functioning are most consistently found in older populations, which may reflect heavier cannabis exposure, or developmental effects associated with adolescent cannabis use. One review found three prospective cohort studies that examined the relationship between self reported cannabis use and intelligence quotient (IQ). The study following the largest number of heavy cannabis users reported that IQ declined between ages 7–13 and age 38. Poorer school performance and increased incidence of leaving school early were both associated with cannabis use, although a causal relationship was not established. Cannabis users demonstrated increased activity in task-related brain regions, consistent with reduced processing efficiency.
CBD’s potential usefulness in treating certain conditions is yet another argument in favor of legalizing the entire cannabis plant. Removing cannabis from the federal list of Schedule I narcotics that are illegal under the Controlled Substances Act would allow scientists to research its full medical potential and pharmaceutical companies in the United States to develop marijuana-based drugs and submit them for FDA approval. Government-regulated labs could test products like CBD oil to ensure safety and quality. Doctors could prescribe marijuana- based medicines with full knowledge of potential side effects and drug interactions, and without fear of losing their medical licenses or being thrown in jail.
The Cannabis plant has a history of medicinal use dating back thousands of years across many cultures. The Yanghai Tombs, a vast ancient cemetery (54 000 m2) situated in the Turfan district of the Xinjiang Uyghur Autonomous Region in northwest China, have revealed the 2700-year-old grave of a shaman. He is thought to have belonged to the Jushi culture recorded in the area centuries later in the Hanshu, Chap 96B. Near the head and foot of the shaman was a large leather basket and wooden bowl filled with 789g of cannabis, superbly preserved by climatic and burial conditions. An international team demonstrated that this material contained tetrahydrocannabinol, the psychoactive component of cannabis. The cannabis was presumably employed by this culture as a medicinal or psychoactive agent, or an aid to divination. This is the oldest documentation of cannabis as a pharmacologically active agent.
Another field in which CBD is creating a buzz is in the area of mood disorders like anxiety and depression. Both conditions have been treated with a variety of medications, courtesy of Big Pharma, that have had varying levels of success. Again, the long list of side effects can be off-putting to someone who just wants to get through the day without the sweaty tension of anxiety or the gray haze of depression.
CBD vaporizer oils can be used in a vaporizer of your choice. They offer a healthy way of inhaling your daily dose of the CBD supplement. Vaping is a very direct way of ingesting CBD oil. When you vape, the CBD enters the lungs and goes directly into the bloodstream, completely bypassing the digestive system. This method allows for greater bioavailability.
In 2013, BMW announced its newest electric car, the i3. Using low-weight hemp in its interior, the i3 weighs 800 pounds less than its market competitors. The Kestrel, created by Canadian Motive Industries, uses polymer resin-infused hemp stalks to replace fiberglass in the body of the vehicle. From this replacement, consumers can expect a dramatic reduction in weight, improved efficiency and the appeal of an ecologically sustainable vehicle.
Another study examined the effects of a plant extract with controlled cannabinoid content in an oromucosal spray. In a multicenter, double-blind, placebo-controlled study, the THC:CBD nabiximols extract and THC extract alone were compared in the analgesic management of patients with advanced cancer and with moderate-to-severe cancer-related pain. Patients were assigned to one of three treatment groups: THC:CBD extract, THC extract, or placebo. The researchers concluded that the THC:CBD extract was efficacious for pain relief in advanced cancer patients whose pain was not fully relieved by strong opioids. In a randomized, placebo-controlled, graded-dose trial, opioid-treated cancer patients with poorly controlled chronic pain demonstrated significantly better control of pain and sleep disruption with THC:CBD oromucosal spray at lower doses (1–4 and 6–10 sprays/day), compared with placebo. Adverse events were dose related, with only the high-dose group (11–16 sprays/day) comparing unfavorably with the placebo arm. These studies provide promising evidence of an adjuvant analgesic effect of THC:CBD in this opioid-refractory patient population and may provide an opportunity to address this significant clinical challenge. An open-label extension study of 43 patients who had participated in the randomized trial found that some patients continued to obtain relief of their cancer-related pain with long-term use of the THC:CBD oromucosal spray without increasing their dose of the spray or the dose of their other analgesics.
Medical reviews published in 2017 and 2018 incorporating numerous clinical trials concluded that cannabidiol is an effective treatment for certain types of childhood epilepsy. An orally administered cannabidiol solution (brand name Epidiolex) was approved by the US Food and Drug Administration in June 2018 as a treatment for two rare forms of childhood epilepsy, Lennox-Gastaut syndrome and Dravet syndrome.
Hi, I had ovarian cancer stage 2 and went to do chemotherapy for 16 times in 2014. It came back last year 2016 but I did not do chemotherapy or radiation therapy as suggested by the doctor. I am taking hormone therapy at the moment. I would like to use cannabis oil but which one and how much CBD and how much THC should I take for ovarian cancer? Can anyone give some idea?. Thank you very much.
Via CB1 receptor activation, THC indirectly increases dopamine release and produces psychotropic effects. Cannabidiol (CBD) also acts as an allosteric modulator of the μ- and δ-opioid receptors. THC also potentiates the effects of the glycine receptors. It is unknown if or how these actions contribute to the effects of cannabis.
Cannabis plants can be male, female, or hermaphrodite. The dried marijuana flowers that humans consume, however, come from the female plant. That’s because female plants produce large resin-secreting flowers that are rich in cannabinoids and free of seeds. Hence, female plants are the ones growers prefer, though of course, male marijuana plants are a requirement for pollination.
Traditionally, hemp fiber has been a very coarse fiber when raw, which made it well suited to rope but less than ideal for clothing designed to be worn against delicate human skin. Advances in breeding of the plants and treatment/processing of the fibers have resulted in a much finer, softer hemp fiber, which is ideal for weaving into hemp clothing, fabrics and rope. Watch the video on Hemp for victory to learn more about the importance of hemp during war times.
Governor Jeff Colyer, M.D. signed Senate Bill 263 on April 20, which enacts the Alternative Crop Research Act allowing the Kansas Department of Agriculture to oversee the cultivation of industrial hemp in a research program. KDA has begun the process of developing rules and regulations to guide the Alternative Crop Research Act, which included an open dialogue and information exchange at a public forum May 11. Content from that forum is included on this page.
What is cannabis?Cannabis is a drug that comes from Indian hemp plants such as Cannabis sativa and Cannabis indica. The main active chemical in cannabis is THC (delta-9 tetrahydrocannabinol).Cannabis is a depressant drug. Depressant drugs do not necessarily make you feel depressed. Rather, they slow down the activity of the central nervous system and the messages going between the brain and the body. When large doses of cannabis are taken it may also produce hallucinogenic effects.For information on synthetic cannabinoids, see our "Legal high" facts page.Other namesCannabis is also known as grass, pot, hash, weed, reefer, dope, herb, mull, buddha, ganja, joint, stick, buckets, cones, skunk, hydro, yarndi, smoke and hooch.What does cannabis look like?Leaves from the cannabis plant are bright green and have a distinctive shape with five or seven leaflets. The flowering tops and upper leaves are covered in a sticky resin.Cannabis is used for the psychoactive (mind and mood-altering) effects of THC and other active ingredients. THC is the chemical in cannabis that makes you feel “high”.There are three main forms of psychoactive cannabis: marijuana, hashish and hash oil.Marijuana is the most common and least potent form of cannabis. Marijuana is the dried leaves and flowers of the plant.Hashish (“hash”) is dried cannabis resin, usually in the form of a small block. The concentration of THC in hashish is higher than in marijuana, producing stronger effects.Hash oil is a thick, oily liquid, golden brown to black in colour, which is extracted from cannabis. Hash oil is the strongest form of cannabis.How and why is it used?The different forms of cannabis are used in different ways:Marijuana is smoked in hand-rolled cigarettes (joints), or in a pipe (a bong).Hashish is usually added to tobacco and smoked, or baked and eaten in foods such as hash cookies.Hash oil is usually spread on the tip or paper of a cigarette and then smoked.Cannabis and hash can also be smoked in a vaporiser. Vaporisers heat cannabis to temperatures that release its active ingredients while minimising the toxins associated with burning.The THC in cannabis is absorbed into the bloodstream through the walls of the lungs (if smoked), or through the walls of the stomach and intestines (if eaten). The bloodstream carries the THC to the brain, producing the “high” effects. Drugs inhaled get into the bloodstream quicker than those eaten. This means that the effects of cannabis when smoked occur more rapidly than when eaten.Paper and textilesSome species of cannabis have few psychoactive effects. These plants are used to produce hemp fibre for use in paper, textiles and clothing.Medical usesCannabis has been used for medical purposes for many centuries. It has been reported that cannabis may be useful to help conditions such as:nausea and vomiting, particularly when associated with chemotherapywasting and severe weight loss, in people with HIV/AIDS, cancer, or anorexia nervosa, as it may be used as an appetite stimulantpain relief, for example in people with cancer and arthritisrelief from symptoms of some neurological disorders that involve muscle spasms, including multiple sclerosis and spinal cord injuryglaucomaepilepsyasthma.For more information, please click on the Australian Drug Foundation's DrugInfo Clearinghouse web site link below.
The question of whether heteromorphic sex chromosomes are indeed present is most conveniently answered if such chromosomes were clearly visible in a karyotype. Cannabis was one of the first plant species to be karyotyped; however, this was in a period when karyotype preparation was primitive by modern standards (see History of Cytogenetics). Heteromorphic sex chromosomes were reported to occur in staminate individuals of dioecious "Kentucky" hemp, but were not found in pistillate individuals of the same variety. Dioecious "Kentucky" hemp was assumed to use an XY mechanism. Heterosomes were not observed in analyzed individuals of monoecious "Kentucky" hemp, nor in an unidentified German cultivar. These varieties were assumed to have sex chromosome composition XX. According to other researchers, no modern karyotype of Cannabis had been published as of 1996. Proponents of the XY system state that Y chromosome is slightly larger than the X, but difficult to differentiate cytologically.
As of November 2016, 28 states and the District of Columbia legally allow cannabis for personal medical use. Rules surrounding the use of medical cannabis (medical marijuana) vary by state. The first state in the union to legalize the medical use of marijuana was California in 1996. States that allow medical marijuana include: Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Hawaii, Illinois, Maine, Maryland, Massachusetts, Michigan, Minnesota, Montana, Nevada, New Hampshire, New Jersey, New Mexico, North Dakota, New York, Ohio, Oregon, Pennsylvania, Rhode Island, Vermont, Washington, and the District of Columbia. It is important to recognize that these state marijuana laws do not change the fact that using marijuana continues to be an offense under Federal law.
Canabidol™ CBD cannabis oil (CBD Oli) is derived from EU approved, UK & US legal, industrial hemp (Cannabis Sativa L.) The active ingredient is Cannabidiol as our products are THC free, meaning that they are non psychoactive so will not get you high. CBD Oil (Cannabidiol) is not scheduled and is found in all hemp products which makes it legal in both the UK and US. Manufactured in England to the highest standards Canabidol™ is now sent out from our United Kingdom distribution centre. You can also purchase our range of CBD oil products direct from one of our many stores across the UK.
In 2012, voters in Colorado and Washington state passed initiatives legalizing cannabis for adults 21 and older under state law. In November 2014, Oregon, Alaska, and Washington D.C also approved recreational use of marijuana. In November 2016, four more states - California, Massachusetts, Maine, and Nevada - voted in recreational marijuana. It is important to note that the federal government still considers cannabis a dangerous drug and that the illegal distribution and sale of marijuana is a serious crime. Under the Controlled Substances Act (CSA), marijuana is still considered a Schedule 1 drug. Cultivation and distribution of marijuana are felonies; possession for personal use is a misdemeanor; possession of “paraphernalia” is also illegal. Cultivating 100 plants or more carries a mandatory minimum sentence of five years according to federal statutes.
Cannabis use generally makes psychotic symptoms worse and lowers the person’s chances of recovery from a psychotic episode. People with a psychotic illness who use drugs experience more delusions, hallucinations and other symptoms. They have a higher rate of hospitalisation for psychosis, and treatment is generally less effective for them. People with a psychotic illness should not use cannabis.
Until 2017, products containing cannabidiol that are marketed for medical purposes were classed as medicines by the UK regulatory body, the Medicines and Healthcare products Regulatory Agency (MHRA) and could not be marketed without regulatory approval for the medical claims. CBD oil with THC content not exceeding 0.2% was legalized throughout the UK in 2017. Cannabis oil, however, remained illegal to possess, buy and sell.
CBD concentrates typically contain the strongest dosage of CBD compared to any other CBD products. It can contain up to 10 times the average CBD products. Concentrates are also convenient in that it only takes a few seconds to consume. Overall, CBD concentrates seem to be most popular among customers who are extremely busy, yet seek high potency CBD.
It is clear that there is a culture of idealistic believers in hemp in North America, and that there is great determination to establish the industry. As history has demonstrated, unbridled enthusiasm for largely untested new crops touted as gold mines sometimes leads to disaster. The attempt to raise silk in the US is probably the most egregious example. In 1826 a Congressional report that recommended the preparation of a practical manual on the industry resulted in a contagious desire to plant mulberries for silk production, with the eventual collapse of the industry, the loss of fortunes, and a legacy of “Mulberry Streets” in the US (Chapter 2, Bailey 1898). In the early 1980s in Minnesota, Jerusalem artichoke was touted as a fuel, a feed, a food, and a sugar crop. Unfortunately there was no market for the new “wonder crop” and hundreds of farmers lost about $20 million (Paarlberg 1990). The level of “hype” associated with industrial hemp is far more than has been observed before for other new crops (Pinfold Consulting 1998). Probably more so than any plant in living memory, hemp attracts people to attempt its cultivation without first acquiring a realistic appreciation of the possible pitfalls. American presidents George Washington and Thomas Jefferson encouraged the cultivation of hemp, but both lost money trying to grow it. Sadly in Canada in 1999 numerous farmers contracted to grow half of Canada’s crop area for hemp for the American-based Consolidated Growers and Processors, and with the collapse of the firm were left holding very large amounts of unmarketable grain and baled hemp straw. This has represented a most untimely setback for a fledgling industry, but at least has had a sobering effect on investing in hemp. In this section we emphasize why producers should exercise caution before getting into hemp.
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I have digenerative disc disease/4 bulgin discs was taking 9---10mg hydrocodones a day... i started with 3 drops of 300mg and within 5 mins started feeling better than i have theses last 6 years or so... not only that, the inflamation has decrease substantially, i wake up with energy and have begun to work out again... if im making it seem like a miracle drug... its because it is... so the first week i took 3 drops twice a day... now 3 weeks in... im taking about 5 drops 3 times a day and zero pain pills... for the first time in years i have taken control of my life agin... not depending on doctor scripts/bills etc....
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